Effects of Corsi-Rosenthal boxes on indoor air contaminants: non-targeted analysis using high resolution mass spectrometry.
Air quality
Corsi-Rosenthal (CR) boxes
Exposome
High resolution mass spectrometry
Interventions
Non-targeted analysis (NTA)
Journal
Journal of exposure science & environmental epidemiology
ISSN: 1559-064X
Titre abrégé: J Expo Sci Environ Epidemiol
Pays: United States
ID NLM: 101262796
Informations de publication
Date de publication:
07 2023
07 2023
Historique:
received:
23
12
2022
accepted:
16
06
2023
revised:
15
06
2023
medline:
7
8
2023
pubmed:
7
7
2023
entrez:
6
7
2023
Statut:
ppublish
Résumé
In response to COVID-19, attention was drawn to indoor air quality and interventions to mitigate airborne COVID-19 transmission. Of developed interventions, Corsi-Rosenthal (CR) boxes, a do-it-yourself indoor air filter, may have potential co-benefits of reducing indoor air contaminant levels. We employed non-targeted and suspect screening analysis (NTA and SSA) to detect and identify volatile and semi-volatile organic contaminants (VOCs and SVOCs) that decreased in indoor air following installation of CR boxes. Using a natural experiment, we sampled indoor air before and during installation of CR boxes in 17 rooms inside an occupied office building. We measured VOCs and SVOCs using gas chromatography (GC) high resolution mass spectrometry (HRMS) with electron ionization (EI) and liquid chromatography (LC) HRMS in negative and positive electrospray ionization (ESI). We examined area count changes during vs. before operation of the CR boxes using linear mixed models. Transformed (log2) area counts of 71 features significantly decreased by 50-100% after CR boxes were installed (False Discovery Rate (FDR) p-value < 0.2). Of the significantly decreased features, four chemicals were identified with Level 1 confidence, 45 were putatively identified with Level 2-4 confidence, and 22 could not be identified (Level 5). Identified and putatively identified features (Level ≥4) that declined included disinfectants (n = 1), fragrance and/or food chemicals (n = 9), nitrogen-containing heterocyclic compounds (n = 4), organophosphate esters (n = 1), polycyclic aromatic hydrocarbons (n = 8), polychlorinated biphenyls (n = 1), pesticides/herbicides/insecticides (n = 18), per- and polyfluorinated alkyl substances (n = 2), phthalates (n = 3), and plasticizers (n = 2). We used SSA and NTA to demonstrate that do-it-yourself Corsi-Rosenthal boxes are an effective means for improving indoor air quality by reducing a wide range of volatile and semi-volatile organic contaminants.
Sections du résumé
BACKGROUND
In response to COVID-19, attention was drawn to indoor air quality and interventions to mitigate airborne COVID-19 transmission. Of developed interventions, Corsi-Rosenthal (CR) boxes, a do-it-yourself indoor air filter, may have potential co-benefits of reducing indoor air contaminant levels.
OBJECTIVE
We employed non-targeted and suspect screening analysis (NTA and SSA) to detect and identify volatile and semi-volatile organic contaminants (VOCs and SVOCs) that decreased in indoor air following installation of CR boxes.
METHODS
Using a natural experiment, we sampled indoor air before and during installation of CR boxes in 17 rooms inside an occupied office building. We measured VOCs and SVOCs using gas chromatography (GC) high resolution mass spectrometry (HRMS) with electron ionization (EI) and liquid chromatography (LC) HRMS in negative and positive electrospray ionization (ESI). We examined area count changes during vs. before operation of the CR boxes using linear mixed models.
RESULTS
Transformed (log2) area counts of 71 features significantly decreased by 50-100% after CR boxes were installed (False Discovery Rate (FDR) p-value < 0.2). Of the significantly decreased features, four chemicals were identified with Level 1 confidence, 45 were putatively identified with Level 2-4 confidence, and 22 could not be identified (Level 5). Identified and putatively identified features (Level ≥4) that declined included disinfectants (n = 1), fragrance and/or food chemicals (n = 9), nitrogen-containing heterocyclic compounds (n = 4), organophosphate esters (n = 1), polycyclic aromatic hydrocarbons (n = 8), polychlorinated biphenyls (n = 1), pesticides/herbicides/insecticides (n = 18), per- and polyfluorinated alkyl substances (n = 2), phthalates (n = 3), and plasticizers (n = 2).
IMPACT STATEMENT
We used SSA and NTA to demonstrate that do-it-yourself Corsi-Rosenthal boxes are an effective means for improving indoor air quality by reducing a wide range of volatile and semi-volatile organic contaminants.
Identifiants
pubmed: 37414869
doi: 10.1038/s41370-023-00577-3
pii: 10.1038/s41370-023-00577-3
doi:
Substances chimiques
Volatile Organic Compounds
0
Polycyclic Aromatic Hydrocarbons
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
537-547Subventions
Organisme : NIEHS NIH HHS
ID : R21 ES034187
Pays : United States
Informations de copyright
© 2023. The Author(s), under exclusive licence to Springer Nature America, Inc.
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