Race, cortisol, and subclinical cardiovascular disease in 9- to 11-year-old children.
Journal
Health psychology : official journal of the Division of Health Psychology, American Psychological Association
ISSN: 1930-7810
Titre abrégé: Health Psychol
Pays: United States
ID NLM: 8211523
Informations de publication
Date de publication:
Sep 2023
Sep 2023
Historique:
pmc-release:
01
09
2024
medline:
18
8
2023
pubmed:
6
7
2023
entrez:
6
7
2023
Statut:
ppublish
Résumé
Non-Hispanic Black Americans have a greater risk for certain subtypes of cardiovascular disease (CVD; e.g., stroke and heart failure) relative to non-Hispanic White Americans. Moreover, Black relative to White adults consistently show elevated cortisol, a CVD risk. The impact of race, environmental stress, and cortisol on subclinical CVD has yet to be fully researched in children. We assessed diurnal salivary cortisol slopes and hair cortisol in a sample of 9- to 11-year-old children ( After adjusting for covariates, we found that Black children had significantly flatter diurnal cortisol slopes, higher hair cortisol, and thicker IMT than White children. Significant pathways were found: race → salivary cortisol slope → cfPWV (effect = -0.059, 95% CI [-0.116, -0.002]) and race → hair cortisol → cIMT (effect = -0.008, [-0.016, -0.002]). Black children also experienced significantly more environmental stress than White children; however, only income inequality served as a significant indirect pathway from race to salivary cortisol (effect = 0.029, [0.003, 0.060]). Relative to White children, Black children had significantly greater hair cortisol and flatter diurnal slopes which, in turn, were associated with greater subclinical CVD. As suggested by a significant indirect pathway, income inequality might partially explain the race-cortisol association. (PsycInfo Database Record (c) 2023 APA, all rights reserved).
Sections du résumé
BACKGROUND
BACKGROUND
Non-Hispanic Black Americans have a greater risk for certain subtypes of cardiovascular disease (CVD; e.g., stroke and heart failure) relative to non-Hispanic White Americans. Moreover, Black relative to White adults consistently show elevated cortisol, a CVD risk. The impact of race, environmental stress, and cortisol on subclinical CVD has yet to be fully researched in children.
METHOD
METHODS
We assessed diurnal salivary cortisol slopes and hair cortisol in a sample of 9- to 11-year-old children (
RESULTS
RESULTS
After adjusting for covariates, we found that Black children had significantly flatter diurnal cortisol slopes, higher hair cortisol, and thicker IMT than White children. Significant pathways were found: race → salivary cortisol slope → cfPWV (effect = -0.059, 95% CI [-0.116, -0.002]) and race → hair cortisol → cIMT (effect = -0.008, [-0.016, -0.002]). Black children also experienced significantly more environmental stress than White children; however, only income inequality served as a significant indirect pathway from race to salivary cortisol (effect = 0.029, [0.003, 0.060]).
CONCLUSIONS
CONCLUSIONS
Relative to White children, Black children had significantly greater hair cortisol and flatter diurnal slopes which, in turn, were associated with greater subclinical CVD. As suggested by a significant indirect pathway, income inequality might partially explain the race-cortisol association. (PsycInfo Database Record (c) 2023 APA, all rights reserved).
Identifiants
pubmed: 37410422
pii: 2023-87659-001
doi: 10.1037/hea0001300
pmc: PMC10601363
mid: NIHMS1917472
doi:
Substances chimiques
Hydrocortisone
WI4X0X7BPJ
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
657-667Subventions
Organisme : NIEHS NIH HHS
ID : R01 ES023252
Pays : United States
Organisme : NIH HHS
Pays : United States
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