Effects of head-down tilt on optic nerve sheath diameter in healthy subjects.
head-down tilt
intracranial pressure
ophthalmic ultrasound
optic nerve sheath diameter
translaminar pressure
Journal
Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists)
ISSN: 1475-1313
Titre abrégé: Ophthalmic Physiol Opt
Pays: England
ID NLM: 8208839
Informations de publication
Date de publication:
Nov 2023
Nov 2023
Historique:
revised:
19
06
2023
received:
28
02
2023
accepted:
20
06
2023
pmc-release:
01
11
2024
medline:
23
10
2023
pubmed:
4
7
2023
entrez:
4
7
2023
Statut:
ppublish
Résumé
Intracranial pressure increases in head-down tilt (HDT) body posture. This study evaluated the effect of HDT on the optic nerve sheath diameter (ONSD) in normal subjects. Twenty six healthy adults (age 28 [4.7] years) participated in seated and 6° HDT visits. For each visit, subjects presented at 11:00 h for baseline seated scans and then maintained a seated or 6° HDT posture from 12:00 to 15:00 h. Three horizontal axial and three vertical axial scans were obtained at 11:00, 12:00 and 15:00 h with a 10 MHz ultrasonography probe on the same eye, randomly chosen per subject. At each time point, horizontal and vertical ONSD (mm) were quantified by averaging three measures taken 3 mm behind the globe. In the seated visit, ONSDs were similar across time (p > 0.05), with an overall mean (standard deviation) of 4.71 (0.48) horizontally and 5.08 (0.44) vertically. ONSD was larger vertically than horizontally at each time point (p < 0.001). In the HDT visit, ONSD was significantly enlarged from baseline at 12:00 and 15:00 h (p < 0.001 horizontal and p < 0.05 vertical). Mean (standard error) horizontal ONSD change from baseline was 0.37 (0.07) HDT versus 0.10 (0.05) seated at 12:00 h (p = 0.002) and 0.41 (0.09) HDT versus 0.12 (0.06) seated at 15:00 h (p = 0.002); mean vertical ONSD change was 0.14 (0.07) HDT versus -0.07 (0.04) seated at 12:00 h (p = 0.02) and 0.19 (0.06) HDT versus -0.03 (0.04) seated at 15:00 h (p = 0.01). ONSD change in HDT was similar between 12:00 and 15:00 h (p ≥ 0.30). Changes at 12:00 h correlated with those at 15:00 h for horizontal (r = 0.78, p < 0.001) and vertical ONSD (r = 0.73, p < 0.001). The ONSD increased when body posture transitioned from seated to HDT position without any further change at the end of the 3 h in HDT.
Identifiants
pubmed: 37401194
doi: 10.1111/opo.13200
pmc: PMC10592427
mid: NIHMS1915057
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1531-1539Subventions
Organisme : NEI NIH HHS
ID : P30 EY007551
Pays : United States
Organisme : NEI NIH HHS
ID : T35 EY007088
Pays : United States
Organisme : NEI NIH HHS
ID : NIH P30 EY007551
Pays : United States
Organisme : NEI NIH HHS
ID : NEI T35EY007088
Pays : United States
Informations de copyright
© 2023 College of Optometrists.
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