Circumstances, causes and timing of death in extremely preterm infants admitted to NICU: The EPIPAGE-2 study.
cause of death
end of life decision
extremely preterm infants
preterm birth
withdrawal
Journal
Acta paediatrica (Oslo, Norway : 1992)
ISSN: 1651-2227
Titre abrégé: Acta Paediatr
Pays: Norway
ID NLM: 9205968
Informations de publication
Date de publication:
10 2023
10 2023
Historique:
revised:
10
05
2023
received:
08
02
2023
accepted:
28
06
2023
medline:
11
9
2023
pubmed:
4
7
2023
entrez:
4
7
2023
Statut:
ppublish
Résumé
To describe the circumstances, causes and timing of death in extremely preterm infants. We included from the EPIPAGE-2 study infants born at 24-26 weeks in 2011 admitted to neonatal intensive care units (NICU). Vital status and circumstances of death were used to define three groups of infants: alive at discharge, death with or without withholding or withdrawing life-sustaining treatment (WWLST). The main cause of death was classified as respiratory disease, necrotizing enterocolitis, infection, central nervous system (CNS) injury, other or unknown. Among 768 infants admitted to NICU, 224 died among which 89 died without WWLST and 135 with WWLST. The main causes of death were respiratory disease (38%), CNS injury (30%) and infection (12%). Among the infants who died with WWLST, CNS injury was the main cause of death (47%), whereas respiratory disease (56%) and infection (20%) were the main causes in case of death without WWLST. Half (51%) of all deaths occurred within the first 7 days of life, and 35% occurred within 8 and 28 days. The death of extremely preterm infants in NICU is a complex phenomenon in which the circumstances and causes of death are intertwined.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2066-2074Subventions
Organisme : Agence Nationale de la Recherche
ID : ANR-11-EQPX-0038
Organisme : Agence Nationale de la Recherche
ID : ANR-19-COHO-001
Organisme : Fondation de France
ID : 11779
Organisme : Fondation pour la Recherche Médicale
ID : SPF20160936356
Organisme : Fondation PremUP
Organisme : French Institute of Public Health Research
Organisme : programme hospitalier de recherche clinique
ID : Epinutri (DGOS13-040
Informations de copyright
© 2023 Foundation Acta Paediatrica. Published by John Wiley & Sons Ltd.
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