The Eph/Ephrin system in primary bone tumor and bone cancer pain.
Eph/Ephrin
primary bone tumor
Journal
Aging
ISSN: 1945-4589
Titre abrégé: Aging (Albany NY)
Pays: United States
ID NLM: 101508617
Informations de publication
Date de publication:
06 07 2023
06 07 2023
Historique:
received:
14
04
2023
accepted:
19
06
2023
medline:
7
8
2023
pubmed:
7
7
2023
entrez:
6
7
2023
Statut:
ppublish
Résumé
The family of Eph receptor tyrosine kinases and their Ephrin ligands system constitutes a bidirectional signaling pathway. Eph/Ephrin system coordinate a wide spectrum of pathologic processes during development, metastasis, prognosis, drug resistance and angiogenesis in carcinogenesis. Chemotherapy, surgery and radiotherapy are the most commonly used clinical treatments for primary bone tumors. Therefore, surgical resection is often unable to completely eliminate the tumor, and this is the main cause of metastasis and postoperative recurrence. A growing body of literature has been published lately revitalizing our scientific interest towards the role of Eph/Ephrins in pathogenesis and the treatment of bone tumor and bone cancer pain. This study mainly reviewed the roles of Eph/Ephrin system that has both tumor-suppressing and -promoting roles in primary bone tumors and bone cancer pain. Understanding the intracellular mechanisms of Eph/Ephrin system in tumorigenesis and metastasis of bone tumors might provide a foundation for the development of Eph/Ephrin targeted anti-cancer therapy.
Identifiants
pubmed: 37413995
pii: 204852
doi: 10.18632/aging.204852
pmc: PMC10415561
doi:
Substances chimiques
Ephrins
0
Receptors, Eph Family
EC 2.7.10.1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
7324-7332Références
Cell Metab. 2006 Aug;4(2):111-21
pubmed: 16890539
Cell Oncol (Dordr). 2017 Oct;40(5):483-496
pubmed: 28721629
Cancer Gene Ther. 2021 Apr;28(3-4):321-334
pubmed: 32873870
JCI Insight. 2019 Dec 5;4(23):
pubmed: 31661464
Cells. 2021 Oct 26;10(11):
pubmed: 34831119
Nat Rev Cancer. 2010 Mar;10(3):165-80
pubmed: 20179713
Pain. 2013 Dec;154(12):2823-2835
pubmed: 23973554
Cancers (Basel). 2023 Feb 02;15(3):
pubmed: 36765919
Int J Mol Sci. 2022 May 05;23(9):
pubmed: 35563562
Histopathology. 2014 Mar;64(4):461-76
pubmed: 24428620
Blood. 2009 Aug 27;114(9):1803-12
pubmed: 19597185
Cancers (Basel). 2020 Jun 10;12(6):
pubmed: 32531992
Medicine (Baltimore). 2021 Jan 29;100(4):e23447
pubmed: 33530159
Curr Opin Cell Biol. 2010 Oct;22(5):611-6
pubmed: 20810264
Cancer Res. 2005 Dec 15;65(24):11520-8
pubmed: 16357161
Cell Mol Life Sci. 2018 Nov;75(22):4207-4222
pubmed: 29938386
Sci Adv. 2021 Jul 2;7(27):
pubmed: 34215585
Neurosci Lett. 2011 Jun 8;496(3):163-7
pubmed: 21514363
Mol Cancer Res. 2007 Mar;5(3):283-93
pubmed: 17374733
Pharm Res. 2017 Dec;34(12):2891-2900
pubmed: 29110283
Clin Lymphoma Myeloma Leuk. 2011 Feb;11(1):50-3
pubmed: 21454190
Biochem Biophys Res Commun. 2018 Sep 18;503(4):2212-2217
pubmed: 29953858
PLoS One. 2013 Aug 12;8(8):e71449
pubmed: 23951165
Cancer. 2002 Aug 15;95(4):862-9
pubmed: 12209731
Br J Cancer. 2013 Oct 15;109(8):2142-54
pubmed: 24064975
Cancers (Basel). 2022 Dec 30;15(1):
pubmed: 36612267
Cell Rep. 2022 Jul 5;40(1):111031
pubmed: 35793621
Cancer Res. 2011 Jul 1;71(13):4392-402
pubmed: 21555368
APMIS. 2009 Apr;117(4):277-85
pubmed: 19338516
Tumour Biol. 2017 Mar;39(3):1010428317694298
pubmed: 28351297
Indian J Cancer. 2010 Jan-Mar;47(1):46-52
pubmed: 20071790
Histol Histopathol. 2008 Aug;23(8):1011-23
pubmed: 18498077
Int J Cancer. 2018 Sep 1;143(5):1188-1201
pubmed: 29582409
Nat Rev Mol Cell Biol. 2005 Jun;6(6):462-75
pubmed: 15928710
J Cell Sci. 2007 Jul 1;120(Pt 13):2179-89
pubmed: 17567680
Blood. 2005 Nov 1;106(9):3160-5
pubmed: 16030194
PLoS One. 2017 Jun 12;12(6):e0175553
pubmed: 28604772
Oncogene. 2017 Oct 5;36(40):5620-5630
pubmed: 28581527
Exp Mol Med. 2018 Apr 27;50(4):1-18
pubmed: 29700355
Neurol Res. 2021 Jul;43(7):528-534
pubmed: 33541257
Science. 1987 Dec 18;238(4834):1717-20
pubmed: 2825356
Cell Death Dis. 2018 Nov 19;9(12):1146
pubmed: 30451837
Int J Mol Sci. 2019 Nov 30;20(23):
pubmed: 31801267
Proc Natl Acad Sci U S A. 2008 Aug 26;105(34):12307-12
pubmed: 18715996
Histopathology. 2010 Dec;57(6):836-50
pubmed: 21166698
Bone. 2017 Aug;101:10-20
pubmed: 28414140
Int J Mol Med. 2016 Mar;37(3):565-74
pubmed: 26782642
Int J Mol Sci. 2021 Aug 05;22(16):
pubmed: 34445116
Int J Dermatol. 2016 Jan;55(1):3-10
pubmed: 26498559
Biomed Res Int. 2018 Feb 28;2018:7390104
pubmed: 29682554
Hum Pathol. 2009 Dec;40(12):1679-85
pubmed: 19695673
Cell. 2008 Apr 4;133(1):38-52
pubmed: 18394988
Braz J Med Biol Res. 2021 Jan 08;54(2):e9161
pubmed: 33439936