Proteasome-dependent senescent tumor cells mediate immunosuppression through CCL20 secretion and M2 polarization in pancreatic ductal adenocarcinoma.

Humans Proteasome Endopeptidase Complex Proteasome Inhibitors / therapeutic use Carcinoma, Pancreatic Ductal / genetics Pancreatic Neoplasms / pathology Immunosuppression Therapy Chemokine CCL20 Pancreatic Neoplasms
pancreatic cancer prognosis senescence tumor microenvironment tumor-associated macrophages

Journal

Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960

Informations de publication

Date de publication:
2023
Historique:
received: 03 05 2023
accepted: 05 06 2023
medline: 5 7 2023
pubmed: 3 7 2023
entrez: 3 7 2023
Statut: epublish

Résumé

The outcome of pancreatic ductal adenocarcinoma (PDAC) remains poor due to few therapeutic options available and challenges with precision therapy to target each tumour's specific characteristics. In this study, a biologically meaningful patient stratification-prognostic model with therapeutic suggestion value based on tumor senescence was developed and validated in multiple independent cohorts. Further mechanistic investigation based on single-cell transcriptomic data and

Identifiants

DOI: 10.3389/fimmu.2023.1216376 PMID: 37398643 PMC: PMC10310997
pubmed: 37398643
doi: 10.3389/fimmu.2023.1216376
pmc: PMC10310997
doi:

Substances chimiques

Proteasome Endopeptidase Complex EC 3.4.25.1
Proteasome Inhibitors 0
CCL20 protein, human 0
Chemokine CCL20 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1216376

Informations de copyright

Copyright © 2023 Wu, Han, Wu and Liu.

Déclaration de conflit d'intérêts

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Références

Front Cell Dev Biol. 2021 Nov 05;9:743908
pubmed: 34805152
Innovation (Camb). 2021 Jul 01;2(3):100141
pubmed: 34557778
Nat Genet. 2020 Feb;52(2):231-240
pubmed: 31932696
Drug Resist Updat. 2012 Feb-Apr;15(1-2):123-31
pubmed: 22365330
Aging Cell. 2016 Dec;15(6):999-1017
pubmed: 27628712
Nat Med. 2011 Apr;17(4):500-3
pubmed: 21460848
BMC Bioinformatics. 2008 Dec 29;9:559
pubmed: 19114008
JAMA Oncol. 2018 Feb 01;4(2):203-209
pubmed: 29222540
World J Gastroenterol. 2016 Nov 28;22(44):9694-9705
pubmed: 27956793
Genome Biol. 2020 Apr 7;21(1):91
pubmed: 32264951
BMB Rep. 2014 Feb;47(2):51-9
pubmed: 24411464
Gerontology. 2019;65(5):505-512
pubmed: 31212284
Nat Rev Gastroenterol Hepatol. 2019 Apr;16(4):207-220
pubmed: 30718832
Trends Cell Biol. 2018 Jun;28(6):436-453
pubmed: 29477613
Semin Cancer Biol. 2022 Nov;86(Pt 3):827-845
pubmed: 35143990
Cell Death Discov. 2022 Jan 10;8(1):13
pubmed: 35013121
Genome Res. 2018 Nov;28(11):1747-1756
pubmed: 30341162
Nat Rev Clin Oncol. 2022 Oct;19(10):619-636
pubmed: 36045302
Int J Mol Sci. 2021 Dec 27;23(1):
pubmed: 35008679
Genome Biol. 2014;15(12):550
pubmed: 25516281
Gastroenterology. 2018 Dec;155(6):1999-2013.e3
pubmed: 30165049
Signal Transduct Target Ther. 2023 Mar 1;8(1):97
pubmed: 36859354
Brief Bioinform. 2021 Nov 5;22(6):
pubmed: 34260682
Nature. 2015 Feb 26;518(7540):495-501
pubmed: 25719666
Nucleic Acids Res. 2015 Apr 20;43(7):e47
pubmed: 25605792
Cell. 2021 Jun 24;184(13):3573-3587.e29
pubmed: 34062119
BMC Bioinformatics. 2010 Jul 02;11:367
pubmed: 20598126
Int J Mol Sci. 2021 Dec 06;22(23):
pubmed: 34884978
Lancet. 2020 Jun 27;395(10242):2008-2020
pubmed: 32593337
Nat Methods. 2017 Nov;14(11):1083-1086
pubmed: 28991892
Cell Death Dis. 2016 Jan 14;7:e2053
pubmed: 26775705
Nat Commun. 2021 Feb 17;12(1):1088
pubmed: 33597522
Front Immunol. 2021 Jul 02;12:687975
pubmed: 34276676
Nat Genet. 2015 Oct;47(10):1168-78
pubmed: 26343385
Cancer Discov. 2022 Apr 1;12(4):1022-1045
pubmed: 34911733
Bioinformatics. 2016 Sep 15;32(18):2847-9
pubmed: 27207943
Genes Dev. 2020 Dec 1;34(23-24):1565-1576
pubmed: 33262144
Front Immunol. 2023 Feb 06;14:911368
pubmed: 36814925
Front Genet. 2022 Jun 01;13:909546
pubmed: 35719376
Nat Rev Clin Oncol. 2020 Sep;17(9):527-540
pubmed: 32398706
Cell Res. 2019 Sep;29(9):725-738
pubmed: 31273297
BMC Bioinformatics. 2013 Jan 16;14:7
pubmed: 23323831
Nucleic Acids Res. 2016 May 5;44(8):e71
pubmed: 26704973
Nat Commun. 2013;4:2612
pubmed: 24113773
Nat Rev Drug Discov. 2022 Nov;21(11):799-820
pubmed: 35974096

Auteurs

Mengwei Wu (M)

Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.

Jiashu Han (J)

Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Hao Wu (H)

Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.

Ziwen Liu (Z)

Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Proteasome-dependent senescent tumor cells...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Complexes multienzymatiques › Proteasome endopeptidase complex › Proteasome-dependent senescent tumor cells...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Mécanismes moléculaires de l'action pharmacologique › Antienzymes › Inhibiteurs de protéases › Inhibiteurs du protéasome › Proteasome-dependent senescent tumor cells...
questionsmedicales.fr › Maladies endocriniennes › Tumeurs des glandes endocrines › Tumeurs du pancréas › Carcinome du canal pancréatique › Proteasome-dependent senescent tumor cells...
questionsmedicales.fr › Maladies endocriniennes › Tumeurs des glandes endocrines › Tumeurs du pancréas › Proteasome-dependent senescent tumor cells...
questionsmedicales.fr › Techniques d'investigation › Techniques immunologiques › Immunosuppression thérapeutique › Proteasome-dependent senescent tumor cells...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Chimiokines › Protéines inflammatoires des macrophages › Chimiokine CCL20 › Proteasome-dependent senescent tumor cells...
questionsmedicales.fr › Maladies endocriniennes › Tumeurs des glandes endocrines › Tumeurs du pancréas › Proteasome-dependent senescent tumor cells...