Infiltration therapy in the context of cartilage surgery.
Adipose tissue-based cell therapy
Articular cartilage
Cartilage defects
Hyaluronic acid
Platelet-rich plasma
Journal
Archives of orthopaedic and trauma surgery
ISSN: 1434-3916
Titre abrégé: Arch Orthop Trauma Surg
Pays: Germany
ID NLM: 9011043
Informations de publication
Date de publication:
04 Jul 2023
04 Jul 2023
Historique:
received:
11
11
2022
accepted:
22
06
2023
medline:
4
7
2023
pubmed:
4
7
2023
entrez:
3
7
2023
Statut:
aheadofprint
Résumé
Guideline-based surgical cartilage therapy for focal cartilage damage offers highly effective possibilities to sustainably reduce patients' complaints and to prevent or at least delay the development of early osteoarthritis. In the knee joint, it has the potential to reduce almost a quarter of the arthroses requiring joint replacement caused by cartilage damage. Biologically effective injection therapies could further improve these results. Based on the currently available literature and preclinical studies, intra- and postoperative injectables may have a positive effect of platelet-rich plasma/fibrin (PRP/PRF) and hyaluronic acid (HA) on cartilage regeneration and, in the case of HA injections, also on the clinical outcome can be assumed. The role of a combination therapy with use of intra-articular corticosteroids is lacking in the absence of adequate study data and cannot be defined yet. With regard to adipose tissue-based cell therapy, the current scientific data do not yet justify any recommendation for its use. Further studies also regarding application intervals, timing and differences in different joints are required.
Identifiants
pubmed: 37400671
doi: 10.1007/s00402-023-04964-1
pii: 10.1007/s00402-023-04964-1
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© 2023. The Author(s).
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