A comparison of results from antihuman globulin-graded reactions with the monocyte monolayer assay.
antiglobulin
antihuman globulin (AHG)
extravascular/intravascular hemolysis
monocyte index (MI)
monocyte monolayer assay (MMA)
Journal
Immunohematology
ISSN: 0894-203X
Titre abrégé: Immunohematology
Pays: United States
ID NLM: 8806387
Informations de publication
Date de publication:
01 Jun 2023
01 Jun 2023
Historique:
medline:
7
7
2023
pubmed:
5
7
2023
entrez:
5
7
2023
Statut:
epublish
Résumé
Blood transfusions are a common medical treatment. Risks arise when compatible blood is not available. This study assesses the correlation between antibody reaction strength at the antihuman globulin (AHG) phase of testing and the antibody clinical significance as predicted using the monocyte monolayer assay (MMA). Multiple examples of anti-K donor plasma samples were selected to sensitize K+k+ red blood cells (RBCs). Reactivity was confirmed by testing the sensitized K+k+ RBCs at saline-AHG. Antibody titers were determined by serial dilution using neat plasma. Sixteen samples were selected for the study based on comparable graded reactions with neat plasma (1+, 2+, 3+, and 4+) and similar titration endpoints. Each sample was used to sensitize the same Kk donor and then tested by monocytes to evaluate the clinical significance using the MMA, an
Identifiants
pubmed: 37405849
pii: immunohematology-2023-013
doi: 10.21307/immunohematology-2023-013
doi:
Substances chimiques
Antibodies
0
Blood Group Antigens
0
Isoantibodies
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
77-81Informations de copyright
© 2023 K. Bowman et al., published by Sciendo.
Références
Giangrande PL. Historical review: the history of blood transfusion. Br J Haematol 2000;110:758–67. doi: 10.1046/j.1365-2141.2000.02139.x
doi: 10.1046/j.1365-2141.2000.02139.x
Mandal A, Robertson S. History of blood transfusion. News Medical Life Sciences. February 26, 2019. Available from https://www.news-medical.net/health/History-of-Blood-Transfusion.aspx. Accessed 21 October 2021.
Reid ME, Shine I. The discovery and significance of the blood groups. Cambridge, MA: SBB Books, 2012.
Pierce SR, Reid ME. Bloody brilliant: a history of blood groups and blood groupers. Bethesda, MD: AABB, 2016.
Blundell J. Experiments on the transfusion of blood by the syringe. Med Chir Trans 1818;9:56–92. doi: 10.1177/09595287180090p107
doi: 10.1177/09595287180090p107
Ottenberg R. Reminiscences of the history of blood transfusion. J Mt. Sinai Hosp NY 1937;4:264–71.
Issitt PD, Anstee DJ. Applied blood group serology. 4th ed. Durham, NC: Montgomery Scientific, 1998.
Coombs RRA, Mourant AE, Race RR. Detection of weak and incomplete Rh agglutinins: a new test. Lancet 1945;2:15.
Coombs RRA, Mourant AE, Race RR. A new test for the detection of weak and incomplete Rh agglutinins. Br J Exp Pathol 1945;26:255.
Harmening DM. Modern blood banking and transfusion practices. 7th ed. Philadelphia, PA: F.A. Davis Company, 2019.
Poole J, Daniels G. Blood group antibodies and their significance in transfusion medicine. Transfus Med Rev 2007;21: 58–71.
Cohn CS, Delaney M, Johnson ST, Katz LM. AABB technical manual. 20th ed. Bethesda, MD: AABB, 2020.
Maral S, Bakanay SM, Akinci S, Yikilmaz AS, Comert P, Dilek I. The least incompatible crossmatch red blood cell transfusion by biological compatibility test. Glob J Transfus Med 2019;4: 154–7.
Petz LD, Garratty G. Immune hemolytic anemias. 2nd ed. Philadelphia, PA: Churchill Livingstone, 2004.
Schanfield MS, Stevens JO, Bauman D. The detection of clinically significant erythrocyte alloantibodies using a human mononuclear phagocyte assay. Transfusion 1981;21:571–6. doi: 10.1046/j.1537-2995.1981.21582040822.x
doi: 10.1046/j.1537-2995.1981.21582040822.x
Flegel WA. Pathogenesis and mechanisms of antibody-mediated hemolysis. Transfusion 2015;55:S47–58.
Noumsi GT, Billingsley KL, Moulds JM. Successful transfusion of antigen positive blood to alloimmunised patients using a monocyte monolayer assay. Transfus Med 2015;25:92–100.
Arndt PA, Garratty G. A retrospective analysis of the value of monocyte monolayer assay results for predicting the clinical significance of blood group alloantibodies. Transfusion 2004; 44:1273–81.
Nance S, Arndt P, Garratty G. Predicting the clinical significance of red cell alloantibodies using a monocyte monolayer assay. Transfusion 1987;27:449–52.
Maurer J, Nance S, Nickle P. Relationship of antibody reactivity strength to reactivity in the monocyte monolayer assay (MMA). Transfusion 2018;58:187.
Hunt JS, Beck ML, Hardman JT, Tegtmeier GE, Bayer WL. Characterization of human erythrocyte alloantibodies by IgG subclass and monocyte interaction. Am J Clin Pathol 1980;74:259–64. doi: 10.1093/ajcp/74.3.259
doi: 10.1093/ajcp/74.3.259
AuBuchon JP, Brightman A, Anderson HJ, Kim B. An example of Anti-Yta demonstrating a change in its clinical significance. Vox Sang 1988;55:171–5.
Nance S, Scandone P, Fassl L, et al. Monocyte monolayer assay (MMA) results are affected by transfusion of incompatible red cells (abstract). Transfusion 1997;37(Suppl):37S.
Branch DR, Sandhu G, Raos M. Monocyte monolayer predictions of clinical outcome for serologically incompatible red blood cells is all about timing. Transfusion 2021;61: 2516–7.