Aerobic exercise reverses aging-induced depth-dependent decline in cerebral microcirculation.
aging
cerebral microcirculation
cerebral oxygenation
exercise
mouse
neuroscience
two-photon microscopy
white matter
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
04 07 2023
04 07 2023
Historique:
received:
20
01
2023
accepted:
16
06
2023
medline:
6
7
2023
pubmed:
4
7
2023
entrez:
4
7
2023
Statut:
epublish
Résumé
Aging is a major risk factor for cognitive impairment. Aerobic exercise benefits brain function and may promote cognitive health in older adults. However, underlying biological mechanisms across cerebral gray and white matter are poorly understood. Selective vulnerability of the white matter to small vessel disease and a link between white matter health and cognitive function suggests a potential role for responses in deep cerebral microcirculation. Here, we tested whether aerobic exercise modulates cerebral microcirculatory changes induced by aging. To this end, we carried out a comprehensive quantitative examination of changes in cerebral microvascular physiology in cortical gray and subcortical white matter in mice (3-6 vs. 19-21 months old), and asked whether and how exercise may rescue age-induced deficits. In the sedentary group, aging caused a more severe decline in cerebral microvascular perfusion and oxygenation in deep (infragranular) cortical layers and subcortical white matter compared with superficial (supragranular) cortical layers. Five months of voluntary aerobic exercise partly renormalized microvascular perfusion and oxygenation in aged mice in a depth-dependent manner, and brought these spatial distributions closer to those of young adult sedentary mice. These microcirculatory effects were accompanied by an improvement in cognitive function. Our work demonstrates the selective vulnerability of the deep cortex and subcortical white matter to aging-induced decline in microcirculation, as well as the responsiveness of these regions to aerobic exercise.
Identifiants
pubmed: 37402178
doi: 10.7554/eLife.86329
pii: 86329
pmc: PMC10319437
doi:
pii:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIH HHS
ID : U24EB028941
Pays : United States
Organisme : NIH HHS
ID : U19NS123717
Pays : United States
Organisme : NIH HHS
ID : U01HL133362
Pays : United States
Organisme : NIH HHS
ID : R00MH120053
Pays : United States
Organisme : NIH HHS
ID : R01NS115401
Pays : United States
Organisme : NIH HHS
ID : RF1NS121095
Pays : United States
Organisme : NIH HHS
ID : R01AG055413
Pays : United States
Commentaires et corrections
Type : UpdateOf
Informations de copyright
© 2023, Shin et al.
Déclaration de conflit d'intérêts
PS, QP, HI, GH, EM, SG, BF, MA, SA, IŞ, BL, CR, SV, CA, EL, KA, AD, SS No competing interests declared
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