Targeting sterol-O-acyltransferase 1 to disrupt cholesterol metabolism for cancer therapy.
avasimibe
cancer therapy
cholesterol esterification
cholesterol metabolism
sterol-O-acyltransferase 1
Journal
Frontiers in oncology
ISSN: 2234-943X
Titre abrégé: Front Oncol
Pays: Switzerland
ID NLM: 101568867
Informations de publication
Date de publication:
2023
2023
Historique:
received:
31
03
2023
accepted:
05
06
2023
medline:
6
7
2023
pubmed:
6
7
2023
entrez:
6
7
2023
Statut:
epublish
Résumé
Cholesterol esterification is often dysregulated in cancer. Sterol O-acyl-transferase 1 (SOAT1) plays an important role in maintaining cellular cholesterol homeostasis by catalyzing the formation of cholesterol esters from cholesterol and long-chain fatty acids in cells. Many studies have implicated that SOAT1 plays a vital role in cancer initiation and progression and is an attractive target for novel anticancer therapy. In this review, we provide an overview of the mechanism and regulation of SOAT1 in cancer and summarize the updates of anticancer therapy targeting SOAT1.
Identifiants
pubmed: 37409263
doi: 10.3389/fonc.2023.1197502
pmc: PMC10318190
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
1197502Informations de copyright
Copyright © 2023 Tu, Zhang and Xu.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Nat Rev Cancer. 2023 Apr;23(4):193-215
pubmed: 36717668
Proc Natl Acad Sci U S A. 2011 Apr 12;108(15):6008-13
pubmed: 21444777
J Lipid Res. 2009 Jun;50(6):1057-67
pubmed: 19189937
Cell. 2006 Jan 13;124(1):35-46
pubmed: 16413480
Biomolecules. 2021 Jun 08;11(6):
pubmed: 34201030
Int J Mol Sci. 2022 Mar 28;23(7):
pubmed: 35409086
Biomedicines. 2022 Aug 11;10(8):
pubmed: 36009491
Nat Rev Mol Cell Biol. 2020 Apr;21(4):225-245
pubmed: 31848472
J Med Chem. 1996 Dec 20;39(26):5031-4
pubmed: 8978833
Nat Med. 2000 Dec;6(12):1341-7
pubmed: 11100118
Aging (Albany NY). 2022 Mar 30;14(6):2678-2694
pubmed: 35354120
Cell. 2019 Jan 24;176(3):564-580.e19
pubmed: 30580964
Atherosclerosis. 2001 Jul;157(1):137-44
pubmed: 11427213
BMC Cancer. 2021 May 26;21(1):615
pubmed: 34039309
J Gene Med. 2023 Apr;25(4):e3475
pubmed: 36670344
Ir J Med Sci. 2022 Aug;191(4):1549-1554
pubmed: 34460058
Nat Commun. 2020 May 18;11(1):2478
pubmed: 32424158
Front Oncol. 2022 May 12;12:896433
pubmed: 35646697
Cell Metab. 2014 Mar 4;19(3):393-406
pubmed: 24606897
J Exp Med. 2020 Sep 7;217(9):
pubmed: 32633781
Nat Rev Drug Discov. 2023 Feb;22(2):127-144
pubmed: 36216888
Front Oncol. 2022 Aug 24;12:938502
pubmed: 36091156
Hepatology. 2023 May 1;77(5):1499-1511
pubmed: 35398929
Future Med Chem. 2015;7(18):2451-67
pubmed: 26669800
Biochim Biophys Acta Rev Cancer. 2020 Aug;1874(1):188394
pubmed: 32698040
Mol Cell. 2008 Sep 26;31(6):785-99
pubmed: 18922463
Cell Death Discov. 2021 Feb 26;7(1):38
pubmed: 33637695
N Engl J Med. 2006 Mar 23;354(12):1253-63
pubmed: 16554527
Nature. 2019 Mar;567(7747):257-261
pubmed: 30814741
Intern Med Rev (Wash D C). 2017 May;3(5):
pubmed: 29034362
Front Pharmacol. 2023 Mar 08;14:1130747
pubmed: 36969840
Trends Mol Med. 2021 Sep;27(9):856-867
pubmed: 34312075
Front Cell Dev Biol. 2022 May 12;10:889166
pubmed: 35646888
Am J Physiol Endocrinol Metab. 2009 Jul;297(1):E1-9
pubmed: 19141679
Clin Cancer Res. 2016 Nov 1;22(21):5337-5348
pubmed: 27281560
Oncogene. 2016 Dec 15;35(50):6378-6388
pubmed: 27132508
Cancers (Basel). 2020 Jan 19;12(1):
pubmed: 31963898
Nat Cell Biol. 2017 Jul;19(7):808-819
pubmed: 28604676
J Med Chem. 2022 Dec 22;65(24):16062-16098
pubmed: 36473091
Cell Death Discov. 2021 May 29;7(1):125
pubmed: 34052835
Curr Opin Lipidol. 2015 Apr;26(2):82-7
pubmed: 25692346
Metabolites. 2021 Aug 14;11(8):
pubmed: 34436484
Invest New Drugs. 2020 Oct;38(5):1421-1429
pubmed: 31984451
Sci Transl Med. 2020 Nov 25;12(571):
pubmed: 33239389
J Clin Invest. 2002 May;109(9):1125-31
pubmed: 11994399
Transl Gastroenterol Hepatol. 2019 May 24;4:37
pubmed: 31231704
JCI Insight. 2022 Feb 8;7(3):
pubmed: 34914638
Nat Rev Cancer. 2012 Mar 15;12(4):298-306
pubmed: 22419253
Annu Rev Biochem. 1997;66:613-38
pubmed: 9242919
Curr Opin Lipidol. 2001 Jun;12(3):289-96
pubmed: 11353332
BMC Med. 2022 Aug 9;20(1):292
pubmed: 35941608
Biochem Pharmacol. 2022 Feb;196:114731
pubmed: 34407453
J Neurosci. 2014 Oct 22;34(43):14484-501
pubmed: 25339759
Sci Transl Med. 2018 Apr 18;10(437):
pubmed: 29669855
Science. 2015 Apr 3;348(6230):74-80
pubmed: 25838376
Annu Rev Cell Dev Biol. 2006;22:129-57
pubmed: 16753029
J Immunother. 2018 Feb/Mar;41(2):45-52
pubmed: 29252915
Nature. 2016 Mar 31;531(7596):651-5
pubmed: 26982734
Prostate Cancer Prostatic Dis. 2022 Sep;25(3):484-490
pubmed: 34326474
N Engl J Med. 2006 Mar 23;354(12):1307-9
pubmed: 16554534
J Cell Biochem. 2013 Sep;114(9):2188-98
pubmed: 23564383
Int J Urol. 2008 Feb;15(2):166-70
pubmed: 18269457
Cancers (Basel). 2022 Feb 11;14(4):
pubmed: 35205638
Cancer Discov. 2011 Oct;1(5):442-56
pubmed: 22059152
Front Pharmacol. 2021 Nov 01;12:769647
pubmed: 34790132
Sci Signal. 2009 Dec 15;2(101):ra82
pubmed: 20009104
Circulation. 2004 Nov 23;110(21):3372-7
pubmed: 15533865
J Biol Chem. 1999 Dec 17;274(51):36139-45
pubmed: 10593897
Front Oncol. 2020 Sep 08;10:1788
pubmed: 33014877
J Biol Chem. 2000 Sep 8;275(36):28083-92
pubmed: 10846185