A medullary hub for controlling REM sleep and pontine waves.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
03 07 2023
03 07 2023
Historique:
received:
07
04
2022
accepted:
07
06
2023
medline:
5
7
2023
pubmed:
4
7
2023
entrez:
3
7
2023
Statut:
epublish
Résumé
Rapid-eye-movement (REM) sleep is a distinct behavioral state associated with vivid dreaming and memory processing. Phasic bursts of electrical activity, measurable as spike-like pontine (P)-waves, are a hallmark of REM sleep implicated in memory consolidation. However, the brainstem circuits regulating P-waves, and their interactions with circuits generating REM sleep, remain largely unknown. Here, we show that an excitatory population of dorsomedial medulla (dmM) neurons expressing corticotropin-releasing-hormone (CRH) regulates both REM sleep and P-waves in mice. Calcium imaging showed that dmM CRH neurons are selectively activated during REM sleep and recruited during P-waves, and opto- and chemogenetic experiments revealed that this population promotes REM sleep. Chemogenetic manipulation also induced prolonged changes in P-wave frequency, while brief optogenetic activation reliably triggered P-waves along with transiently accelerated theta oscillations in the electroencephalogram (EEG). Together, these findings anatomically and functionally delineate a common medullary hub for the regulation of both REM sleep and P-waves.
Identifiants
pubmed: 37400467
doi: 10.1038/s41467-023-39496-0
pii: 10.1038/s41467-023-39496-0
pmc: PMC10318054
doi:
Substances chimiques
Corticotropin-Releasing Hormone
9015-71-8
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3922Subventions
Organisme : NHLBI NIH HHS
ID : F31 HL154855
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL149133
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS110865
Pays : United States
Informations de copyright
© 2023. The Author(s).
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