Cellular senescence implication in mustard keratopathy.

Humans Animals Mice Chemical Warfare Agents / toxicity Mustard Gas / toxicity Mechlorethamine / toxicity Corneal Diseases / pathology Cornea / metabolism Cellular Senescence
Aging Beta-galactosidase Mustard gas Mustard keratopathy Nitrogen mustard Ocular surface Senescence

Journal

Experimental eye research
ISSN: 1096-0007
Titre abrégé: Exp Eye Res
Pays: England
ID NLM: 0370707

Informations de publication

Date de publication:
08 2023
Historique:
received: 15 05 2023
revised: 28 06 2023
accepted: 01 07 2023
pmc-release: 01 08 2024
medline: 24 7 2023
pubmed: 6 7 2023
entrez: 5 7 2023
Statut: ppublish

Résumé

Mustard agents are vesicants that were used in warfare multiple times. They are potent alkylating agents that activate cellular pathways of apoptosis, increase oxidative stress, and induce inflammation. Eyes are particularly susceptible to mustard exposure with a wide range of ocular surface damage. Three main categories of mustard-related eye injuries are acute, chronic, and delayed-onset manifestations. Mustard keratopathy (MK) is a known complication characterized by corneal opacification, ulceration, thinning, and neovascularization that can lead to severe vision loss and discomfort. Recently, a few reports demonstrated the role of senescence induction as a new pathological mechanism in mustard-related injuries that could affect wound healing. We ran the first murine model of delayed-onset MK and nitrogen mustard-induced senescence, evaluating the pathological signs of senescence in the cornea using beta-galactosidase staining. Our results suggest that nitrogen mustard exposure causes senescence in the corneal cells, which could be the underlying mechanism for chronic and late-onset ocular surface damage. We also found a significant correlation between the percentage of positive beta-galactosidase staining and the degree of fibrosis in the cornea. This provides valuable insight into the possible role of anti-senescence drugs in the near future for accelerating corneal healing and restricting fibrosis in patients with mustard keratopathy.

Identifiants

DOI: 10.1016/j.exer.2023.109565 PMID: 37406956 PMC: PMC10392783
pubmed: 37406956
pii: S0014-4835(23)00186-0
doi: 10.1016/j.exer.2023.109565
pmc: PMC10392783
mid: NIHMS1916966
pii:
doi:

Substances chimiques

Chemical Warfare Agents 0
Mustard Gas T8KEC9FH9P
Mechlorethamine 50D9XSG0VR

Types de publication

Journal Article Research Support, U.S. Gov't, Non-P.H.S. Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

109565

Subventions

Organisme : NEI NIH HHS
ID : P30 EY001792
Pays : United States
Organisme : NEI NIH HHS
ID : R01 EY024349
Pays : United States
Organisme : NEI NIH HHS
ID : UH3 EY031809
Pays : United States

Informations de copyright

Copyright © 2023 Elsevier Ltd. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of competing interest The authors declare that they have no competing interests.

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Auteurs

Mohammad Soleimani (M)

Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, IL, USA; Eye Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran. Electronic address: msolei2@uic.edu.

Seyed Mahbod Baharnoori (SM)

Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, IL, USA; Eye Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran. Electronic address: sbahar2@uic.edu.

Kasra Cheraqpour (K)

Eye Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran. Electronic address: cheraqpourk@gmail.com.

Bita Momenaei (B)

Wills Eye Hospital, Mid Atlantic Retina, Thomas Jefferson University, Philadelphia, PA, USA. Electronic address: bmomenaei@midatlanticretina.com.

Reza Mirshahi (R)

Eye Research Center, The Five Senses Health Institute, Rasoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran. Electronic address: rezamirshahi@gmail.com.

Collin Chow (C)

Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, IL, USA. Electronic address: colin.chow@my.rfums.org.

Sumaiya Shahjahan (S)

Des Moines University, Des Moines, IA, USA. Electronic address: sumaiyaa522@gmail.com.

Tara Nguyen (T)

Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, IL, USA. Electronic address: tnguye40@uic.edu.

Mohammad Javad Ashraf (MJ)

Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, IL, USA. Electronic address: mashra5@uic.edu.

Xiaoke Huang (X)

Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, IL, USA. Electronic address: xiaokeh@uic.edu.

Raghuram Koganti (R)

Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, IL, USA. Electronic address: rkogan3@uic.edu.

Makan Cheraghpour (M)

Basic and Molecular Epidemiology of Gastrointestinal Disorders Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address: bio_makan@yahoo.com.

Mahmood Ghassemi (M)

Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, IL, USA. Electronic address: ghassemi@uic.edu.

Ali R Djalilian (AR)

Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, IL, USA. Electronic address: adjalili@uic.edu.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Cellular senescence implication in mustard keratopathy.
questionsmedicales.fr › Eucaryotes › Animaux › Cellular senescence implication in mustard keratopathy.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Cellular senescence implication in mustard keratopathy.
questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Armes › Armes de destruction massive › Armes chimiques › Cellular senescence implication in mustard keratopathy.
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures halogénés › Moutardes › Gaz moutarde › Cellular senescence implication in mustard keratopathy.
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures halogénés › Moutardes › Moutardes à l'azote › Chlorméthine › Cellular senescence implication in mustard keratopathy.
questionsmedicales.fr › Maladies de l'oeil › Maladies de la cornée › Cellular senescence implication in mustard keratopathy.
questionsmedicales.fr › Organes des sens › Oeil › Pôle antérieur du bulbe oculaire › Cornée › Cellular senescence implication in mustard keratopathy.
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Vieillissement › Vieillissement de la cellule › Cellular senescence implication in mustard keratopathy.