Secondary Iron Overload and the Liver: A Comprehensive Review.
Cirrhosis
Hemochromatosis
Hepatocellular carcinoma
Iron overload
Thalassemia
Journal
Journal of clinical and translational hepatology
ISSN: 2310-8819
Titre abrégé: J Clin Transl Hepatol
Pays: United States
ID NLM: 101649815
Informations de publication
Date de publication:
28 Aug 2023
28 Aug 2023
Historique:
received:
29
08
2022
revised:
20
10
2022
accepted:
04
01
2023
medline:
6
7
2023
pubmed:
6
7
2023
entrez:
6
7
2023
Statut:
ppublish
Résumé
Iron overload is a condition involving excessive iron deposit in various organs, the liver being the main target organ for iron deposition and overload which are associated with significant liver morbidity and mortality. Iron overload can be categorized into primary and secondary causes. Primary iron overload, so-called hereditary hemochromatosis, is a well-recognized disease with available standard treatment recommendations. However, secondary iron overload is a more diverse disease with many unclear areas to be explored. Secondary iron overload is more prevalent than primary iron overload and occurs as a consequence of various causes which differ significantly across geographic regions. The main causes of secondary iron overload are iron-loading anemias, and chronic liver disease. The liver-related outcomes, patient outcomes, and treatment recommendations in these patients differ depending on the cause of iron overload. This review summarizes the causes, pathophysiology, liver-related outcomes, disease outcomes, and treatments of secondary iron overload.
Identifiants
pubmed: 37408825
doi: 10.14218/JCTH.2022.00420
pii: JCTH.2022.00420
pmc: PMC10318281
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
932-941Informations de copyright
© 2023 Authors.
Déclaration de conflit d'intérêts
The authors have no conflict of interests related to this publication.
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