Subspace partitioning in the human prefrontal cortex resolves cognitive interference.
cognitive control
intracranial EEG
population geometry
prefrontal cortex
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
11 07 2023
11 07 2023
Historique:
pmc-release:
03
01
2024
medline:
5
7
2023
pubmed:
3
7
2023
entrez:
3
7
2023
Statut:
ppublish
Résumé
The human prefrontal cortex (PFC) constitutes the structural basis underlying flexible cognitive control, where mixed-selective neural populations encode multiple task features to guide subsequent behavior. The mechanisms by which the brain simultaneously encodes multiple task-relevant variables while minimizing interference from task-irrelevant features remain unknown. Leveraging intracranial recordings from the human PFC, we first demonstrate that competition between coexisting representations of past and present task variables incurs a behavioral switch cost. Our results reveal that this interference between past and present states in the PFC is resolved through coding partitioning into distinct low-dimensional neural states; thereby strongly attenuating behavioral switch costs. In sum, these findings uncover a fundamental coding mechanism that constitutes a central building block of flexible cognitive control.
Identifiants
pubmed: 37399398
doi: 10.1073/pnas.2220523120
pmc: PMC10334727
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2220523120Subventions
Organisme : NIMH NIH HHS
ID : P50 MH109429
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS021135
Pays : United States
Références
Nat Protoc. 2018 Jul;13(7):1699-1723
pubmed: 29988107
Proc Natl Acad Sci U S A. 2011 Jul 5;108(27):11252-5
pubmed: 21690375
Nat Neurosci. 2013 Oct;16(10):1484-91
pubmed: 23995071
Nat Commun. 2022 Oct 12;13(1):6015
pubmed: 36224207
J Neurosci. 2017 Nov 8;37(45):11037-11050
pubmed: 28972126
Trends Cogn Sci. 2003 Mar;7(3):134-140
pubmed: 12639695
PLoS Biol. 2011 Apr;9(4):e1000610
pubmed: 21532743
Elife. 2019 Aug 20;8:
pubmed: 31429827
Proc Natl Acad Sci U S A. 2016 Jun 14;113(24):6755-60
pubmed: 27247381
J Neurosci. 2023 Jan 11;43(2):282-292
pubmed: 36639905
Nat Neurosci. 2015 Sep;18(9):1318-24
pubmed: 26214371
J Neurosci. 2018 Jun 20;38(25):5759-5773
pubmed: 29798892
J Neurosci. 2020 Mar 18;40(12):2430-2444
pubmed: 32066581
Neuron. 2019 Jul 3;103(1):147-160.e8
pubmed: 31103359
J Neurosci. 2022 May 18;42(20):4131-4146
pubmed: 35422440
Proc Natl Acad Sci U S A. 2020 May 12;117(19):10603-10608
pubmed: 32341161
Neuron. 2022 Jan 5;110(1):154-174.e12
pubmed: 34678147
Neuron. 2021 Oct 6;109(19):3055-3068
pubmed: 34416170
J Neurosci. 2014 Jan 29;34(5):1970-8
pubmed: 24478376
Comput Intell Neurosci. 2011;2011:156869
pubmed: 21253357
Science. 2015 Jun 19;348(6241):1352-5
pubmed: 26089513
Science. 2022 May 6;376(6593):eabm9922
pubmed: 35511978
Trends Neurosci. 2020 Sep;43(9):725-737
pubmed: 32771224
Neuron. 2009 Dec 10;64(5):730-43
pubmed: 20005828
Cognition. 2021 Jul;212:104685
pubmed: 33780751
Trends Cogn Sci. 2016 Dec;20(12):916-930
pubmed: 27743685
Neuroimage. 1999 Feb;9(2):179-94
pubmed: 9931268
Nature. 2013 Nov 7;503(7474):78-84
pubmed: 24201281
Nat Neurosci. 2017 Dec;20(12):1770-1779
pubmed: 29184197
J Neurophysiol. 2003 Nov;90(5):3419-28
pubmed: 12867532
Hum Brain Mapp. 2004 Apr;21(4):247-56
pubmed: 15038006
Sci Adv. 2020 Aug 12;6(33):eabb0977
pubmed: 32851172
Neuron. 2014 Mar 19;81(6):1401-1416
pubmed: 24656257
Nat Hum Behav. 2018 Jan;2(1):80-91
pubmed: 29963646
J Neurophysiol. 2005 Dec;94(6):4269-80
pubmed: 16093343
Curr Biol. 2018 Sep 24;28(18):2889-2899.e3
pubmed: 30220499
Neuron. 2012 Nov 21;76(4):838-846
pubmed: 23177967
Nature. 2013 May 30;497(7451):585-90
pubmed: 23685452
Elife. 2022 Aug 15;11:
pubmed: 35968845
J Neurosci Methods. 2007 Aug 15;164(1):177-90
pubmed: 17517438
Neuron. 2007 Feb 1;53(3):453-62
pubmed: 17270740
Annu Rev Neurosci. 2001;24:167-202
pubmed: 11283309
Neuron. 2018 Aug 22;99(4):854-865.e5
pubmed: 30138591
Nat Neurosci. 2021 May;24(5):715-726
pubmed: 33821001
J Neurosci. 2017 Aug 16;37(33):7893-7905
pubmed: 28716966
Curr Opin Behav Sci. 2021 Apr;38:20-28
pubmed: 32864401
Neuron. 2017 Apr 5;94(1):183-192.e8
pubmed: 28343868
Neuron. 2015 Jun 17;86(6):1491-503
pubmed: 26087166
Science. 2006 Sep 15;313(5793):1626-8
pubmed: 16973878
Nature. 2009 May 7;459(7243):89-92
pubmed: 19270683
Sci Adv. 2019 Nov 20;5(11):eaay6279
pubmed: 31976369
Nat Commun. 2016 Oct 07;7:13098
pubmed: 27713396
Neuron. 2018 Jan 17;97(2):475
pubmed: 29346756
Curr Biol. 2021 Mar 22;31(6):1234-1244.e6
pubmed: 33639107
J Neurosci. 2013 Jan 23;33(4):1400-10
pubmed: 23345216
Curr Biol. 2009 Sep 29;19(18):1581-5
pubmed: 19747828
Nat Commun. 2017 Oct 26;8(1):1139
pubmed: 29074960
J Neurosci. 2022 Nov 23;42(47):8817-8825
pubmed: 36223998
Cereb Cortex. 2016 Aug;26(8):3508-26
pubmed: 27230218
Neuron. 2020 Feb 19;105(4):712-724.e4
pubmed: 31836322
Nat Commun. 2017 Nov 1;8(1):1242
pubmed: 29089500
Phys Rev Lett. 2004 Apr 9;92(14):148102
pubmed: 15089576