Meningeal regulation of infections: A double-edged sword.
Central nervous system
infection
meninges
meningitis
neurological
Journal
European journal of immunology
ISSN: 1521-4141
Titre abrégé: Eur J Immunol
Pays: Germany
ID NLM: 1273201
Informations de publication
Date de publication:
09 2023
09 2023
Historique:
revised:
15
06
2023
received:
10
02
2023
accepted:
16
06
2023
medline:
11
9
2023
pubmed:
5
7
2023
entrez:
4
7
2023
Statut:
ppublish
Résumé
In the past 10 years, important discoveries have been made in the field of neuroimmunology, especially regarding brain borders. Indeed, meninges are protective envelopes surrounding the CNS and are currently in the spotlight, with multiple studies showing their involvement in brain infection and cognitive disorders. In this review, we describe the meningeal layers and their protective role in the CNS against bacterial, viral, fungal, and parasitic infections, by immune and nonimmune cells. Moreover, we discuss the neurological and cognitive consequences resulting from meningeal infections in neonates (e.g. infection with group B Streptococcus, cytomegalovirus, …) or adults (e.g. infection with Trypanosoma brucei, Streptococcus pneumoniae, …). We hope that this review will bring to light an integrated view of meningeal immune regulations during CNS infections and their neurological consequences.
Identifiants
pubmed: 37402972
doi: 10.1002/eji.202250267
doi:
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2250267Informations de copyright
© 2023 Wiley-VCH GmbH.
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