Treatment Options for Anemia in Kidney Transplant Patients: A Review.
Anemia
HIF inhibitors
erythropoiesis-stimulating agent
graft failure
iron
kidney transplantation
Journal
Kidney medicine
ISSN: 2590-0595
Titre abrégé: Kidney Med
Pays: United States
ID NLM: 101756300
Informations de publication
Date de publication:
Aug 2023
Aug 2023
Historique:
medline:
7
7
2023
pubmed:
7
7
2023
entrez:
7
7
2023
Statut:
epublish
Résumé
Anemia is common after kidney transplantation. The etiology may be multifactorial, such as causes of anemia in the general population and causes that are unique to the kidney transplant setting. Posttransplant anemia, particularly when severe, may be associated with adverse effects such as graft failure, mortality, and a decline in kidney function. After careful investigation, that is, having excluded or treated reversible causes of anemia, treatment of anemia in patients with a kidney transplant is based on iron supplementation or erythropoiesis-stimulating agents (ESA), although there are no specific guidelines on anemia management in this patient population. Iron therapy is often needed, but optimal and safe iron-deficiency management strategies remain to be defined. Evidence suggests that ESAs are safe and potentially associated with favorable outcomes. Better graft function has been reported with ESA use targeting hemoglobin levels higher than those recommended in the general population with chronic kidney disease and with no apparent increased risk of cardiovascular events. These results require further investigation. Data on the use of hypoxia-inducible factor inhibitors are limited. Prevention and treatment of anemia in kidney transplantation can improve patients' quality of life, life expectancy, allograft function, and survival.
Identifiants
pubmed: 37415623
doi: 10.1016/j.xkme.2023.100681
pii: S2590-0595(23)00097-3
pmc: PMC10320602
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
100681Informations de copyright
© 2023 The Authors.
Références
Clin Transplant. 2022 May;36(5):e14602
pubmed: 35073452
Acta Haematol. 2019;142(1):37-43
pubmed: 30970356
Medicine (Baltimore). 2017 Aug;96(32):e7735
pubmed: 28796058
Prog Transplant. 2023 Mar;33(1):78-89
pubmed: 36591924
Drugs Context. 2021 Jan 19;10:
pubmed: 33519940
Transplantation. 2006 Apr 27;81(8):1112-8
pubmed: 16641595
PLoS Med. 2019 Jun 6;16(6):e1002818
pubmed: 31170159
Transpl Immunol. 2023 Apr;77:101807
pubmed: 36842568
Biomed Res Int. 2017;2017:6987240
pubmed: 28401160
J Am Soc Nephrol. 2006 Mar;17(3):889-99
pubmed: 16481415
Front Immunol. 2022 May 31;13:854850
pubmed: 35711440
Curr Opin Nephrol Hypertens. 2023 Jan 1;32(1):35-40
pubmed: 36250458
BMC Nephrol. 2017 Jan 11;18(1):14
pubmed: 28077085
Transplant Proc. 2022 Mar;54(2):544-548
pubmed: 35120763
J Am Soc Nephrol. 2002 Apr;13(4):1084-1090
pubmed: 11912270
Eur J Nutr. 2015 Aug;54(5):709-19
pubmed: 25096756
Transplant Proc. 2022 Jan-Feb;54(1):91-93
pubmed: 34973841
Ann Palliat Med. 2021 Nov;10(11):11859-11867
pubmed: 34872310
Transpl Int. 2021 Jul;34(7):1212-1225
pubmed: 33884674
Nephrol Dial Transplant. 2022 Feb 25;37(3):409-420
pubmed: 33150431
Kidney Int. 2015 Mar;87(3):527-34
pubmed: 25296093
Clin J Am Soc Nephrol. 2013 Nov;8(11):1968-78
pubmed: 23929933
N Engl J Med. 2006 Nov 16;355(20):2085-98
pubmed: 17108343
Transpl Int. 2016 Nov;29(11):1176-1183
pubmed: 27516242
Kidney Int. 1987 Oct;32(4):526-36
pubmed: 3323595
Transplantation. 2012 Apr 27;93(8):822-6
pubmed: 22290270
Clin Transplant. 2013 Nov-Dec;27(6):E636-43
pubmed: 23991916
Transplant Proc. 2014 Nov;46(9):3179-82
pubmed: 25420853
Transplant Proc. 2022 Apr;54(3):671-677
pubmed: 35256197
Iran J Kidney Dis. 2012 Jan;6(1):44-8
pubmed: 22218119
Clin Exp Nephrol. 2009 Aug;13(4):355-360
pubmed: 19352589
Medicina (B Aires). 2020;80(6):611-621
pubmed: 33254105
Int Urol Nephrol. 2015 Sep;47(9):1577-85
pubmed: 26246037
Am J Transplant. 2004 Dec;4(12):2075-81
pubmed: 15575912
Neth J Med. 2017 Mar;75(2):65-73
pubmed: 28276325
Nutr Clin Pract. 2022 Feb;37(1):81-93
pubmed: 33979013
Am J Kidney Dis. 2010 Sep;56(3):558-65
pubmed: 20400218
Transpl Immunol. 2022 Oct;74:101667
pubmed: 35835294
Nat Rev Nephrol. 2015 Jul;11(7):394-410
pubmed: 26055355
Biomed Pharmacother. 2017 Jun;90:229-236
pubmed: 28363168
J Clin Pharm Ther. 2022 Dec;47(12):1895-1912
pubmed: 36250775
J Am Soc Nephrol. 2011 May;22(5):956-66
pubmed: 21436289
Transpl Int. 2015 Mar;28(3):330-40
pubmed: 25516244
Nephrol Dial Transplant. 2019 Aug 1;34(8):1409-1416
pubmed: 30561729
J Pers Med. 2022 Jul 23;12(8):
pubmed: 35893294
J Am Soc Nephrol. 2017 Aug;28(8):2377-2392
pubmed: 28302753
N Engl J Med. 2019 Jan 31;380(5):447-458
pubmed: 30365356
Exp Clin Transplant. 2020 Feb;18(1):27-33
pubmed: 31180297
Transplantation. 2005 Feb 15;79(3):367-8
pubmed: 15699772
J Clin Invest. 1997 Nov 1;100(9):2310-4
pubmed: 9410909
Clin Transplant. 1994 Aug;8(4):358-64
pubmed: 7949539
JAMA Surg. 2018 Sep 1;153(9):826-833
pubmed: 29898202
Nephrol Dial Transplant. 2021 Nov 9;36(11):1976-1985
pubmed: 32910168
Am J Transplant. 2007 Apr;7(4):818-24
pubmed: 17391125
J Clin Med. 2019 Sep 03;8(9):
pubmed: 31484461
Nephrol Dial Transplant. 2006 Dec;21(12):3559-66
pubmed: 17040993
Clin Transplant. 2012 May-Jun;26(3):461-9
pubmed: 22066719
Am J Nephrol. 2017;46(4):343-354
pubmed: 29024935
Am J Kidney Dis. 2005 Oct;46(4):720-33
pubmed: 16183428
Nephrol Dial Transplant. 2009 Feb;24(2):348-54
pubmed: 19037082
J Am Soc Nephrol. 2006 Nov;17(11):3240-7
pubmed: 17035616
Am J Nephrol. 2020;51(5):349-356
pubmed: 32241009
N Engl J Med. 2009 Nov 19;361(21):2019-32
pubmed: 19880844
Hematology Am Soc Hematol Educ Program. 2010;2010:281-6
pubmed: 21239807
Kidney Int. 2003 Apr;63(4):1187-94
pubmed: 12631334
Am J Kidney Dis. 2006 Oct;48(4):519-36
pubmed: 16997048
Am J Transplant. 2003 Jul;3(7):835-45
pubmed: 12814475
Int J Nephrol Renovasc Dis. 2021 Jul 02;14:211-223
pubmed: 34239319
Int Urol Nephrol. 2012 Feb;44(1):263-8
pubmed: 21170586
Pediatr Nephrol. 2022 Oct 25;:
pubmed: 36282330
Clin Nephrol. 2009 Feb;71(2):125-9
pubmed: 19203504
Am J Kidney Dis. 2016 Nov;68(5):677-690
pubmed: 27321965
Transfusion. 2022 Dec;62(12):2480-2489
pubmed: 36325656
Am J Transplant. 2009 Nov;9 Suppl 3:S1-155
pubmed: 19845597
J Am Soc Nephrol. 2003 Feb;14(2):462-8
pubmed: 12538748
Am J Kidney Dis. 2013 Nov;62(5):849-59
pubmed: 23891356
BMC Nephrol. 2019 Feb 13;20(1):51
pubmed: 30760235
Kidney Int. 2012 May;81(9):903-18
pubmed: 22318420
Clin Transplant. 2012 Jul-Aug;26(4):608-14
pubmed: 22404716
Am J Kidney Dis. 2016 Jan;67(1):133-42
pubmed: 26372086
Am J Kidney Dis. 2022 Jun;79(6):868-876
pubmed: 34758368
J Am Soc Nephrol. 2017 Dec;28(12):3605-3615
pubmed: 28784700
Br J Clin Pharmacol. 2021 May;87(5):2256-2273
pubmed: 33188534
N Engl J Med. 2006 Nov 16;355(20):2071-84
pubmed: 17108342
Transplant Proc. 2012 Nov;44(9):2593-5
pubmed: 23146465
J Am Soc Nephrol. 2012 Feb;23(2):360-8
pubmed: 22193388
Br J Clin Pharmacol. 1992 Oct;34(4):363-5
pubmed: 1457271