Incidence and Long-term Functional Outcome of Neurologic Disorders in Hospitalized Patients With COVID-19 Infected With Pre-Omicron Variants.
Journal
Neurology
ISSN: 1526-632X
Titre abrégé: Neurology
Pays: United States
ID NLM: 0401060
Informations de publication
Date de publication:
29 08 2023
29 08 2023
Historique:
received:
06
11
2022
accepted:
04
05
2023
medline:
31
8
2023
pubmed:
7
7
2023
entrez:
6
7
2023
Statut:
ppublish
Résumé
A variety of neurologic disorders have been reported as presentations or complications of coronavirus disease 2019 (COVID-19) infection. The objective of this study was to determine their incidence dynamics and long-term functional outcome. The Neuro-COVID Italy study was a multicenter, observational, cohort study with ambispective recruitment and prospective follow-up. Consecutive hospitalized patients presenting new neurologic disorders associated with COVID-19 infection (neuro-COVID), independently from respiratory severity, were systematically screened and actively recruited by neurology specialists in 38 centers in Italy and the Republic of San Marino. The primary outcomes were incidence of neuro-COVID cases during the first 70 weeks of the pandemic (March 2020-June 2021) and long-term functional outcome at 6 months, categorized as full recovery, mild symptoms, disabling symptoms, or death. Among 52,759 hospitalized patients with COVID-19, 1,865 patients presenting 2,881 new neurologic disorders associated with COVID-19 infection (neuro-COVID) were recruited. The incidence of neuro-COVID cases significantly declined over time, comparing the first 3 pandemic waves (8.4%, 95% CI 7.9-8.9; 5.0%, 95% CI 4.7-5.3; 3.3%, 95% CI 3.0-3.6, respectively; Incidence of COVID-associated neurologic disorders decreased during the prevaccination phase of the pandemic. Long-term functional outcome was favorable in most neuro-COVID disorders, although mild symptoms commonly lasted more than 6 months after infection.
Sections du résumé
BACKGROUND AND OBJECTIVES
A variety of neurologic disorders have been reported as presentations or complications of coronavirus disease 2019 (COVID-19) infection. The objective of this study was to determine their incidence dynamics and long-term functional outcome.
METHODS
The Neuro-COVID Italy study was a multicenter, observational, cohort study with ambispective recruitment and prospective follow-up. Consecutive hospitalized patients presenting new neurologic disorders associated with COVID-19 infection (neuro-COVID), independently from respiratory severity, were systematically screened and actively recruited by neurology specialists in 38 centers in Italy and the Republic of San Marino. The primary outcomes were incidence of neuro-COVID cases during the first 70 weeks of the pandemic (March 2020-June 2021) and long-term functional outcome at 6 months, categorized as full recovery, mild symptoms, disabling symptoms, or death.
RESULTS
Among 52,759 hospitalized patients with COVID-19, 1,865 patients presenting 2,881 new neurologic disorders associated with COVID-19 infection (neuro-COVID) were recruited. The incidence of neuro-COVID cases significantly declined over time, comparing the first 3 pandemic waves (8.4%, 95% CI 7.9-8.9; 5.0%, 95% CI 4.7-5.3; 3.3%, 95% CI 3.0-3.6, respectively;
DISCUSSION
Incidence of COVID-associated neurologic disorders decreased during the prevaccination phase of the pandemic. Long-term functional outcome was favorable in most neuro-COVID disorders, although mild symptoms commonly lasted more than 6 months after infection.
Identifiants
pubmed: 37414564
pii: WNL.0000000000207534
doi: 10.1212/WNL.0000000000207534
pmc: PMC10501088
doi:
Types de publication
Multicenter Study
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e892-e903Investigateurs
Andrea Pilotto
(A)
Stefano Cotti Piccinelli
(SC)
Susanna Lazzari
(S)
Giulia Negro
(G)
Giulia Sofia Cereda
(GS)
Roberto Infante
(R)
Ginevra Giovannelli
(G)
Claudia Cutellè
(C)
Lorenzo Tinti
(L)
Susanna Diamanti
(S)
Gaia Fanella
(G)
Nicola Rifino
(N)
Lucio Tremolizzo
(L)
Giovanni Ermanis
(G)
Fedra Kuris
(F)
Roberto Sartor
(R)
Francesco Bax
(F)
Gian Luigi Gigli
(GL)
Edoardo Barvas
(E)
Mirco Volpini
(M)
Roberto Frusciante
(R)
Mariaeva Bernardi
(M)
Marinella Turla
(M)
Raffaella Valenti
(R)
Emanuele Bartolini
(E)
Lorenzo Kiferle
(L)
Silvia Pradella
(S)
Alessandro Innocenti
(A)
Ludovico Ciolli
(L)
Niccolò Orlandi
(N)
Gabriele Vandelli
(G)
Marco Mazzoli
(M)
Luana Benedetti
(L)
Matteo Pardini
(M)
Stefano Grisanti
(S)
Erica Biassoni
(E)
Corrado Cabona
(C)
Angelo Schenone
(A)
Federica Boso
(F)
Federica Agosta
(F)
Mario Orrico
(M)
Luisa Roveri
(L)
Giacomo Sferruzza
(G)
Mauro Gentile
(M)
Laura Piccolo
(L)
Elena Merli
(E)
Andrea Salmaggi
(A)
Tommaso Bocci
(T)
Roberta Ferrucci
(R)
Michelangelo Dini
(M)
Maria Guarino
(M)
Marianna Nicodemo
(M)
Sandro Beretta
(S)
Alessia Giossi
(A)
Chiara Campana
(C)
Bruno Censori
(B)
Guido Primiano
(G)
Maria Troiano
(M)
Luca Bollo
(L)
Narghes Calcagno
(N)
Francesca Trogu
(F)
Claudia Morelli
(C)
Carlo Colosimo
(C)
Chiara Di Schino
(C)
Franco Costantini
(F)
Giuseppe Cosentino
(G)
Enrico Marchioni
(E)
Federica Avorio
(F)
Giovanna Russelli
(G)
Giovanna Panarello
(G)
Giovanna Carlucci
(G)
Federica Azzolini
(F)
Antonio Lotti
(A)
Alfonso Ciccone
(A)
Giovanni Furlanis
(G)
Bruno Giometto
(B)
Giulia Bellavita
(G)
Scarano Valentina
(S)
Lorenzo Lorusso
(L)
Maria Concetta Altavista
(MC)
Amelia Brigandì
(A)
Chiara Sorbera
(C)
Lucia Gatto
(L)
Simona Sacco
(S)
Raffaella Clerici
(R)
Erika Schirinzi
(E)
Enrica Bonanni
(E)
Elena Merico
(E)
Natascia Beretta
(N)
Giuseppe Gallo
(G)
Chiara Sciolla
(C)
Antonio Bertolotto
(A)
Simone Pomati
(S)
Federico Masserini
(F)
Federico Camilli
(F)
Ivan Panzera
(I)
Patrizio Cardinali
(P)
Maria Cristina Acciarri
(M)
Giovanna De Michele
(G)
Sandra Perillo
(S)
Gianluigi Rosalio Palmieri
(GR)
Nunzia Cuomo
(N)
Augusta Giglio
(A)
Informations de copyright
Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology.
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