Mu-opioid receptor selective superagonists produce prolonged respiratory depression.
Cellular neuroscience
Molecular neuroscience
Neuroscience
Journal
iScience
ISSN: 2589-0042
Titre abrégé: iScience
Pays: United States
ID NLM: 101724038
Informations de publication
Date de publication:
21 Jul 2023
21 Jul 2023
Historique:
received:
22
11
2022
revised:
17
03
2023
accepted:
09
06
2023
medline:
7
7
2023
pubmed:
7
7
2023
entrez:
7
7
2023
Statut:
epublish
Résumé
Synthetic opioids are increasingly challenging to combat the opioid epidemic and act primarily at opioid receptors, chiefly the G protein-coupled receptor (GPCR) μ-opioid receptor (MOR), which signals through G protein-dependent and β-arrestin pathways. Using a bioluminescence resonance energy transfer (BRET) system, we investigate GPCR-signaling profiles by synthetic nitazenes, which are known to cause overdose and death due to respiratory depression. We show that isotonitazene and its metabolite,
Identifiants
pubmed: 37416459
doi: 10.1016/j.isci.2023.107121
pii: S2589-0042(23)01198-7
pmc: PMC10320493
doi:
Types de publication
Journal Article
Langues
eng
Pagination
107121Subventions
Organisme : NIGMS NIH HHS
ID : T32 GM080202
Pays : United States
Informations de copyright
© 2023 The Author(s).
Déclaration de conflit d'intérêts
The authors declare no competing financial interests.
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