Differential roles of FOXC2 in the trabecular meshwork and Schlemm's canal in glaucomatous pathology.

Animals Mice Aqueous Humor / physiology Glaucoma / genetics Intraocular Pressure Schlemm's Canal Trabecular Meshwork / pathology

Journal

Life science alliance
ISSN: 2575-1077
Titre abrégé: Life Sci Alliance
Pays: United States
ID NLM: 101728869

Informations de publication

Date de publication:
Sep 2023
Historique:
received: 12 09 2022
revised: 28 06 2023
accepted: 29 06 2023
medline: 10 7 2023
pubmed: 7 7 2023
entrez: 6 7 2023
Statut: epublish

Résumé

Impaired development and maintenance of Schlemm's canal (SC) are associated with perturbed aqueous humor outflow and intraocular pressure. The angiopoietin (ANGPT)/TIE2 signaling pathway regulates SC development and maintenance, whereas the molecular mechanisms of crosstalk between SC and the neural crest (NC)-derived neighboring tissue, the trabecular meshwork (TM), are poorly understood. Here, we show NC-specific forkhead box (

Identifiants

DOI: 10.26508/lsa.202201721 PMID: 37414529 PMC: PMC10326420
pubmed: 37414529
pii: 6/9/e202201721
doi: 10.26508/lsa.202201721
pmc: PMC10326420
pii:
doi:

Substances chimiques

mesenchyme fork head 1 protein 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : NEI NIH HHS
ID : R01 EY026078
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL144129
Pays : United States
Organisme : NEI NIH HHS
ID : R01 EY030124
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA060553
Pays : United States
Organisme : NEI NIH HHS
ID : R01 EY028304
Pays : United States
Organisme : NHLBI NIH HHS
ID : T32 HL094293
Pays : United States
Organisme : NEI NIH HHS
ID : R01 EY034740
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM142604
Pays : United States
Organisme : NEI NIH HHS
ID : R01 EY029121
Pays : United States
Organisme : NEI NIH HHS
ID : U01 EY033001
Pays : United States
Organisme : NEI NIH HHS
ID : R01 EY031710
Pays : United States

Informations de copyright

© 2023 Ujiie et al.

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Auteurs

Naoto Ujiie (N)

Feinberg Cardiovascular and Renal Research Institute, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
ORCID: 0000-0001-9431-0912

Pieter R Norden (PR)

Feinberg Cardiovascular and Renal Research Institute, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.

Raymond Fang (R)

Department of Biomedical Engineering, Northwestern University, Evanston, IL, USA.

Lisa Beckmann (L)

Department of Biomedical Engineering, Northwestern University, Evanston, IL, USA.

Zhen Cai (Z)

Department of Biomedical Engineering, Northwestern University, Evanston, IL, USA.

Junghun Kweon (J)

Department of Biomedical Engineering, Northwestern University, Evanston, IL, USA.

Ting Liu (T)

Feinberg Cardiovascular and Renal Research Institute, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.

Can Tan (C)

Feinberg Cardiovascular and Renal Research Institute, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
ORCID: 0000-0002-1450-8396

Megan S Kuhn (MS)

Duke Eye Center, Duke University, Durham, NC, USA.

W Daniel Stamer (WD)

Duke Eye Center, Duke University, Durham, NC, USA.

Kazushi Aoto (K)

Department of Biochemistry, Hamamatsu University School of Medicine, Hamamatsu, Japan.
ORCID: 0000-0002-0304-9622

Susan E Quaggin (SE)

Feinberg Cardiovascular and Renal Research Institute, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Division of Nephrology and Hypertension, Northwestern University Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.

Hao F Zhang (HF)

Department of Biomedical Engineering, Northwestern University, Evanston, IL, USA.
Department of Ophthalmology, Northwestern University, Chicago, IL, USA.

Tsutomu Kume (T)

Feinberg Cardiovascular and Renal Research Institute, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA t-kume@northwestern.edu.
Department of Ophthalmology, Northwestern University, Chicago, IL, USA.
ORCID: 0000-0002-6005-5316

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Differential roles of FOXC2 in the trabecular...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Differential roles of FOXC2 in the trabecular...
questionsmedicales.fr › Liquides et sécrétions biologiques › Liquides biologiques › Liquide extracellulaire › Humeur aqueuse › Differential roles of FOXC2 in the trabecular...
questionsmedicales.fr › Maladies de l'oeil › Hypertension oculaire › Glaucome › Differential roles of FOXC2 in the trabecular...
questionsmedicales.fr › Phénomènes physiologiques oculaires › Pression intraoculaire › Differential roles of FOXC2 in the trabecular...
questionsmedicales.fr › Organes des sens › Oeil › Pôle antérieur du bulbe oculaire › Cornée › Limbe de la cornée › Sinus veineux de la sclère › Differential roles of FOXC2 in the trabecular...
questionsmedicales.fr › Organes des sens › Oeil › Pôle antérieur du bulbe oculaire › Réseau trabéculaire de la sclère › Differential roles of FOXC2 in the trabecular...