Interstitial-fluid shear stresses induced by vertically oscillating head motion lower blood pressure in hypertensive rats and humans.
Journal
Nature biomedical engineering
ISSN: 2157-846X
Titre abrégé: Nat Biomed Eng
Pays: England
ID NLM: 101696896
Informations de publication
Date de publication:
Nov 2023
Nov 2023
Historique:
received:
10
06
2020
accepted:
27
05
2023
medline:
17
11
2023
pubmed:
7
7
2023
entrez:
6
7
2023
Statut:
ppublish
Résumé
The mechanisms by which physical exercise benefits brain functions are not fully understood. Here, we show that vertically oscillating head motions mimicking mechanical accelerations experienced during fast walking, light jogging or treadmill running at a moderate velocity reduce the blood pressure of rats and human adults with hypertension. In hypertensive rats, shear stresses of less than 1 Pa resulting from interstitial-fluid flow induced by such passive head motions reduced the expression of the angiotensin II type-1 receptor in astrocytes in the rostral ventrolateral medulla, and the resulting antihypertensive effects were abrogated by hydrogel introduction that inhibited interstitial-fluid movement in the medulla. Our findings suggest that oscillatory mechanical interventions could be used to elicit antihypertensive effects.
Identifiants
pubmed: 37414976
doi: 10.1038/s41551-023-01061-x
pii: 10.1038/s41551-023-01061-x
pmc: PMC10651490
doi:
Substances chimiques
Antihypertensive Agents
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1350-1373Subventions
Organisme : MEXT | Japan Society for the Promotion of Science (JSPS)
ID : 20K19367
Organisme : MEXT | Japan Society for the Promotion of Science (JSPS)
ID : 21H03792, 21K19893
Organisme : MEXT | Japan Society for the Promotion of Science (JSPS)
ID : 19K06899, 22K06454
Organisme : MEXT | Japan Society for the Promotion of Science (JSPS)
ID : Brain/MINDS, JP20dm0207057, JP21dm0207111
Organisme : MEXT | Japan Society for the Promotion of Science (JSPS)
ID : 17H02127, 18H03138
Organisme : MEXT | Japan Society for the Promotion of Science (JSPS)
ID : 15H01820, 15H04966, 18H04088, 20K21778, 21H04866
Organisme : Japan Agency for Medical Research and Development (AMED)
ID : 21dk0310116j0201
Organisme : MEXT | Japan Science and Technology Agency (JST)
ID : MIRAI Program
Commentaires et corrections
Type : ErratumIn
Informations de copyright
© 2023. The Author(s).
Références
Brain Res Bull. 2011 Mar 10;84(4-5):267-79
pubmed: 21087657
J Intern Med. 2008 Sep;264(3):224-36
pubmed: 18793332
Hypertension. 1991 Nov;18(5 Suppl):III49-53
pubmed: 1937686
Hypertension. 2009 Dec;54(6):1393-400
pubmed: 19841289
J Biomech. 2007;40(7):1484-92
pubmed: 16987520
Circulation. 2004 May 18;109(19):2357-62
pubmed: 15117836
Biomed Res. 2015;36(3):169-77
pubmed: 26106046
Development. 1992 Sep;116(1):201-11
pubmed: 1483388
Sci Rep. 2015 Dec 03;5:17673
pubmed: 26631412
Biophys J. 2015 Oct 20;109(8):1565-73
pubmed: 26488647
FASEB J. 1993 May;7(8):678-86
pubmed: 8500693
Circ Res. 2009 Oct 23;105(9):869-75
pubmed: 19762680
Sci Rep. 2017 Apr 7;7(1):744
pubmed: 28389645
Hypertension. 2002 Oct;40(4):552-9
pubmed: 12364362
Psychophysiology. 2013 May;50(5):477-87
pubmed: 23445494
Brain Pathol. 2017 Mar;27(2):169-180
pubmed: 27062392
Am J Physiol Regul Integr Comp Physiol. 2011 Oct;301(4):R1067-77
pubmed: 21753145
J Psychosom Res. 2004 Oct;57(4):353-8
pubmed: 15518669
Stroke. 2009 Dec;40(12):3869-71
pubmed: 19850898
Methods Mol Biol. 2012;814:49-59
pubmed: 22144299
Cerebellum. 2017 Dec;16(5-6):913-922
pubmed: 28508170
Neurosurgery. 2012 Nov;71(5):E1064-5; author reply E1065-6
pubmed: 22902341
Am J Physiol. 1999 Jan;276(1):H326-32
pubmed: 9887047
Epilepsia. 1999 Jan;40(1):20-5
pubmed: 9924897
Hypertension. 2000 Dec;36(6):1023-8
pubmed: 11116119
Vet Res. 2016 Jun 28;47(1):68
pubmed: 27352927
Adv Physiol Educ. 2016 Sep;40(3):283-96
pubmed: 27445275
J Physiol. 2001 Jul 1;534(Pt 1):287-95
pubmed: 11433009
Mol Ther Methods Clin Dev. 2014 Aug 06;1:14032
pubmed: 26015973
Mol Neurobiol. 2019 Jun;56(6):4203-4214
pubmed: 30291583
J Neurosci Methods. 2020 Mar 1;333:108541
pubmed: 31838183
J Cell Biol. 2008 Dec 29;183(7):1243-57
pubmed: 19114593
Cochrane Database Syst Rev. 2014 Aug 22;(8):CD009096
pubmed: 25148386
Am J Med. 1965 Sep;39:442-51
pubmed: 14338295
Mayo Clin Proc. 2014 Mar;89(3):327-34
pubmed: 24582191
Microvasc Res. 1994 Nov;48(3):303-15
pubmed: 7731395
Biomech Model Mechanobiol. 2013 Jan;12(1):111-21
pubmed: 22411016
J Biomech. 1994 Mar;27(3):339-60
pubmed: 8051194
Am J Hypertens. 2003 Nov;16(11 Pt 1):966-72
pubmed: 14573336
Nat Rev Mol Cell Biol. 2014 Dec;15(12):825-33
pubmed: 25355507
Curr Stem Cell Res Ther. 2017;12(6):455-470
pubmed: 28270089
Cell Rep. 2019 Nov 19;29(8):2192-2201.e3
pubmed: 31747594
Mol Cell Endocrinol. 2016 Dec 5;437:130-141
pubmed: 27539920
Exp Gerontol. 2010 May;45(5):357-65
pubmed: 20156544
Nat Cell Biol. 2004 Jun;6(6):499-506
pubmed: 15146194
Mol Ther. 2019 Apr 10;27(4):700-704
pubmed: 30842039
Cardiovasc Res. 2010 Aug 1;87(3):578-84
pubmed: 20200044
Exp Physiol. 2014 Dec 1;99(12):1597-610
pubmed: 25239924
J Hypertens. 1997 Jun;15(6):651-7
pubmed: 9218185
Circ Res. 2015 Mar 13;116(6):976-90
pubmed: 25767284
Exp Cell Res. 2012 Jan 1;318(1):75-84
pubmed: 22020089
iScience. 2020 Feb 21;23(2):100874
pubmed: 32062453
Physiol Rev. 2010 Apr;90(2):513-57
pubmed: 20393193
Immunity. 2017 Jun 20;46(6):957-967
pubmed: 28636962
J Physiol. 2009 Dec 1;587(Pt 23):5551-8
pubmed: 19736305
Lancet. 2012 Dec 15;380(9859):2224-60
pubmed: 23245609
PLoS One. 2014 May 01;9(5):e94927
pubmed: 24788542
J Hypertens. 2018 Apr;36(4):801-808
pubmed: 29493561
Can J Physiol Pharmacol. 1997 Jul;75(7):796-806
pubmed: 9315346
J Neurooncol. 1997 May;32(3):193-201
pubmed: 9049880
Sci Adv. 2019 Sep 25;5(9):eaau7802
pubmed: 31579816
Hypertens Res. 2012 May;35(5):477-84
pubmed: 22399095
Am J Hypertens. 2008 Nov;21(11):1188-93
pubmed: 18787517
Sci Rep. 2020 May 6;10(1):7628
pubmed: 32376984
Neuropharmacology. 2006 Jun;50(7):874-83
pubmed: 16487550
Hypertension. 2013 Jun;61(6):1203-10
pubmed: 23529167
Nat Rev Neurosci. 2006 May;7(5):335-46
pubmed: 16760914
Biomed Eng Online. 2006 Jun 06;5:36
pubmed: 16756664
Front Cardiovasc Med. 2022 Apr 15;9:854726
pubmed: 35498012
Clin Exp Hypertens. 2012;34(4):278-83
pubmed: 22578069
J Hypertens. 2013 Apr;31(4):720-9
pubmed: 23337468
Circulation. 2000 Feb 29;101(8):886-92
pubmed: 10694528
Clin Sci. 1972 May;42(5):579-90
pubmed: 5032889
Hypertension. 2001 Oct;38(4):896-901
pubmed: 11641305
Curr Hypertens Rep. 2015 Nov;17(11):87
pubmed: 26423529
Cell Mol Neurobiol. 2016 Mar;36(2):259-79
pubmed: 26993513
Am J Physiol. 1993 Feb;264(2 Pt 2):R388-95
pubmed: 8447494
J Neurotrauma. 2004 Aug;21(8):994-1007
pubmed: 15318999
Brain Res. 1994 Mar 21;640(1-2):40-7
pubmed: 8004465
Hypertension. 2021 Jan;77(1):147-157
pubmed: 33296248
Nature. 2003 Oct 30;425(6961):917-25
pubmed: 14586460
Front Physiol. 2013 Feb 20;4:26
pubmed: 23431279
Physiol Behav. 2013 Sep 10;121:96-102
pubmed: 23458630
Prog Neurobiol. 2017 Oct;157:230-246
pubmed: 26837044
Sports Med. 2000 Sep;30(3):193-206
pubmed: 10999423
APL Bioeng. 2018 Sep;2(3):
pubmed: 30456343
Am J Hypertens. 2003 Apr;16(4):312-8
pubmed: 12670749
Physiol Rev. 2018 Jul 1;98(3):1627-1738
pubmed: 29873596
J Hypertens. 1996 Nov;14(11):1317-24
pubmed: 8934360
Curr Pharm Des. 2013;19(17):3043-8
pubmed: 23176217
Physiol Rev. 1994 Apr;74(2):323-64
pubmed: 8171117
J Neurosci. 1993 Feb;13(2):559-67
pubmed: 8381167
Front Neurosci. 2022 Feb 17;16:848079
pubmed: 35250473
J Clin Monit Comput. 2021 Dec;35(6):1349-1356
pubmed: 33094826
Cell Metab. 2007 Jun;5(6):464-75
pubmed: 17550781
Hypertens Res. 2019 Sep;42(9):1235-1481
pubmed: 31375757
J Biol Chem. 2013 Jan 25;288(4):2655-64
pubmed: 23172225
Circulation. 2000 Jan 25;101(3):329-35
pubmed: 10645931
Hum Gene Ther. 1999 Jan 20;10(2):201-13
pubmed: 10022545
Circ Res. 1986 Aug;59(2):178-93
pubmed: 2874900
Phys Rev Lett. 2019 Jun 21;122(24):245502
pubmed: 31322393
Cerebellum. 2014 Feb;13(1):29-41
pubmed: 23955261
Biomed Pharmacother. 2019 Aug;116:108996
pubmed: 31132670
Science. 2010 Nov 5;330(6005):774-8
pubmed: 21051628
Hypertens Res. 2016 Mar;39(3):119-26
pubmed: 26399454
Cell Metab. 2011 Apr 6;13(4):469-475
pubmed: 21459331