Making human immune systems more interpretable through systems immunology.
human immunology
methods
systems immunology
translational research
Journal
Trends in immunology
ISSN: 1471-4981
Titre abrégé: Trends Immunol
Pays: England
ID NLM: 100966032
Informations de publication
Date de publication:
08 2023
08 2023
Historique:
received:
08
05
2023
revised:
12
06
2023
accepted:
12
06
2023
medline:
31
7
2023
pubmed:
5
7
2023
entrez:
4
7
2023
Statut:
ppublish
Résumé
The human immune system is a distributed system of specialized cell populations with unique functions that collectively give rise to immune responses to infections and during immune-mediated diseases. Cell composition, plasma proteins, and functional responses vary among individuals, making the system difficult to interpret, but this variation is nonrandom. With careful analyses using novel experimental and computational tools, human immune system composition and function carry interpretable information. Here, we propose that systems-level analyses offer an opportunity to make human immune responses more interpretable in the future, and we discuss herein important considerations and lessons learned to this end. Predictable human immunology holds implications for better diagnostic and curative precision in patients with infectious and immune-associated diseases.
Identifiants
pubmed: 37402600
pii: S1471-4906(23)00113-8
doi: 10.1016/j.it.2023.06.005
pii:
doi:
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
577-584Informations de copyright
Copyright © 2023 The Author(s). Published by Elsevier Ltd.. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests P.B. is a founder of Cytodelics AB (Stockholm, Sweden), executive board member of Kancera AB (Stockholm, Sweden), scientific advisor of Pixelgen Technologies AB (Stockholm, Sweden), Scailyte AG (Basel, Switzerland) and Oxford Immune Algorithmics Inc. (Oxford, UK) and Infinant Health Inc. (Davis, CA, USA).