Anti-complement 5 antibody ameliorates antibody-mediated rejection after liver transplantation in rats.

Male Rats Animals Liver Transplantation / adverse effects Complement C5 Isoantibodies Rats, Inbred Lew Kidney Transplantation Graft Rejection
antibody-mediated rejection (AMR) complement 5 donor-specific antibody (DSA) eculizumab liver transplantation

Journal

Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960

Informations de publication

Date de publication:
2023
Historique:
received: 20 03 2023
accepted: 18 05 2023
medline: 5 7 2023
pubmed: 3 7 2023
entrez: 3 7 2023
Statut: epublish

Résumé

Antibody-mediated rejection (AMR) remains a refractory rejection after donor-specific antibody (DSA)-positive or blood-type incompatible liver transplantation (LT), even in the era of pre-transplant rituximab desensitization. This is due to the lack of not only effective post-transplant treatments but also robust animal models to develop/validate new interventions. Orthotopic LT from male Dark Agouti (DA) to male Lewis (LEW) rats was used to develop a rat LT-AMR model. LEW were pre-sensitized by a preceding skin transplantation from DA 4-6 weeks before LT (

Identifiants

DOI: 10.3389/fimmu.2023.1186653 PMID: 37398677 PMC: PMC10313232
pubmed: 37398677
doi: 10.3389/fimmu.2023.1186653
pmc: PMC10313232
doi:

Substances chimiques

Complement C5 0
Isoantibodies 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1186653

Informations de copyright

Copyright © 2023 Tajima, Hata, Kusakabe, Miyauchi, Badshah, Kageyama, Zhao, Kim, Tsuruyama, Kirchner, Watanabe, Uemoto and Hatano.

Déclaration de conflit d'intérêts

S-KK is an employee of Alexion Pharmaceuticals. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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Auteurs

Tetsuya Tajima (T)

Division of Hepato-Biliary-Pancreatic Surgery and Transplantation, Department of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

Koichiro Hata (K)

Division of Hepato-Biliary-Pancreatic Surgery and Transplantation, Department of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

Jiro Kusakabe (J)

Division of Hepato-Biliary-Pancreatic Surgery and Transplantation, Department of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

Hidetaka Miyauchi (H)

Division of Hepato-Biliary-Pancreatic Surgery and Transplantation, Department of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

Joshua Sam Badshah (JS)

Department of Surgery , Division of Abdominal Transplantation, Stanford University School of Medicine, Stanford, CA, United States.

Shoichi Kageyama (S)

Division of Hepato-Biliary-Pancreatic Surgery and Transplantation, Department of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

Xiangdong Zhao (X)

Division of Hepato-Biliary-Pancreatic Surgery and Transplantation, Department of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

Sung-Kwon Kim (SK)

Alexion Pharmaceuticals Inc., New Haven, CT, United States.

Tatsuaki Tsuruyama (T)

Department of Drug Discovery Medicine, Pathology Division, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

Varvara A Kirchner (VA)

Department of Surgery , Division of Abdominal Transplantation, Stanford University School of Medicine, Stanford, CA, United States.

Takeshi Watanabe (T)

Division of Immunology, Institute for Frontier Life and Medical Sciences, Kyoto University, Kyoto, Japan.

Shinji Uemoto (S)

Division of Hepato-Biliary-Pancreatic Surgery and Transplantation, Department of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Shiga University of Medical Science, Otsu, Japan.

Etsuro Hatano (E)

Division of Hepato-Biliary-Pancreatic Surgery and Transplantation, Department of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Anti-complement 5 antibody ameliorates...
questionsmedicales.fr › Eucaryotes › Animaux › Anti-complement 5 antibody ameliorates...
questionsmedicales.fr › Procédures de chirurgie opératoire › Transplantation › Transplantation de tissu › Transplantation hépatique › Anti-complement 5 antibody ameliorates...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines du sang › Immunoprotéines › Protéines du système du complément › Complément C5 › Anti-complement 5 antibody ameliorates...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Anticorps › Alloanticorps › Anti-complement 5 antibody ameliorates...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Lignées consanguines de rats › Rats de lignée LEW › Anti-complement 5 antibody ameliorates...
questionsmedicales.fr › Procédures de chirurgie opératoire › Procédures de chirurgie urogénitale › Procédures de chirurgie urologique › Transplantation rénale › Anti-complement 5 antibody ameliorates...
questionsmedicales.fr › Phénomènes du système immunitaire › Immunologie en transplantation › Réaction de l'hôte contre le greffon › Rejet du greffon › Anti-complement 5 antibody ameliorates...