Coordinated Priming of NKG2D Pathway by IL-15 Enhanced Functional Properties of Cytotoxic CD4
cytolytic function
cytotoxic CD4+CD28− T cells
inflammation
interleukin-15-NKG2D
tissue damage
Journal
Inflammation
ISSN: 1573-2576
Titre abrégé: Inflammation
Pays: United States
ID NLM: 7600105
Informations de publication
Date de publication:
Oct 2023
Oct 2023
Historique:
received:
07
04
2023
accepted:
16
06
2023
revised:
27
05
2023
medline:
12
10
2023
pubmed:
7
7
2023
entrez:
6
7
2023
Statut:
ppublish
Résumé
Systemic lupus erythematosus (SLE) is a systemic autoimmune disorder, and numerous aberrations of T cell responses have been reported and were implicated in its pathophysiology. Recently, CD4-positive T cells with cytotoxic potential were shown to be involved in autoimmune disease progression and tissue damage. However, the effector functions of this cell type and their potential molecular mechanisms in SLE patients remain to be elucidated. In this study, we find that cytotoxic CD4
Identifiants
pubmed: 37415045
doi: 10.1007/s10753-023-01860-z
pii: 10.1007/s10753-023-01860-z
pmc: PMC10567942
doi:
Substances chimiques
CD28 Antigens
0
Interleukin-15
0
NK Cell Lectin-Like Receptor Subfamily K
0
Phosphatidylinositol 3-Kinases
EC 2.7.1.-
Antineoplastic Agents
0
Types de publication
Letter
Langues
eng
Sous-ensembles de citation
IM
Pagination
1587-1601Subventions
Organisme : National Natural Science Foundation of China
ID : 82201996
Organisme : National Natural Science Foundation of China
ID : 81971464
Organisme : Guangdong Basic and Applied Basic Research Fund
ID : 2021A1515111072
Organisme : Science and innovation commission of shenzhen municipality
ID : JCYJ20220530151811025
Informations de copyright
© 2023. The Author(s).
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