Effusion cytology of metastatic carcinosarcoma.
Ascitic fluid
Carcinosarcoma
Cell block
Effusion cytology
Immunocytochemistry
Journal
CytoJournal
ISSN: 0974-5963
Titre abrégé: Cytojournal
Pays: United States
ID NLM: 101231642
Informations de publication
Date de publication:
2023
2023
Historique:
received:
21
08
2022
accepted:
01
10
2022
medline:
5
7
2023
pubmed:
5
7
2023
entrez:
5
7
2023
Statut:
epublish
Résumé
Carcinosarcomas (CSs) are rare gynecological neoplasms seen in elderly females. These are composed of malignant epithelial and mesenchymal components, which appear as adenocarcinoma and high-grade sarcoma. Effusions are encountered uncommonly in CS. The study focuses on the cytomorphology of 10 cases of metastatic CS in effusions. In 6 years, there were 10 (0.45%) cases of metastatic CS in effusion samples out of 2240 malignant effusion samples. The samples were processed by SurePath The cells were predominantly arranged in ball-like clusters and discretely. The cells had abundant vacuolated cytoplasm and enlarged pleomorphic nuclei. Occasional cases showed scattered spindle cells. The cases were diagnosed as metastatic adenocarcinoma (7/10) and positive for malignant cells (3/10). None of the cases was diagnosed as CS. The primary of these cases was in the uterus (7/10) and ovary (3/10). The cytological evaluation of such effusion samples rarely demonstrates the classical biphasic pattern of these tumors. Mostly, the carcinomatous component is evident, and the sarcomatous element is inapparent and readily missed.
Identifiants
pubmed: 37405308
doi: 10.25259/Cytojournal_30_2022
pii: 10.25259/Cytojournal_30_2022
pmc: PMC10316228
doi:
Types de publication
Journal Article
Langues
eng
Pagination
14Informations de copyright
© 2023 Cytopathology Foundation Inc, Published by Scientific Scholar.
Déclaration de conflit d'intérêts
The authors do not have any conflicts of interest.
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