Effects of Blood Pressure on Brain Tissue Pulsation Amplitude in a Phantom Model.

Blood Pressure / physiology Brain / blood supply Intracranial Pressure / physiology Arteries Ultrasonography, Doppler, Transcranial Cerebrovascular Circulation / physiology
Brain tissue pulsation Brain tissue pulsation amplitude Brain tissue pulsations Mean arterial pressure Phantom model Pulse pressure Transcranial tissue Doppler Ultrasound

Journal

Ultrasound in medicine & biology
ISSN: 1879-291X
Titre abrégé: Ultrasound Med Biol
Pays: England
ID NLM: 0410553

Informations de publication

Date de publication:
09 2023
Historique:
received: 17 11 2022
revised: 05 06 2023
accepted: 07 06 2023
medline: 31 7 2023
pubmed: 4 7 2023
entrez: 3 7 2023
Statut: ppublish

Résumé

The precise mechanism and determinants of brain tissue pulsations (BTPs) are poorly understood, and the impact of blood pressure (BP) on BTPs is relatively unexplored. This study aimed to explore the relationship between BP parameters (mean arterial pressure [MAP] and pulse pressure [PP]) and BTP amplitude, using a transcranial tissue Doppler prototype. A phantom brain model generating arterial-induced BTPs was developed to observe BP changes in the absence of confounding variables and cerebral autoregulation feedback processes. A regression model was developed to investigate the relationship between bulk BTP amplitude and BP. The separate effects of PP and MAP were evaluated and quantified. The regression model (R Increments in BP were significantly associated with increments in bulk BTP amplitude. Further work should aim to confirm the relationship between BP and BTPs in the presence of cerebral autoregulation and explore further physiological factors having an impact on BTP measurements, such as cerebral blood flow volume, tissue distensibility and intracranial pressure.

Identifiants

DOI: 10.1016/j.ultrasmedbio.2023.06.005 PMID: 37400302
pubmed: 37400302
pii: S0301-5629(23)00200-4
doi: 10.1016/j.ultrasmedbio.2023.06.005
pii:
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

2134-2139

Informations de copyright

Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Conflict of interest The authors declare no competing interests.

Auteurs

Jennifer K Nicholls (JK)

Cerebral Haemodynamics in Ageing and Stroke Medicine (CHiASM) Research Group, Department of Cardiovascular Sciences, University of Leicester, Leicester, UK; Department of Medical Physics, University Hospitals of Leicester NHS Trust, Leicester, UK.

Poppy Turner (P)

Cerebral Haemodynamics in Ageing and Stroke Medicine (CHiASM) Research Group, Department of Cardiovascular Sciences, University of Leicester, Leicester, UK; School of Engineering, University of Leicester, Leicester, UK.

Andrea Lecchini-Visintini (A)

Cerebral Haemodynamics in Ageing and Stroke Medicine (CHiASM) Research Group, Department of Cardiovascular Sciences, University of Leicester, Leicester, UK; School of Electronics and Computer Science, University of Southampton, Southampton, UK.

Jonathan Ince (J)

Cerebral Haemodynamics in Ageing and Stroke Medicine (CHiASM) Research Group, Department of Cardiovascular Sciences, University of Leicester, Leicester, UK.

Georgina de Vries (G)

Department of Medical Physics, University Hospitals of Leicester NHS Trust, Leicester, UK.

Laurie Cappellugola (L)

Cerebral Haemodynamics in Ageing and Stroke Medicine (CHiASM) Research Group, Department of Cardiovascular Sciences, University of Leicester, Leicester, UK.

Mitsuhiro Oura (M)

Nihon Kohden Corporation, Tokorozawa-shi, Saitama, Japan.

Kelechi U Ebirim (KU)

School of Engineering, University of Leicester, Leicester, UK.

Edward Pallett (E)

Department of Medical Physics, University Hospitals of Leicester NHS Trust, Leicester, UK.

Kumar V Ramnarine (KV)

Department of Medical Physics, University Hospitals of Leicester NHS Trust, Leicester, UK; Medical Physics Department, Guy's and St Thomas' NHS Foundation Trust, London, UK.

Emma M L Chung (EML)

Cerebral Haemodynamics in Ageing and Stroke Medicine (CHiASM) Research Group, Department of Cardiovascular Sciences, University of Leicester, Leicester, UK; Department of Medical Physics, University Hospitals of Leicester NHS Trust, Leicester, UK; NIHR Leicester Biomedical Research Centre, University of Leicester, Leicester, UK; Faculty of Life Sciences and Medicine, King's College London, London, UK. Electronic address: emma.chung@kcl.ac.uk.

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Classifications MeSH

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questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Effects of Blood Pressure on Brain Tissue...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Pression du liquide cérébrospinal › Pression intracrânienne › Effects of Blood Pressure on Brain Tissue...
questionsmedicales.fr › Système cardiovasculaire › Vaisseaux sanguins › Artères › Effects of Blood Pressure on Brain Tissue...
questionsmedicales.fr › Techniques d'investigation › Neuroimagerie › Neuroradiographie › Échoencéphalographie › Échographie-doppler transcrânienne › Effects of Blood Pressure on Brain Tissue...
questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiologiques cardiovasculaires › Circulation sanguine › Circulation cérébrovasculaire › Effects of Blood Pressure on Brain Tissue...