Detection of Myocardial Ischemia Using Cardiovascular MRI Stress T1 Mapping: A Miniature-Swine Validation Study.

Coronary Artery Disease MRI Myocardial Ischemia Rest T1 Mapping Stress T1 Mapping Swine Model

Journal

Radiology. Cardiothoracic imaging
ISSN: 2638-6135
Titre abrégé: Radiol Cardiothorac Imaging
Pays: United States
ID NLM: 101748663

Informations de publication

Date de publication:
Jun 2023
Historique:
received: 06 05 2022
revised: 30 03 2023
accepted: 18 04 2023
medline: 5 7 2023
pubmed: 5 7 2023
entrez: 5 7 2023
Statut: epublish

Résumé

To assess the efficacy of cardiac MRI stress T1 mapping in detecting ischemic and infarcted myocardium in a miniature-swine model, using pathologic findings as the reference standard. Ten adult male Chinese miniature swine, with coronary artery stenosis induced by an ameroid constrictor, and two healthy control swine were studied. Cardiac 3-T MRI rest and adenosine triphosphate stress T1 mapping and perfusion images, along with resting and late gadolinium enhancement images, were acquired at baseline and weekly up to 4 weeks after surgery or until humanely killed. A receiver operating characteristic analysis was used to analyze the performance of T1 mapping in the detection of myocardial ischemia. In the experimental group, both the infarcted myocardium (ΔT1 = 10 msec ± 2 [SD]; ΔT1 percentage = 0.7% ± 0.1) and ischemic myocardium (ΔT1 = 10 msec ± 2; ΔT1 percentage = 0.9% ± 0.2) exhibited reduced T1 reactivity compared with the remote myocardium (ΔT1 = 53 msec ± 7; ΔT1 percentage = 4.7% ± 0.6) and normal myocardium (ΔT1 = 56 msec ± 11; ΔT1 percentage = 4.9% ± 1.1). Receiver operating characteristic analysis demonstrated high diagnostic performance of ΔT1 in detecting ischemic myocardium, with an area under the curve (AUC) of 0.84 ( Using histopathologic validation in a swine model, noninvasive cardiac MRI stress T1 mapping demonstrated high performance in detecting ischemic and infarcted myocardium without the need for contrast agents.

Identifiants

DOI: 10.1148/ryct.220092 PMID: 37404782 PMC: PMC10316297
pubmed: 37404782
doi: 10.1148/ryct.220092
pmc: PMC10316297
doi:

Types de publication

Journal Article

Langues

eng

Pagination

e220092

Informations de copyright

© 2023 by the Radiological Society of North America, Inc.

Déclaration de conflit d'intérêts

Disclosures of conflicts of interest: B.Z. No relevant relationships. C.C. No relevant relationships. J.H. No relevant relationships. J.X. No relevant relationships. G.Y. No relevant relationships. X.D. No relevant relationships. G.Y. No relevant relationships. H.W. No relevant relationships. X.W. No relevant relationships. A.S. No relevant relationships. S.Z. No relevant relationships. M.L. No relevant relationships.

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Auteurs

Baiyan Zhuang (B)

From the Department of Magnetic Resonance Imaging, Cardiovascular Imaging and Intervention Center (B.Z., C.C., J.H., J.X., G.Y., S.Z., M.L.), Department of Pathology (X.D., H.W.), and Department of Animal Experimental Center (G.Y., X.W.), Fuwai Hospital, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, People's Republic of China; National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Md (A.S., M.L.); and Key Laboratory of Cardiovascular Imaging (Cultivation), Chinese Academy of Medical Sciences, Beijing, People's Republic of China (M.L.).
ORCID: 0000-0003-3873-4950

Chen Cui (C)

From the Department of Magnetic Resonance Imaging, Cardiovascular Imaging and Intervention Center (B.Z., C.C., J.H., J.X., G.Y., S.Z., M.L.), Department of Pathology (X.D., H.W.), and Department of Animal Experimental Center (G.Y., X.W.), Fuwai Hospital, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, People's Republic of China; National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Md (A.S., M.L.); and Key Laboratory of Cardiovascular Imaging (Cultivation), Chinese Academy of Medical Sciences, Beijing, People's Republic of China (M.L.).
ORCID: 0000-0002-8996-6623

Jian He (J)

From the Department of Magnetic Resonance Imaging, Cardiovascular Imaging and Intervention Center (B.Z., C.C., J.H., J.X., G.Y., S.Z., M.L.), Department of Pathology (X.D., H.W.), and Department of Animal Experimental Center (G.Y., X.W.), Fuwai Hospital, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, People's Republic of China; National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Md (A.S., M.L.); and Key Laboratory of Cardiovascular Imaging (Cultivation), Chinese Academy of Medical Sciences, Beijing, People's Republic of China (M.L.).
ORCID: 0000-0001-6899-5145

Jing Xu (J)

From the Department of Magnetic Resonance Imaging, Cardiovascular Imaging and Intervention Center (B.Z., C.C., J.H., J.X., G.Y., S.Z., M.L.), Department of Pathology (X.D., H.W.), and Department of Animal Experimental Center (G.Y., X.W.), Fuwai Hospital, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, People's Republic of China; National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Md (A.S., M.L.); and Key Laboratory of Cardiovascular Imaging (Cultivation), Chinese Academy of Medical Sciences, Beijing, People's Republic of China (M.L.).

Gang Yin (G)

From the Department of Magnetic Resonance Imaging, Cardiovascular Imaging and Intervention Center (B.Z., C.C., J.H., J.X., G.Y., S.Z., M.L.), Department of Pathology (X.D., H.W.), and Department of Animal Experimental Center (G.Y., X.W.), Fuwai Hospital, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, People's Republic of China; National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Md (A.S., M.L.); and Key Laboratory of Cardiovascular Imaging (Cultivation), Chinese Academy of Medical Sciences, Beijing, People's Republic of China (M.L.).

Xuejing Duan (X)

From the Department of Magnetic Resonance Imaging, Cardiovascular Imaging and Intervention Center (B.Z., C.C., J.H., J.X., G.Y., S.Z., M.L.), Department of Pathology (X.D., H.W.), and Department of Animal Experimental Center (G.Y., X.W.), Fuwai Hospital, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, People's Republic of China; National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Md (A.S., M.L.); and Key Laboratory of Cardiovascular Imaging (Cultivation), Chinese Academy of Medical Sciences, Beijing, People's Republic of China (M.L.).

Guangxin Yue (G)

From the Department of Magnetic Resonance Imaging, Cardiovascular Imaging and Intervention Center (B.Z., C.C., J.H., J.X., G.Y., S.Z., M.L.), Department of Pathology (X.D., H.W.), and Department of Animal Experimental Center (G.Y., X.W.), Fuwai Hospital, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, People's Republic of China; National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Md (A.S., M.L.); and Key Laboratory of Cardiovascular Imaging (Cultivation), Chinese Academy of Medical Sciences, Beijing, People's Republic of China (M.L.).

Hongyue Wang (H)

From the Department of Magnetic Resonance Imaging, Cardiovascular Imaging and Intervention Center (B.Z., C.C., J.H., J.X., G.Y., S.Z., M.L.), Department of Pathology (X.D., H.W.), and Department of Animal Experimental Center (G.Y., X.W.), Fuwai Hospital, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, People's Republic of China; National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Md (A.S., M.L.); and Key Laboratory of Cardiovascular Imaging (Cultivation), Chinese Academy of Medical Sciences, Beijing, People's Republic of China (M.L.).

Xin Wang (X)

From the Department of Magnetic Resonance Imaging, Cardiovascular Imaging and Intervention Center (B.Z., C.C., J.H., J.X., G.Y., S.Z., M.L.), Department of Pathology (X.D., H.W.), and Department of Animal Experimental Center (G.Y., X.W.), Fuwai Hospital, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, People's Republic of China; National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Md (A.S., M.L.); and Key Laboratory of Cardiovascular Imaging (Cultivation), Chinese Academy of Medical Sciences, Beijing, People's Republic of China (M.L.).

Arlene Sirajuddin (A)

From the Department of Magnetic Resonance Imaging, Cardiovascular Imaging and Intervention Center (B.Z., C.C., J.H., J.X., G.Y., S.Z., M.L.), Department of Pathology (X.D., H.W.), and Department of Animal Experimental Center (G.Y., X.W.), Fuwai Hospital, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, People's Republic of China; National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Md (A.S., M.L.); and Key Laboratory of Cardiovascular Imaging (Cultivation), Chinese Academy of Medical Sciences, Beijing, People's Republic of China (M.L.).
ORCID: 0000-0001-9183-5983

Shihua Zhao (S)

From the Department of Magnetic Resonance Imaging, Cardiovascular Imaging and Intervention Center (B.Z., C.C., J.H., J.X., G.Y., S.Z., M.L.), Department of Pathology (X.D., H.W.), and Department of Animal Experimental Center (G.Y., X.W.), Fuwai Hospital, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, People's Republic of China; National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Md (A.S., M.L.); and Key Laboratory of Cardiovascular Imaging (Cultivation), Chinese Academy of Medical Sciences, Beijing, People's Republic of China (M.L.).
ORCID: 0000-0002-7798-0364

Minjie Lu (M)

From the Department of Magnetic Resonance Imaging, Cardiovascular Imaging and Intervention Center (B.Z., C.C., J.H., J.X., G.Y., S.Z., M.L.), Department of Pathology (X.D., H.W.), and Department of Animal Experimental Center (G.Y., X.W.), Fuwai Hospital, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, People's Republic of China; National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Md (A.S., M.L.); and Key Laboratory of Cardiovascular Imaging (Cultivation), Chinese Academy of Medical Sciences, Beijing, People's Republic of China (M.L.).
ORCID: 0000-0001-8696-318X

Classifications MeSH