Informatics on Drug Repurposing for Breast Cancer.

Moving a new drug from bench to bedside is a long and arduous process. The tactic of drug repurposing, which solves "new" diseases with "old" existing drugs, is more efficient and economical than conventional ab-initio way for drug development. Information technology has dramatically changed the paradigm of biomedical research in the new century, and drug repurposing studies have been significantly accelerated by implementing informatics techniques related to genomics, systems biology and biophysics during the past few years. A series of remarkable achievements in this field comes with the practical applications of in silico approaches including transcriptomic signature matching, gene-connection-based scanning, and simulated structure docking in repositioning drug therapies against breast cancer. In this review, we systematically curated these impressive accomplishments with summarization of the main findings on potentially repurposable drugs, and provide our insights into the current issues as well as future directions of the field. With the prospective improvement in reliability, the computer-assisted repurposing strategy will play a more critical role in drug research and development.

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© 2023 Zhou et al.

Déclaration de conflit d'intérêts

H.L., Y.Y. and X.Y. are all employees of Changsha Kingmed Center for Clinical Laboratory. X.Y. is also an employee of Guangzhou Kingmed Center for Clinical Laboratory. All other authors declare no financial or non-financial competing interests in this work.