Prevalence of cognitive impairments and strengths in the early course of psychosis and depression.
Mental health
processing speed
psychosis
verbal learning
working memory
Journal
Psychological medicine
ISSN: 1469-8978
Titre abrégé: Psychol Med
Pays: England
ID NLM: 1254142
Informations de publication
Date de publication:
10 2023
10 2023
Historique:
medline:
4
10
2023
pubmed:
6
7
2023
entrez:
6
7
2023
Statut:
ppublish
Résumé
Studies investigating cognitive impairments in psychosis and depression have typically compared the average performance of the clinical group against healthy controls (HC), and do not report on the actual A comprehensive cognitive test battery comprising 12 tests was completed by 1286 individuals aged 15-41 (mean age 25.07, s.d. 5.88) from the PRONIA study at baseline: HC ( Impairment in at least two cognitive tests was as follows: ROP (88.3% moderately, 45.1% severely impaired), CHR (71.2% moderately, 22.4% severely impaired), ROD (61.6% moderately, 16.2% severely impaired). Across clinical groups, impairments were most prevalent in tests of working memory, processing speed, and verbal learning. Above average performance (>1 s.d.) in at least two tests was present for 40.5% ROD, 36.1% CHR, 16.1% ROP, and was >2 SDs in 1.8% ROD, 1.4% CHR, and 0% ROP. These findings suggest that interventions should be tailored to the individual, with working memory, processing speed, and verbal learning likely to be important transdiagnostic targets.
Sections du résumé
BACKGROUND
Studies investigating cognitive impairments in psychosis and depression have typically compared the average performance of the clinical group against healthy controls (HC), and do not report on the actual
METHODS
A comprehensive cognitive test battery comprising 12 tests was completed by 1286 individuals aged 15-41 (mean age 25.07, s.d. 5.88) from the PRONIA study at baseline: HC (
RESULTS
Impairment in at least two cognitive tests was as follows: ROP (88.3% moderately, 45.1% severely impaired), CHR (71.2% moderately, 22.4% severely impaired), ROD (61.6% moderately, 16.2% severely impaired). Across clinical groups, impairments were most prevalent in tests of working memory, processing speed, and verbal learning. Above average performance (>1 s.d.) in at least two tests was present for 40.5% ROD, 36.1% CHR, 16.1% ROP, and was >2 SDs in 1.8% ROD, 1.4% CHR, and 0% ROP.
CONCLUSIONS
These findings suggest that interventions should be tailored to the individual, with working memory, processing speed, and verbal learning likely to be important transdiagnostic targets.
Identifiants
pubmed: 37409883
doi: 10.1017/S0033291723001770
pii: S0033291723001770
pmc: PMC10520593
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
5945-5957Investigateurs
Nikolaos Koutsouleris
(N)
Dominic B Dwyer
(DB)
Lana Kambeitz-Ilankovic
(L)
Anne Ruef
(A)
Alkomiet Hasan
(A)
Claudius Hoff
(C)
Ifrah Khanyaree
(I)
Aylin Melo
(A)
Susanna Muckenhuber-Sternbauer
(S)
Yanis Köhler
(Y)
Ömer Öztürk
(Ö)
Nora Penzel
(N)
David Popovic
(D)
Adrian Rangnick
(A)
Sebastian von Saldern
(S)
Rachele Sanfelici
(R)
Moritz Spangemacher
(M)
Ana Tupac
(A)
Maria Fernanda Urquijo
(MF)
Johanna Weiske
(J)
Antonia Wosgien
(A)
Camilla Krämer
(C)
Shalaila S Haas
(SS)
Rebekka Lencer
(R)
Inga Meyhoefer
(I)
Marian Surmann
(M)
Udo Dannlowski
(U)
Olga Bienek
(O)
Georg Romer
(G)
Marlene Rosen
(M)
Theresa Lichtenstein
(T)
Stephan Ruhrmann
(S)
Joseph Kambeitz
(J)
Karsten Blume
(K)
Dominika Julkowski
(D)
Nathalie Kaden
(N)
Ruth Milz
(R)
Alexandra Nikolaides
(A)
Mauro Silke Vent
(MS)
Martina Wassen
(M)
Christos Pantelis
(C)
Stefan Borgwardt
(S)
Christina Andreou
(C)
André Schmidt
(A)
Anita Riecher-Rössler
(A)
Laura Egloff
(L)
Fabienne Harrisberger
(F)
Ulrike Heitz
(U)
Claudia Lenz
(C)
Letizia Leanza
(L)
Amatya Mackintosh
(A)
Renata Smieskova
(R)
Erich Studerus
(E)
Anna Walter
(A)
Sonja Widmayer
(S)
Alexandra Korda
(A)
Rachel Upthegrove
(R)
Chris Day
(C)
Sian Lowri Griffiths
(SL)
Mariam Iqbal
(M)
Mirabel Pelton
(M)
Pavan Mallikarjun
(P)
Alexandra Stainton
(A)
Ashleigh Lin
(A)
Paris Lalousis
(P)
Raimo K R Salokangas
(RKR)
Alexander Denissoff
(A)
Anu Ellilä
(A)
Tiina From
(T)
Markus Heinimaa
(M)
Tuula Ilonen
(T)
Päivi Jalo
(P)
Heikki Laurikainen
(H)
Antti Luutonen
(A)
Akseli Mäkela
(A)
Janina Paju
(J)
Henri Pesonen
(H)
Reetta-Liina Säilä
(RL)
Anna Toivonen
(A)
Otto Turtonen
(O)
Frauke Schultze-Lutter
(F)
Eva Meisenzahl
(E)
Sonja Botterweck
(S)
Norman Kluthausen
(N)
Gerald Antoch
(G)
Julian Caspers
(J)
Hans-Jörg Wittsack
(HJ)
Ana Beatriz Solana
(AB)
Manuela Abraham
(M)
Timo Schirmer
(T)
Alessandro Bertolino
(A)
Linda A Antonucci
(LA)
Giulio Pergola
(G)
Ileana Andriola
(I)
Barbara Gelao
(B)
Paolo Brambilla
(P)
Carlo Altamura
(C)
Marika Belleri
(M)
Francesca Bottinelli
(F)
Adele Ferro
(A)
Marta Re
(M)
Emiliano Monzani
(E)
Maurizio Sberna
(M)
Armando D'Agostino
(A)
Lorenzo Del Fabro
(L)
Giampaolo Perna
(G)
Maria Nobile
(M)
Alessandra Alciati
(A)
Matteo Balestrieri
(M)
Carolina Bonivento
(C)
Giuseppe Cabras
(G)
Franco Fabbro
(F)
Marco Garzitto
(M)
Sara Piccin
(S)
Commentaires et corrections
Type : CommentIn
Type : CommentIn
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