Effects of the loss of maternal gut microbiota before pregnancy on gut microbiota, food allergy susceptibility, and epigenetic modification on subsequent generations.
DNA methylation
Developmental Origins of Health and Disease
Treg (Regulatory T cell)
antibiotics
food allergy
gut microbiota
Journal
Bioscience of microbiota, food and health
ISSN: 2186-6953
Titre abrégé: Biosci Microbiota Food Health
Pays: Japan
ID NLM: 101578264
Informations de publication
Date de publication:
2023
2023
Historique:
received:
21
12
2022
accepted:
17
03
2023
medline:
5
7
2023
pubmed:
5
7
2023
entrez:
5
7
2023
Statut:
ppublish
Résumé
Maternal environments affect the health of offspring in later life. Changes in epigenetic modifications may partially explain this phenomenon. The gut microbiota is a critical environmental factor that influences epigenetic modifications of host immune cells and the development of food allergies. However, whether changes in the maternal gut microbiota affect the development of food allergies and related epigenetic modifications in subsequent generations remains unclear. Here, we investigated the effects of antibiotic treatment before pregnancy on the development of the gut microbiota, food allergies, and epigenetic modifications in F1 and F2 mice. We found that pre-conception antibiotic treatment affected the gut microbiota composition in F1 but not F2 offspring. F1 mice born to antibiotic-treated mothers had a lower proportion of butyric acid-producing bacteria and, consequently, a lower butyric acid concentration in their cecal contents. The methylation level in the DNA of intestinal lamina propria lymphocytes, food allergy susceptibility, and production of antigen-specific IgE in the F1 and F2 mice were not different between those born to control and antibiotic-treated mothers. In addition, F1 mice born to antibiotic-treated mothers showed increased fecal excretion related to the stress response in a novel environment. These results suggest that the maternal gut microbiota is effectively passed onto F1 offspring but has little effect on food allergy susceptibility or DNA methylation levels in offspring.
Identifiants
pubmed: 37404565
doi: 10.12938/bmfh.2022-093
pii: 2022-093
pmc: PMC10315195
doi:
Types de publication
Journal Article
Langues
eng
Pagination
203-212Informations de copyright
©2023 BMFH Press.
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