IL-8 correlates with nonresponse to neoadjuvant nivolumab in HPV positive HNSCC via a potential extracellular vesicle miR-146a mediated mechanism.
chemokine
desmoglein
extracellular vesicle
immune checkpoint inhibitor
microRNA
Journal
Molecular carcinogenesis
ISSN: 1098-2744
Titre abrégé: Mol Carcinog
Pays: United States
ID NLM: 8811105
Informations de publication
Date de publication:
09 2023
09 2023
Historique:
revised:
19
05
2023
received:
15
05
2023
accepted:
23
05
2023
pmc-release:
01
09
2024
medline:
21
8
2023
pubmed:
4
7
2023
entrez:
4
7
2023
Statut:
ppublish
Résumé
Therapy using anti-PD-1 immune checkpoint inhibitors (ICI) has revolutionized the treatment of many cancers including head and neck squamous cell carcinomas (HNSCC), but only a fraction of patients respond. To better understand the molecular mechanisms driving resistance, we performed extensive analysis of plasma and tumor tissues before and after a 4-week neoadjuvant trial in which HNSCC patients were treated with the anti-PD-1 inhibitor, nivolumab. Luminex cytokine analysis of patient plasma demonstrated that HPV
Identifiants
pubmed: 37401875
doi: 10.1002/mc.23587
pmc: PMC10524928
mid: NIHMS1904836
doi:
Substances chimiques
Interleukin-8
0
Nivolumab
31YO63LBSN
MicroRNAs
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1428-1443Subventions
Organisme : NIAMS NIH HHS
ID : F31 AR080564
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA056036
Pays : United States
Organisme : NIAMS NIH HHS
ID : R01 AR074314
Pays : United States
Organisme : NIAAA NIH HHS
ID : T32 AA007463
Pays : United States
Informations de copyright
© 2023 The Authors. Molecular Carcinogenesis published by Wiley Periodicals LLC.
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