Inflammation biomarkers IL‑6 and IL‑10 may improve the diagnostic and prognostic accuracy of currently authorized traumatic brain injury tools.
biomarkers
interleukin 10
interleukin 6
interleukin 8
neuroinflammation
traumatic brain injury
Journal
Experimental and therapeutic medicine
ISSN: 1792-1015
Titre abrégé: Exp Ther Med
Pays: Greece
ID NLM: 101531947
Informations de publication
Date de publication:
Aug 2023
Aug 2023
Historique:
received:
02
02
2023
accepted:
04
04
2023
medline:
6
7
2023
pubmed:
6
7
2023
entrez:
6
7
2023
Statut:
epublish
Résumé
Traumatic brain injury (TBI) is currently one of the leading causes of mortality and disability worldwide. At present, no reliable inflammatory or specific molecular neurobiomarker exists in any of the standard models proposed for TBI classification or prognostication. Therefore, the present study was designed to assess the value of a group of inflammatory mediators for evaluating acute TBI, in combination with clinical, laboratory and radiological indices and prognostic clinical scales. In the present single-centre, prospective observational study, 109 adult patients with TBI, 20 adult healthy controls and a pilot group of 17 paediatric patients with TBI from a Neurosurgical Department and two intensive care units of University General Hospital of Heraklion, Greece were recruited. Blood measurements using the ELISA method, of cytokines IL-6, IL-8 and IL-10, ubiquitin C-terminal hydrolase L1 (UCH-L1) and glial fibrillary acidic protein, were performed. Compared with those in healthy control individuals, elevated IL-6 and IL-10 but reduced levels of IL-8 were found on day 1 in adult patients with TBI. In terms of TBI severity classifications, higher levels of IL-6 (P=0.001) and IL-10 (P=0.009) on day 1 in the adult group were found to be associated with more severe TBI according to widely used clinical and functional scales. Moreover, elevated IL-6 and IL-10 in adults were found to be associated with more serious brain imaging findings (r
Identifiants
pubmed: 37408863
doi: 10.3892/etm.2023.12063
pii: ETM-26-2-12063
pmc: PMC10318605
doi:
Types de publication
Journal Article
Langues
eng
Pagination
364Informations de copyright
Copyright: © Tsitsipanis et al.
Déclaration de conflit d'intérêts
The authors declare that they have no competing interests.
Références
Biomark Res. 2021 Sep 16;9(1):70
pubmed: 34530937
Br J Anaesth. 1997 May;78(5):520-3
pubmed: 9175965
Cell Transplant. 2017 Jul;26(7):1118-1130
pubmed: 28933211
J Neurosci Res. 2020 Jan;98(1):19-28
pubmed: 30259550
Intensive Care Med. 2007 Feb;33(2):255-60
pubmed: 17143637
Eur J Med Res. 2008 Oct 27;13(10):464-8
pubmed: 19008173
Nan Fang Yi Ke Da Xue Xue Bao. 2009 May;29(5):999-1001
pubmed: 19460731
BMJ. 2008 Feb 23;336(7641):425-9
pubmed: 18270239
Emerg Med J. 2022 Mar;39(3):206-212
pubmed: 34916280
Cureus. 2022 Apr 4;14(4):e23804
pubmed: 35392277
Crit Care Med. 2002 Dec;30(12):2669-74
pubmed: 12483057
Expert Rev Mol Diagn. 2018 Feb;18(2):165-180
pubmed: 29338452
Infect Immun. 1992 Jul;60(7):2835-42
pubmed: 1612748
Immunobiology. 2016 Mar;221(3):427-31
pubmed: 26688509
Clin Chim Acta. 2017 Jun;469:99-104
pubmed: 28366792
Cureus. 2021 Aug 10;13(8):e17056
pubmed: 34522534
Physiol Res. 2009;58(2):263-268
pubmed: 18380546
Glia. 2020 May;68(5):999-1016
pubmed: 31799746
Front Neurol. 2017 Jun 12;8:244
pubmed: 28659854
J Neurotrauma. 2021 Apr 15;38(8):1151-1163
pubmed: 31880977
World Neurosurg. 2018 Oct;118:e534-e542
pubmed: 30257306
PLoS One. 2013 Jul 24;8(7):e68963
pubmed: 23894384
Nat Rev Neurol. 2018 Dec;14(12):711-722
pubmed: 30397256
Neurology. 2020 Sep 1;95(9):e1126-e1133
pubmed: 32571850
J Neuroimmunol. 1999 Nov 15;101(2):211-21
pubmed: 10580806
J Clin Neurosci. 2019 Dec;70:37-41
pubmed: 31558362
Ann Neurol. 2020 Jun;87(6):907-920
pubmed: 32215965
Neurosurgery. 2011 Jan;68(1):12-9; discussion 19
pubmed: 21150751
Front Immunol. 2016 Dec 05;7:556
pubmed: 27994591
J Exp Med. 2020 May 4;217(5):
pubmed: 32267936
BMC Neurol. 2020 May 25;20(1):209
pubmed: 32450801
Acute Med Surg. 2021 Jan 19;8(1):e622
pubmed: 33510896
Ulus Travma Acil Cerrahi Derg. 2019 Mar;25(2):193-197
pubmed: 30892675
Crit Care. 2016 Sep 15;20:288
pubmed: 27630085
Arch Phys Med Rehabil. 2010 Nov;91(11):1637-40
pubmed: 21044706
Transl Psychiatry. 2022 Feb 26;12(1):80
pubmed: 35217643
Lancet Neurol. 2022 Sep;21(9):803-813
pubmed: 35963263
World Neurosurg. 2016 Mar;87:8-20
pubmed: 26547005
Neuroscientist. 2015 Aug;21(4):424-41
pubmed: 25059577
J Neurotrauma. 1997 Jul;14(7):451-7
pubmed: 9257663
J Trauma. 2002 Feb;52(2):339-45
pubmed: 11834998
Front Neurol. 2013 Mar 04;4:18
pubmed: 23459929
J Head Trauma Rehabil. 2020 Sep/Oct;35(5):324-331
pubmed: 32881766
J Trauma. 2009 Jun;66(6):1591-7; discussion 1598
pubmed: 19509619
Brain Behav Immun. 2022 Feb;100:83-87
pubmed: 34848337
Neuroimmunomodulation. 2012;19(6):377-85
pubmed: 23075771
Mini Rev Med Chem. 2009 Feb;9(2):227-34
pubmed: 19200027
Clin Chim Acta. 2018 May;480:84-91
pubmed: 29408171
J Neurotrauma. 2001 May;18(5):491-8
pubmed: 11393252
Acta Neurochir Suppl. 1997;70:96-7
pubmed: 9416290
Biomolecules. 2021 Oct 25;11(11):
pubmed: 34827575
Int J Legal Med. 2018 Mar;132(2):531-539
pubmed: 29306988
J Cell Mol Med. 2019 Aug;23(8):5211-5224
pubmed: 31162801
Brain Inj. 2014;28(10):1311-6
pubmed: 24830571
J Neurotrauma. 2021 Jan 1;38(1):53-62
pubmed: 32600167
J Neurotrauma. 2019 Oct 15;36(20):2863-2871
pubmed: 30794101
Am Fam Physician. 2022 Mar 1;105(3):313-314
pubmed: 35289582
Brain. 2004 Feb;127(Pt 2):315-20
pubmed: 14645145
J Neurotrauma. 2019 Jul 15;36(14):2178-2189
pubmed: 30760178
Neuroscientist. 2020 Oct-Dec;26(5-6):402-414
pubmed: 32684080
BMC Neurol. 2016 Sep 26;16(1):185
pubmed: 27671345
J Neurotrauma. 2019 Oct 15;36(20):2904-2912
pubmed: 31111795
Shock. 2020 Jan;53(1):24-34
pubmed: 30939502
Sci Adv. 2021 Mar 12;7(11):
pubmed: 33712456
Biochem Cell Biol. 2018 Aug;96(4):391-406
pubmed: 29370536
J Periodontol. 1993 May;64(5 Suppl):456-60
pubmed: 8315568
Crit Care Med. 2000 Apr;28(4):929-34
pubmed: 10809261
Neural Regen Res. 2022 Dec;17(12):2717-2724
pubmed: 35662219
Med Clin North Am. 2020 Mar;104(2):213-238
pubmed: 32035565
Neurosurg Rev. 2022 Oct;45(5):3035-3054
pubmed: 35790656
Front Neurol. 2020 Jun 02;11:376
pubmed: 32581990
Front Neurol. 2020 Oct 30;11:549527
pubmed: 33192979
J Neurol. 2019 Nov;266(11):2878-2889
pubmed: 31563989
Clin Diagn Lab Immunol. 1996 Nov;3(6):654-62
pubmed: 8914755
Neurosurg Clin N Am. 2016 Oct;27(4):397-407
pubmed: 27637392
Front Neurol. 2017 Jul 03;8:300
pubmed: 28717351
Clin Neurol Neurosurg. 2016 Oct;149:1-5
pubmed: 27450760
J Neurotrauma. 2020 Oct 1;37(19):2120-2130
pubmed: 32326805
Cell Mol Neurobiol. 2017 May;37(4):571-585
pubmed: 27383839
J Neuroinflammation. 2010 Mar 11;7:19
pubmed: 20222971
Behav Brain Res. 2020 Aug 17;392:112715
pubmed: 32470481
Br J Pharmacol. 2016 Feb;173(4):692-702
pubmed: 25752446
J Neurotrauma. 2002 Aug;19(8):929-37
pubmed: 12225653
Brain Behav Immun. 2017 Oct;65:90-94
pubmed: 28232173
Surg Clin North Am. 2017 Oct;97(5):1015-1030
pubmed: 28958355
Eur J Paediatr Neurol. 2008 May;12(3):195-204
pubmed: 17881264
Br J Sports Med. 2018 Feb;52(3):192-198
pubmed: 28918391
Brain Behav Immun. 2015 Mar;45:253-62
pubmed: 25555531
CNS Neurosci Ther. 2022 Dec;28(12):2044-2052
pubmed: 36017774
Brain Res. 1996 Mar 25;713(1-2):143-52
pubmed: 8724985
Front Neurol. 2022 Mar 21;13:835597
pubmed: 35386417
Phys Med Rehabil Clin N Am. 2017 May;28(2):215-225
pubmed: 28390509
J Biol Chem. 2006 Jan 6;281(1):199-205
pubmed: 16251188
Cold Spring Harb Perspect Biol. 2018 Feb 1;10(2):
pubmed: 28620096
Comput Math Methods Med. 2017;2017:3762651
pubmed: 28642804
Childs Nerv Syst. 2005 Mar;21(3):185-93; discussion 194
pubmed: 15455248
Neuron. 2017 Sep 13;95(6):1246-1265
pubmed: 28910616
Neurosurg Rev. 2022 Apr;45(2):1171-1193
pubmed: 34709508
PLoS One. 2018 Jul 9;13(7):e0200394
pubmed: 29985933
J Neurosurg. 2016 Sep;125(3):631-41
pubmed: 26722854
Cytokine. 2022 May;153:155828
pubmed: 35247648
Tohoku J Exp Med. 2007 Apr;211(4):387-93
pubmed: 17409679
Curr Med Chem. 2006;13(30):3719-31
pubmed: 17168733
Shock. 2004 Aug;22(2):102-7
pubmed: 15257081
Cytokine. 1989 Nov;1(1):2-13
pubmed: 2491503