Collagen architecture and signaling orchestrate cancer development.

Humans Neoplasms / pathology Collagen / metabolism Signal Transduction Tumor Microenvironment
DDR1 LAIR1 collagen immunity macropinocytosis tumor microenvironment

Journal

Trends in cancer
ISSN: 2405-8025
Titre abrégé: Trends Cancer
Pays: United States
ID NLM: 101665956

Informations de publication

Date de publication:
09 2023
Historique:
received: 06 04 2023
revised: 31 05 2023
accepted: 06 06 2023
medline: 18 8 2023
pubmed: 4 7 2023
entrez: 3 7 2023
Statut: ppublish

Résumé

The tumor microenvironment (TME) controls tumor progression and maintenance. Accordingly, tumor-centric cancer treatment must adjust to being more holistic and TME-centric. Collagens are the most abundant TME proteins, and their dynamic remodeling profoundly affects both TME architecture and tumor development. Recent evidence shows that in addition to being structural elements, collagens are an important source of nutrients and decisive growth controlling and immunoregulatory signals. This review focuses on macropinocytosis-dependent collagen support of cancer cell metabolism and the role of collagen fiber remodeling and trimer heterogeneity in control of tumor bioenergetics, growth, progression, and response to therapy. If properly translated, these basic advances may alter the future of cancer treatment.

Identifiants

DOI: 10.1016/j.trecan.2023.06.002 PMID: 37400314
pubmed: 37400314
pii: S2405-8033(23)00103-6
doi: 10.1016/j.trecan.2023.06.002
pii:
doi:

Substances chimiques

Collagen 9007-34-5

Types de publication

Journal Article Review Research Support, Non-U.S. Gov't Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

764-773

Subventions

Organisme : NCI NIH HHS
ID : R01 CA211794
Pays : United States
Organisme : NIAID NIH HHS
ID : R37 AI043477
Pays : United States

Informations de copyright

Copyright © 2023 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of interests None are declared by the authors.

Auteurs

Hua Su (H)

Institutes of Biomedical Sciences, Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai, China. Electronic address: suhua@fudan.edu.cn.

Michael Karin (M)

Laboratory of Gene Regulation and Signal Transduction, Departments of Pharmacology and Pathology, School of Medicine, University of California San Diego, La Jolla, CA, USA. Electronic address: karinoffice@health.ucsd.edu.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Collagen architecture and signaling...
questionsmedicales.fr › Tumeurs › Collagen architecture and signaling...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Scléroprotéines › Protéines de la matrice extracellulaire › Collagène › Collagen architecture and signaling...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Collagen architecture and signaling...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Microenvironnement cellulaire › Microenvironnement tumoral › Collagen architecture and signaling...