Siglecs as potential targets of therapy in human mast cell- and/or eosinophil-associated diseases.
Allergy
CD22
CD33
Eosinophils
IgE
Mast cells
Siglec-6
Siglec-8
Journal
Seminars in immunology
ISSN: 1096-3618
Titre abrégé: Semin Immunol
Pays: England
ID NLM: 9009458
Informations de publication
Date de publication:
09 2023
09 2023
Historique:
pmc-release:
01
09
2024
medline:
21
8
2023
pubmed:
7
7
2023
entrez:
6
7
2023
Statut:
ppublish
Résumé
Siglecs (sialic acid-binding immunoglobulin-like lectins) are a family of vertebrate glycan-binding cell-surface proteins. The majority mediate cellular inhibitory activity once engaged by specific ligands or ligand-mimicking molecules. As a result, Siglec engagement is now of interest as a strategy to therapeutically dampen unwanted cellular responses. When considering allergic inflammation, human eosinophils and mast cells express overlapping but distinct patterns of Siglecs. For example, Siglec-6 is selectively and prominently expressed on mast cells while Siglec-8 is highly specific for both eosinophils and mast cells. This review will focus on a subset of Siglecs and their various endogenous or synthetic sialoside ligands that regulate eosinophil and mast cell function and survival. It will also summarize how certain Siglecs have become the focus of novel therapies for allergic and other eosinophil- and mast cell-related diseases.
Identifiants
pubmed: 37413923
pii: S1044-5323(23)00090-8
doi: 10.1016/j.smim.2023.101799
pmc: PMC10528103
mid: NIHMS1910388
pii:
doi:
Substances chimiques
Sialic Acid Binding Immunoglobulin-like Lectins
0
Antigens, CD
0
Ligands
0
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
101799Subventions
Organisme : NIAID NIH HHS
ID : R01 AI137174
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI136443
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI070535
Pays : United States
Organisme : NHLBI NIH HHS
ID : P01 HL107151
Pays : United States
Organisme : NIAID NIH HHS
ID : R21 AI159586
Pays : United States
Organisme : NIAID NIH HHS
ID : P01 AI145818
Pays : United States
Informations de copyright
Copyright © 2023 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Conflict of interest statement J.A.O. has nothing to disclose. B.A.Y. is a current employee of, and owns stock and stock options from, Allakos, Inc. R.P.S. received consulting fees from Intersect ENT, Merck, GlaxoSmithKline, Sanofi, AstraZeneca, Medimmune, Genentech, Actobio Therapeutics, Lyra Therapeutics, Astellas Pharma, Allakos and Otsuka. He also receives royalties from Siglec-8 and Siglec-8 ligand related patents licensed by Johns Hopkins University to Allakos, Inc. and owns stock in Allakos. B.S.B. receives remuneration for serving on the scientific advisory board of Allakos, Inc. and owns stock in Allakos. He receives consulting fees from Third Harmonic Bio, Lupagen, Sanofi, and Acelyrin. He receives publication-related royalty payments from Elsevier and UpToDate. He is a co-inventor on existing Siglec-8–related patents and thus may be entitled to a share of royalties received by Johns Hopkins University during development and potential sales of such products. B.S.B. is also a co-founder of Allakos, Inc. which makes him subject to certain restrictions under university policy. The terms of this arrangement are being managed by Johns Hopkins University and Northwestern University in accordance with their conflict-of-interest policies.
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