Ergosterol distribution controls surface structure formation and fungal pathogenicity.
Cryptococcus neoformans
Ysp2
ergosterol
mycology
sterol transport
virulence
Journal
mBio
ISSN: 2150-7511
Titre abrégé: mBio
Pays: United States
ID NLM: 101519231
Informations de publication
Date de publication:
31 08 2023
31 08 2023
Historique:
medline:
4
9
2023
pubmed:
6
7
2023
entrez:
6
7
2023
Statut:
ppublish
Résumé
Ergosterol, the major sterol in fungal membranes, is critical for defining membrane fluidity and regulating cellular processes. Although ergosterol synthesis has been well defined in model yeast, little is known about sterol organization in the context of fungal pathogenesis. We identified a retrograde sterol transporter, Ysp2, in the opportunistic fungal pathogen
Identifiants
pubmed: 37409809
doi: 10.1128/mbio.01353-23
pmc: PMC10470819
doi:
Substances chimiques
Ergosterol
Z30RAY509F
Fluconazole
8VZV102JFY
Antifungal Agents
0
Sterols
0
Membrane Transport Proteins
0
Fungal Proteins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0135323Subventions
Organisme : NIAID NIH HHS
ID : R21 AI136688
Pays : United States
Commentaires et corrections
Type : UpdateOf
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
Références
Mol Microbiol. 2007 Mar;63(5):1385-98
pubmed: 17244196
Biochim Biophys Acta. 2007 Jun;1771(6):769-80
pubmed: 17434796
Biochim Biophys Acta. 2000 Dec 20;1509(1-2):103-10
pubmed: 11118522
PLoS Pathog. 2018 Jan 18;14(1):e1006765
pubmed: 29346417
PLoS Pathog. 2014 May 01;10(5):e1004037
pubmed: 24789368
Eukaryot Cell. 2009 Nov;8(11):1770-9
pubmed: 19749173
Microorganisms. 2019 Sep 22;7(10):
pubmed: 31546699
mBio. 2018 Nov 6;9(6):
pubmed: 30401774
PLoS Pathog. 2017 May 22;13(5):e1006403
pubmed: 28542528
mSphere. 2022 Aug 31;7(4):e0013422
pubmed: 35758672
Proc Natl Acad Sci U S A. 2000 Mar 28;97(7):3254-9
pubmed: 10716729
Front Microbiol. 2021 Sep 10;12:727039
pubmed: 34566931
Virulence. 2012 Mar-Apr;3(2):173-81
pubmed: 22460646
FEBS Lett. 2014 Nov 3;588(21):3932-8
pubmed: 25240197
PLoS Pathog. 2015 May 13;11(5):e1004908
pubmed: 25970403
Prog Lipid Res. 2022 Apr;86:101146
pubmed: 34999137
Biochim Biophys Acta. 2006 Sep-Oct;1757(9-10):1366-70
pubmed: 16962064
Mem Inst Oswaldo Cruz. 2018;113(7):e180040
pubmed: 29742198
Curr Opin Microbiol. 2017 Dec;40:88-94
pubmed: 29154043
mBio. 2013 Jan 15;4(1):
pubmed: 23322637
mBio. 2018 Sep 18;9(5):
pubmed: 30228244
Genetics. 2022 Jan 4;220(1):
pubmed: 34791226
mBio. 2018 Jan 30;9(1):
pubmed: 29382737
J Biol Chem. 2018 Apr 13;293(15):5636-5648
pubmed: 29487131
J Cell Biol. 2020 Jun 1;219(6):
pubmed: 32320462
Antimicrob Agents Chemother. 2000 Sep;44(9):2349-55
pubmed: 10952578
Clin Microbiol Rev. 2012 Jul;25(3):387-408
pubmed: 22763631
Fungal Genet Biol. 2020 Jul;140:103368
pubmed: 32201128
PLoS Negl Trop Dis. 2017 Jun 16;11(6):e0005649
pubmed: 28622334
Clin Infect Dis. 2010 Feb 1;50(3):291-322
pubmed: 20047480
mBio. 2012 Feb 21;3(1):
pubmed: 22354955
Front Microbiol. 2015 Aug 11;6:836
pubmed: 26322039
Antimicrob Agents Chemother. 2015 Aug;59(8):4982-9
pubmed: 26055382
Mol Microbiol. 2007 May;64(3):614-29
pubmed: 17462012
Nat Chem Biol. 2014 May;10(5):400-6
pubmed: 24681535
PLoS Pathog. 2007 Feb;3(2):e22
pubmed: 17319742
Nat Rev Microbiol. 2021 Jul;19(7):454-466
pubmed: 33558691
Biochim Biophys Acta. 2016 Aug;1861(8 Pt B):928-939
pubmed: 26784528
Mol Biol Cell. 2005 Nov;16(11):5410-7
pubmed: 16135527
Lancet Infect Dis. 2022 Dec;22(12):1748-1755
pubmed: 36049486
Mol Biol Cell. 2001 Dec;12(12):4129-38
pubmed: 11739806
Proc Natl Acad Sci U S A. 2012 Feb 14;109(7):2234-9
pubmed: 22308411
mBio. 2018 Nov 20;9(6):
pubmed: 30459196
Future Microbiol. 2012 Nov;7(11):1297-313
pubmed: 23075448
mBio. 2018 Jul 24;9(4):
pubmed: 30042199
mBio. 2019 Apr 2;10(2):
pubmed: 30940711
PLoS Biol. 2013 Oct;11(10):e1001692
pubmed: 24204207
J Cell Biol. 1995 Jan;128(1-2):39-49
pubmed: 7822420
Indian J Microbiol. 2017 Sep;57(3):270-277
pubmed: 28904410
J Biol Chem. 2010 Dec 24;285(52):41051-61
pubmed: 20959444
Adv Appl Microbiol. 2009;68:133-216
pubmed: 19426855
Biochemistry. 2005 Apr 19;44(15):5816-26
pubmed: 15823040
J Fungi (Basel). 2020 Feb 24;6(1):
pubmed: 32102324
mBio. 2020 Jun 16;11(3):
pubmed: 32546619
Eukaryot Cell. 2014 May;13(5):560-71
pubmed: 24585882
mBio. 2018 Aug 21;9(4):
pubmed: 30131363
Infect Immun. 2017 Nov 17;85(12):
pubmed: 28947642
mBio. 2022 Nov 21;13(6):e0211222
pubmed: 36409123
Biochemistry (Mosc). 2019 Apr;84(4):346-357
pubmed: 31228926
Eukaryot Cell. 2007 May;6(5):755-63
pubmed: 17369440
Eukaryot Cell. 2006 Mar;5(3):488-98
pubmed: 16524904
EMBO J. 2018 Mar 15;37(6):
pubmed: 29467216
J Cell Biol. 2006 Apr 10;173(1):107-19
pubmed: 16585271
Antimicrob Agents Chemother. 2019 Jan 29;63(2):
pubmed: 30455247
J Bacteriol. 1999 Jan;181(2):444-53
pubmed: 9882657
J Biol Chem. 1989 Mar 5;264(7):3786-93
pubmed: 2917977
J Cell Biol. 2015 May 25;209(4):539-48
pubmed: 25987606
Mol Microbiol. 2003 Nov;50(4):1401-9
pubmed: 14622425
Pathogens. 2020 Oct 27;9(11):
pubmed: 33121050
J Lipid Res. 2017 Oct;58(10):2017-2036
pubmed: 28811322
PLoS Biol. 2018 May 21;16(5):e2003864
pubmed: 29782498
Elife. 2015 May 22;4:
pubmed: 26001273
Cell Microbiol. 2013 Mar;15(3):403-11
pubmed: 23127124
Genes (Basel). 2020 Jul 15;11(7):
pubmed: 32679672
mBio. 2022 Aug 30;13(4):e0153922
pubmed: 35726920