New halimane and clerodane diterpenoids from Croton cnidophyllus.
Anti-inflammatory activity
Croton cnidophyllus
Euphorbiaceae
Furanoditerpenoids
Journal
Natural products and bioprospecting
ISSN: 2192-2195
Titre abrégé: Nat Prod Bioprospect
Pays: Germany
ID NLM: 101577734
Informations de publication
Date de publication:
06 Jul 2023
06 Jul 2023
Historique:
received:
09
05
2023
accepted:
28
06
2023
medline:
6
7
2023
pubmed:
6
7
2023
entrez:
6
7
2023
Statut:
epublish
Résumé
Three new halimane furanoditerpenoids (1-3) and three new clerodane furanoditerpenoids (4-6), along with seven known terpenoids including four pimarane diterpenoids (7-10) and three norisoprenoids (11-13) were isolated from the 95% EtOH extracts of the plants of Croton cnidophyllus. The 2D structures including absolute configuration of new furanoditerpenoids (1-6) were elucidated by analysis of their HRMS and NMR data as well as comparison of experimental and calculated ECD curves. Bioassay revealed that two compounds (8 and 9) possessed certain inhibitory effects against NO production stimulated by LPS, with IC
Identifiants
pubmed: 37410272
doi: 10.1007/s13659-023-00386-z
pii: 10.1007/s13659-023-00386-z
pmc: PMC10326188
doi:
Types de publication
Journal Article
Langues
eng
Pagination
21Subventions
Organisme : National Natural Science Foundation of China
ID : 82273804
Organisme : Science and Technology Program of Guangzhou, China
ID : 202201011613
Organisme : Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai)
ID : SML2021SP301
Organisme : Open Program of Shenzhen Bay Laboratory
ID : SZBL2021080601007
Organisme : Local Innovative and Research Teams Project of Guangdong Pearl River Talents Program
ID : 2017BT01Y093
Organisme : Guangdong Basic and Applied Basic Research Foundation, China
ID : 2021B1515140062
Informations de copyright
© 2023. The Author(s).
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