Visualizing Arc protein dynamics and localization in the mammalian brain using AAV-mediated

AAV HITI PLA cell–cell transfer retrotransposon synaptic plasticity

Journal

Frontiers in molecular neuroscience
ISSN: 1662-5099
Titre abrégé: Front Mol Neurosci
Pays: Switzerland
ID NLM: 101477914

Informations de publication

Date de publication:
2023
Historique:
received: 09 01 2023
accepted: 11 05 2023
medline: 7 7 2023
pubmed: 7 7 2023
entrez: 7 7 2023
Statut: epublish

Résumé

The activity-regulated cytoskeleton-associated (Arc) protein is essential for synaptic plasticity and memory formation. The Arc gene, which contains remnants of a structural GAG retrotransposon sequence, produces a protein that self-assembles into capsid-like structures harboring Arc mRNA. Arc capsids, released from neurons, have been proposed as a novel intercellular mechanism for mRNA transmission. Nevertheless, evidence for intercellular transport of Arc in the mammalian brain is still lacking. To enable the tracking of Arc molecules from individual neurons

Identifiants

pubmed: 37415832
doi: 10.3389/fnmol.2023.1140785
pmc: PMC10321715
doi:

Types de publication

Journal Article

Langues

eng

Pagination

1140785

Informations de copyright

Copyright © 2023 Avallone, Pardo, Mergiya, Rajova, Räsänen, Davidsson, Åkerblom, Quintino, Kumar, Bramham and Björklund.

Déclaration de conflit d'intérêts

DK was employed by Aiforia Technologies Oyj. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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Auteurs

Martino Avallone (M)

Molecular Neuromodulation, Wallenberg Neuroscience Center, Lund University, Lund, Sweden.

Joaquín Pardo (J)

Molecular Neuromodulation, Wallenberg Neuroscience Center, Lund University, Lund, Sweden.
Instituto de Investigaciones Bioquímicas de La Plata "Prof. Dr. Rodolfo R. Brenner" (INIBIOLP), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET)-Universidad Nacional de La Plata (UNLP), La Plata, Argentina.

Tadiwos F Mergiya (TF)

Department of Biomedicine, University of Bergen, Bergen, Norway.
Mohn Research Center for the Brain, University of Bergen, Bergen, Norway.

Jana Rájová (J)

Molecular Neuromodulation, Wallenberg Neuroscience Center, Lund University, Lund, Sweden.

Atte Räsänen (A)

Molecular Neuromodulation, Wallenberg Neuroscience Center, Lund University, Lund, Sweden.

Marcus Davidsson (M)

Molecular Neuromodulation, Wallenberg Neuroscience Center, Lund University, Lund, Sweden.

Malin Åkerblom (M)

Molecular Neuromodulation, Wallenberg Neuroscience Center, Lund University, Lund, Sweden.

Luis Quintino (L)

CNS Gene Therapy, Department of Experimental Medical Sciences, Lund University, Lund, Sweden.

Darshan Kumar (D)

Aiforia Technologies Oyj, Helsinki, Finland.

Clive R Bramham (CR)

Department of Biomedicine, University of Bergen, Bergen, Norway.
Mohn Research Center for the Brain, University of Bergen, Bergen, Norway.

Tomas Björklund (T)

Molecular Neuromodulation, Wallenberg Neuroscience Center, Lund University, Lund, Sweden.

Classifications MeSH