The mismatch negativity as an index of cognitive abilities in adults with Down syndrome.
Alzheimer’s disease (AD)
Trisomy 21
event-related potentials (ERPs)
Journal
Cerebral cortex (New York, N.Y. : 1991)
ISSN: 1460-2199
Titre abrégé: Cereb Cortex
Pays: United States
ID NLM: 9110718
Informations de publication
Date de publication:
08 08 2023
08 08 2023
Historique:
received:
03
03
2023
revised:
09
06
2023
accepted:
10
06
2023
medline:
18
8
2023
pubmed:
4
7
2023
entrez:
4
7
2023
Statut:
ppublish
Résumé
Down syndrome (DS) is associated with an ultra-high risk of developing Alzheimer's disease (AD). Understanding variability in pre-AD cognitive abilities may help understand cognitive decline in this population. The mismatch negativity (MMN) is an event-related potential component reflecting the detection of deviant stimuli that is thought to represent underlying memory processes, with reduced MMN amplitudes being associated with cognitive decline. To further understand the MMN in adults with DS without AD, we explored the relationships between MMN, age, and cognitive abilities (memory, language, and attention) in 27 individuals (aged 17-51) using a passive auditory oddball task. Statistically significant MMN was present only in 18 individuals up to 41 years of age and the latency were longer than canonical parameters reported in the literature. Reduced MMN amplitude was associated with lower memory scores, while longer MMN latencies were associated with poorer memory, verbal abilities, and attention. Therefore, the MMN may represent a valuable index of cognitive abilities in DS. In combination with previous findings, we hypothesize that while MMN response and amplitude may be associated with AD-related memory loss, MMN latency may be associated with speech signal processing. Future studies may explore the potential impact of AD on MMN in people with DS.
Identifiants
pubmed: 37401006
pii: 7217126
doi: 10.1093/cercor/bhad233
pmc: PMC10431748
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
9639-9651Subventions
Organisme : Medical Research Council
ID : MR/S011277/1
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 098330/Z/12/Z
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 209164/Z/17/Z
Pays : United Kingdom
Organisme : Medical Research Council
ID : MRCMR/S011277/1
Pays : United Kingdom
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/S005145/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/R024901/1
Pays : United Kingdom
Informations de copyright
© The Author(s) 2023. Published by Oxford University Press.
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