Brain imaging signatures of neuropathic facial pain derived by artificial intelligence.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
03 07 2023
03 07 2023
Historique:
received:
31
10
2022
accepted:
13
06
2023
medline:
5
7
2023
pubmed:
4
7
2023
entrez:
3
7
2023
Statut:
epublish
Résumé
Advances in neuroimaging have permitted the non-invasive examination of the human brain in pain. However, a persisting challenge is in the objective differentiation of neuropathic facial pain subtypes, as diagnosis is based on patients' symptom descriptions. We use artificial intelligence (AI) models with neuroimaging data to distinguish subtypes of neuropathic facial pain and differentiate them from healthy controls. We conducted a retrospective analysis of diffusion tensor and T1-weighted imaging data using random forest and logistic regression AI models on 371 adults with trigeminal pain (265 classical trigeminal neuralgia (CTN), 106 trigeminal neuropathic pain (TNP)) and 108 healthy controls (HC). These models distinguished CTN from HC with up to 95% accuracy, and TNP from HC with up to 91% accuracy. Both classifiers identified gray and white matter-based predictive metrics (gray matter thickness, surface area, and volume; white matter diffusivity metrics) that significantly differed across groups. Classification of TNP and CTN did not show significant accuracy (51%) but highlighted two structures that differed between pain groups-the insula and orbitofrontal cortex. Our work demonstrates that AI models with brain imaging data alone can differentiate neuropathic facial pain subtypes from healthy data and identify regional structural indicates of pain.
Identifiants
pubmed: 37400574
doi: 10.1038/s41598-023-37034-y
pii: 10.1038/s41598-023-37034-y
pmc: PMC10318015
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
10699Informations de copyright
© 2023. The Author(s).
Références
PLoS One. 2021 Aug 12;16(8):e0256152
pubmed: 34383858
J Neurosurg. 2019 Jul 12;:1-9
pubmed: 31299654
Nat Methods. 2018 Apr;15(4):233-234
pubmed: 30100822
Pain. 2018 Oct;159(10):2076-2087
pubmed: 29905649
Neuroimage. 2009 Sep;47(3):987-94
pubmed: 19481610
Neuroimage. 2017 Jan;144(Pt B):262-269
pubmed: 26375206
Front Neuroanat. 2017 Sep 05;11:73
pubmed: 28928638
Hum Brain Mapp. 2018 Feb;39(2):609-621
pubmed: 29105886
Clin J Pain. 2005 Jul-Aug;21(4):311-6
pubmed: 15951648
Neuroimage. 2010 Oct 15;53(1):1-15
pubmed: 20547229
Ann Rheum Dis. 2014 Jun;73(6):968-74
pubmed: 24665116
Sci Rep. 2021 Jun 16;11(1):12688
pubmed: 34135363
Eur J Radiol. 2009 Mar;69(3):459-63
pubmed: 18035511
Nat Commun. 2020 Aug 7;11(1):3948
pubmed: 32769984
J Headache Pain. 2014 Jun 09;15:34
pubmed: 24912658
Nat Rev Mol Cell Biol. 2022 Jan;23(1):40-55
pubmed: 34518686
Radiographics. 2017 Mar-Apr;37(2):505-515
pubmed: 28212054
Nature. 2022 Mar;603(7902):654-660
pubmed: 35296861
Pain. 2014 Jan;155(1):37-44
pubmed: 23999058
Neuroimage. 2018 Oct 15;180(Pt A):68-77
pubmed: 28655633
Soc Psychol Personal Sci. 2017 May;8(4):355-362
pubmed: 28736600
Ultrasound Med Biol. 2017 Oct;43(10):2426-2437
pubmed: 28735735
Curr Opin Neurol. 2009 Aug;22(4):362-9
pubmed: 19571751
Neurosurgery. 2003 Nov;53(5):1164-6; discussion 1166-7
pubmed: 14580284
Cancers (Basel). 2021 Mar 26;13(7):
pubmed: 33810251
Neurosurgery. 2000 Jan;46(1):152-4; discussion 154-5
pubmed: 10626945
Cephalalgia. 2017 Jun;37(7):648-657
pubmed: 28076964
J Headache Pain. 2020 May 6;21(1):46
pubmed: 32375642
Neuroimage. 2013 Jul 1;74:352-8
pubmed: 23485849
PLoS One. 2010 Oct 13;5(10):e13309
pubmed: 20967200
Brain Res Bull. 2020 Sep;162:199-207
pubmed: 32603775
Database (Oxford). 2020 Jan 1;2020:
pubmed: 32185396
PLoS One. 2013 Jun 18;8(6):e66340
pubmed: 23823184
Neuroimage. 2018 Dec;183:314-326
pubmed: 30121337
Nat Med. 2022 Sep;28(9):1773-1784
pubmed: 36109635
J Craniofac Surg. 2021 Mar-Apr 01;32(2):632-636
pubmed: 33704998
Neurology. 2016 Jul 12;87(2):220-8
pubmed: 27306631
Front Neuroanat. 2016 Oct 19;10:95
pubmed: 27807409
J Neurointerv Surg. 2022 Oct;14(10):1002-1007
pubmed: 34686573
Nat Commun. 2018 Mar 16;9(1):1103
pubmed: 29549239
Neuroimage. 2006 Jul 1;31(3):968-80
pubmed: 16530430
J Neurosurg. 2018 Aug 17;131(2):539-548
pubmed: 30117773
Medicina (Kaunas). 2020 Sep 08;56(9):
pubmed: 32911665
Cereb Cortex. 2004 Jan;14(1):11-22
pubmed: 14654453
Neuroimage Clin. 2021;31:102706
pubmed: 34087549
Pain. 2015 Jun;156(6):1112-1123
pubmed: 25782366
Acupunct Med. 2006 Sep;24(3):109-17
pubmed: 17013357
Front Neuroinform. 2016 Mar 15;10:9
pubmed: 27014049
Pain. 2000 Sep;87(3):295-302
pubmed: 10963909
Mol Pharm. 2016 May 2;13(5):1445-54
pubmed: 27007977
J Neurosurg. 2002 Mar;96(3):527-31
pubmed: 11883838
Neuroimage. 2011 Mar 1;55(1):277-86
pubmed: 21156210
Can J Pain. 2020;4(1):1-18
pubmed: 32923920
Neuroimage. 2011 Feb 1;54(3):2033-44
pubmed: 20851191
Sci Data. 2021 Mar 19;8(1):85
pubmed: 33741990
J Neurosci. 2011 Apr 20;31(16):5956-64
pubmed: 21508220
J Neuroimmune Pharmacol. 2013 Jun;8(3):518-34
pubmed: 22825710
Proc Natl Acad Sci U S A. 2009 Dec 8;106(49):20900-5
pubmed: 19926861
Front Psychiatry. 2016 Mar 31;7:50
pubmed: 27064972
Soc Cogn Affect Neurosci. 2017 Apr 1;12(4):651-661
pubmed: 28119505
J Neurosurg. 2009 Dec;111(6):1231-4
pubmed: 19392593
Nat Commun. 2019 Nov 28;10(1):5416
pubmed: 31780648
Cephalalgia. 2013 Jul;33(9):629-808
pubmed: 23771276
JAMA Psychiatry. 2020 May 1;77(5):534-540
pubmed: 31774490
Lancet. 2021 May 29;397(10289):2082-2097
pubmed: 34062143