Disc Test for Detecting Staphylococcus aureus Strains Producing Type A and Type C β-Lactamases.
Staphylococcus aureus
cefazolin inoculum effect
disc test
Journal
Microbiology spectrum
ISSN: 2165-0497
Titre abrégé: Microbiol Spectr
Pays: United States
ID NLM: 101634614
Informations de publication
Date de publication:
17 08 2023
17 08 2023
Historique:
medline:
21
8
2023
pubmed:
6
7
2023
entrez:
6
7
2023
Statut:
ppublish
Résumé
Staphylococcus aureus can produce β-lactamases capable of hydrolyzing penicillins and first-generation cephalosporins. The propensity of type A and type C β-lactamase-producing S. aureus (TAPSA and TCPSA) to hydrolyze cefazolin at a high inoculum is termed the cefazolin inoculum effect (CIE). Strains with a CIE have a theoretical risk of causing treatment failure and are unable to be detected routinely by most laboratories. We developed a high-performing yet straightforward β-lactamase disc test that identifies and differentiates both TAPSA and TCPSA and is suitable for routine diagnostic laboratory workflows. Clinical isolates of S. aureus resistant to penicillin were identified, and their
Identifiants
pubmed: 37409947
doi: 10.1128/spectrum.00220-23
pmc: PMC10434206
doi:
Substances chimiques
Cefazolin
IHS69L0Y4T
beta-Lactamases
EC 3.5.2.6
Cephalothin
R72LW146E6
Anti-Bacterial Agents
0
Oxacillin
UH95VD7V76
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0022023Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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