Nutraceuticals as Modulators of Immune Function: A Review of Potential Therapeutic Effects.
dietary supplements
immunomodulation
infections
nutraceuticals
Journal
Preventive nutrition and food science
ISSN: 2287-1098
Titre abrégé: Prev Nutr Food Sci
Pays: Korea (South)
ID NLM: 101586663
Informations de publication
Date de publication:
30 Jun 2023
30 Jun 2023
Historique:
received:
13
12
2022
revised:
27
02
2023
accepted:
03
03
2023
medline:
7
7
2023
pubmed:
7
7
2023
entrez:
7
7
2023
Statut:
ppublish
Résumé
Dietary supplementation with nutraceuticals can promote optimal immune system activation, modulating different pathways that enhance immune defenses. Therefore, the immunity-boosting effects of nutraceuticals encompass not only immunomodulatory but also antioxidant, antitumor, antiviral, antibacterial, and antifungal properties, with therapeutic effects against diverse pathological conditions. However, the complexity of the pathways that regulate the immune system, numerous mechanisms of action, and heterogeneity of the immunodeficiencies, and subjects treated make their application in the clinical field difficult. Some nutraceuticals appear to safely improve immune system function, particularly by preventing viral and bacterial infections in specific groups, such as children, the elderly, and athletes, as well as in frail patients, such as those affected by autoimmune diseases, chronic diseases, or cancer. Several nutraceuticals, such as vitamins, mineral salts, polyunsaturated omega-3 fatty acids, many types of phytocompounds, and probiotic strains, have the most consolidated evidence in humans. In most cases, further large and long-term randomized clinical trials are needed to confirm the available preliminary positive data.
Identifiants
pubmed: 37416796
doi: 10.3746/pnf.2023.28.2.89
pii: pnfs-28-2-89
pmc: PMC10321448
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
89-107Informations de copyright
Copyright © 2023 by The Korean Society of Food Science and Nutrition. All rights Reserved.
Déclaration de conflit d'intérêts
AUTHOR DISCLOSURE STATEMENT The authors declare no conflict of interest.
Références
Phytomedicine. 2021 Sep;90:153554
pubmed: 34371479
PLoS One. 2013 Oct 15;8(10):e77401
pubmed: 24143230
Br J Nutr. 2007 Oct;98 Suppl 1:S29-35
pubmed: 17922955
Int J Appl Basic Med Res. 2016 Oct-Dec;6(4):249-254
pubmed: 27857891
Cell Rep. 2020 Dec 1;33(9):108452
pubmed: 33264617
Daru. 2019 Jun;27(1):233-241
pubmed: 31134491
PLoS One. 2014 Apr 22;9(4):e96091
pubmed: 24755955
Front Immunol. 2019 Mar 01;10:345
pubmed: 30881359
Immunopharmacol Immunotoxicol. 1998 Feb;20(1):173-90
pubmed: 9543707
JAMA. 2004 Aug 18;292(7):828-36
pubmed: 15315997
Ann N Y Acad Sci. 2016 May;1372(1):53-64
pubmed: 27362360
Eur J Clin Nutr. 2007 Apr;61(4):443-60
pubmed: 17136044
Am J Epidemiol. 2006 Jan 1;163(1):18-26
pubmed: 16306311
Arch Pharm Res. 2022 Jun;45(6):367-389
pubmed: 35713852
Biochim Biophys Acta. 2007 Jul;1773(7):1116-23
pubmed: 17555831
Biosci Biotechnol Biochem. 2010;74(5):939-45
pubmed: 20460726
Pol J Vet Sci. 2009;12(3):399-405
pubmed: 19886264
J Nutr. 2010 Jul;140(7):1335-41
pubmed: 20484546
Immunology. 1979 Dec;38(4):727-34
pubmed: 316418
Free Radic Res. 2008 Mar;42(3):272-80
pubmed: 18344122
J Infect Dis. 1997 Jul;176(1):273-6
pubmed: 9207381
Molecules. 2021 Sep 01;26(17):
pubmed: 34500743
Exp Mol Med. 2015 Apr 24;47:e160
pubmed: 25907110
Arch Intern Med. 2009 Feb 23;169(4):384-90
pubmed: 19237723
J Immunol. 2006 Jul 15;177(2):1296-305
pubmed: 16818790
Int Immunopharmacol. 2013 Sep;17(1):79-87
pubmed: 23759204
Minerva Pediatr (Torino). 2021 Feb;73(1):59-66
pubmed: 26763692
Int J Biochem Cell Biol. 2007;39(5):955-65
pubmed: 17306601
Mech Ageing Dev. 1986 Apr;34(2):191-201
pubmed: 3487685
Eur J Clin Nutr. 2010 Sep;64(9):1007-13
pubmed: 20571496
Biology (Basel). 2021 Apr 01;10(4):
pubmed: 33916114
J Med Food. 2019 Jul;22(7):703-712
pubmed: 31066606
Nutr Diet Suppl. 2017;2017(9):37-45
pubmed: 29187783
Inflammopharmacology. 2018 Apr;26(2):319-330
pubmed: 29532213
J Am Coll Nutr. 2020 Nov-Dec;39(8):694-699
pubmed: 32659175
Immunol Lett. 2011 Mar 30;135(1-2):50-8
pubmed: 20933009
Drugs Exp Clin Res. 1990;16(10):537-42
pubmed: 2100737
Int Immunopharmacol. 2009 Apr;9(4):418-24
pubmed: 19185061
Integr Med. 2000 Mar 21;2(2):85-92
pubmed: 10882881
J Surg Res. 2004 Oct;121(2):171-7
pubmed: 15501456
Free Radic Biol Med. 2000 Mar 1;28(5):824-30
pubmed: 10754279
J Leukoc Biol. 2014 Dec;96(6):1165-75
pubmed: 25157026
Br J Sports Med. 2008 Oct;42(10):819-22
pubmed: 18048435
Clin Infect Dis. 2017 Sep 15;65(6):900-909
pubmed: 28531276
Eur J Appl Physiol. 2011 Sep;111(9):2033-40
pubmed: 21249381
FEBS Lett. 2000 Oct 13;483(1):78-82
pubmed: 11033360
Pharmacogn Rev. 2015 Jan-Jun;9(17):63-72
pubmed: 26009695
Phytother Res. 2006 May;20(5):424-5
pubmed: 16619374
Appl Physiol Nutr Metab. 2010 Dec;35(6):755-62
pubmed: 21164546
J Biol Chem. 1992 Nov 25;267(33):23988-92
pubmed: 1429735
Int Immunopharmacol. 2013 Feb;15(2):395-9
pubmed: 23261366
Free Radic Biol Med. 2022 Nov 20;193(Pt 2):736-750
pubmed: 36402440
Nature. 2009 Oct 29;461(7268):1287-91
pubmed: 19865173
Pharmacol Res. 2020 Jun;156:104754
pubmed: 32173584
Int Immunopharmacol. 2014 Sep;22(1):41-50
pubmed: 24975831
Nutrients. 2015 Apr 09;7(4):2574-88
pubmed: 25912037
Biomed Pharmacother. 2021 Nov;143:112175
pubmed: 34649336
Annu Rev Nutr. 2004;24:277-98
pubmed: 15189122
Molecules. 2020 Sep 12;25(18):
pubmed: 32932637
Semin Immunopathol. 2020 Oct;42(5):559-572
pubmed: 33165716
Atherosclerosis. 2013 Oct;230(2):365-72
pubmed: 24075769
J Nutr. 2016 Feb;146(2):433S-436S
pubmed: 26764332
Lancet. 1986 May 24;1(8491):1169-73
pubmed: 2871418
Infect Immun. 2015 Jul;83(7):2984-91
pubmed: 25964475
FASEB J. 1990 May;4(8):2518-27
pubmed: 2110538
Chin Med J (Engl). 1981 Jan;94(1):35-40
pubmed: 6164521
Drugs Exp Clin Res. 1996;22(2):65-72
pubmed: 8879982
Molecules. 2013 Mar 13;18(3):3292-311
pubmed: 23486107
PLoS One. 2010 Dec 17;5(12):e15150
pubmed: 21179414
J Biol Regul Homeost Agents. 2015 Apr-Jun;29(2):283-8
pubmed: 26122215
J Inflamm (Lond). 2016 Nov 28;13:36
pubmed: 27932936
Front Physiol. 2020 Jun 19;11:752
pubmed: 32636763
Phytomedicine. 2021 Nov;92:153717
pubmed: 34583224
Clin Nutr ESPEN. 2018 Apr;24:148-155
pubmed: 29576354
Asian Pac J Allergy Immunol. 2016 Dec;34(4):249-264
pubmed: 28042926
Exp Gerontol. 1999 Nov;34(7):853-62
pubmed: 10622420
J Family Med Prim Care. 2022 Jul;11(7):3784-3789
pubmed: 36387710
J Allergy Clin Immunol. 2009 May;123(5):1004-11
pubmed: 19410689
Biogerontology. 2005;6(4):271-81
pubmed: 16333761
Biochim Biophys Acta. 2000 Jun 15;1501(2-3):91-8
pubmed: 10838183
J Nutr Biochem. 2003 Feb;14(2):90-8
pubmed: 12667600
J Nutr. 1990 Sep;120(9):1096-102
pubmed: 2144586
Plants (Basel). 2022 May 05;11(9):
pubmed: 35567246
Oxid Med Cell Longev. 2013;2013:707421
pubmed: 24069505
J Agric Food Chem. 2016 May 11;64(18):3591-7
pubmed: 27112424
Endocr Metab Immune Disord Drug Targets. 2014;14(4):272-82
pubmed: 25307109
Clin Exp Immunol. 1999 Apr;116(1):28-32
pubmed: 10209501
Osteoporos Int. 2005 Jul;16(7):713-6
pubmed: 15776217
Biol Pharm Bull. 2011;34(1):97-102
pubmed: 21212525
Proc Natl Acad Sci U S A. 2014 Aug 19;111(33):E3432-40
pubmed: 25099355
Nutrients. 2019 Feb 04;11(2):
pubmed: 30720717
Ageing Res Rev. 2021 Sep;70:101410
pubmed: 34280555
Cochrane Database Syst Rev. 2013 Jan 31;(1):CD000980
pubmed: 23440782
Food Funct. 2022 Mar 7;13(5):2415-2426
pubmed: 35174827
Ann Rheum Dis. 2012 Jan;71(1):129-35
pubmed: 21953348
Science. 2003 May 30;300(5624):1439-43
pubmed: 12775843
Complement Ther Med. 2019 Jun;44:18-26
pubmed: 31126553
J Nutr. 2003 May;133(5 Suppl 1):1460S-2S
pubmed: 12730443
J Agric Food Chem. 2018 Nov 7;66(44):11630-11639
pubmed: 30350973
Nutrients. 2018 Nov 03;10(11):
pubmed: 30400332
Eur Rev Med Pharmacol Sci. 2016 Dec;20(23):5009-5012
pubmed: 27981530
Chem Immunol Allergy. 2012;96:39-44
pubmed: 22433369
Eur J Clin Nutr. 2006 Oct;60(10):1207-13
pubmed: 16670691
Nutr Rev. 2010 Apr;68(4):191-206
pubmed: 20416016
Allergy Asthma Immunol Res. 2018 Nov;10(6):575-590
pubmed: 30306743
J Immunol Res. 2017;2017:8081642
pubmed: 29214185
Clin Biochem. 1991 Apr;24(2):211-4
pubmed: 2040094
J Nutr Biochem. 2014 Dec;25(12):1275-81
pubmed: 25294776
Annu Rev Nutr. 2009;29:133-52
pubmed: 19400701
J Pediatr Nurs. 2022 Jan-Feb;62:e60-e68
pubmed: 34366195
Nutrients. 2021 Apr 17;13(4):
pubmed: 33920583
Am J Clin Nutr. 2001 Dec;74(6):833-9
pubmed: 11722966
Allergy Asthma Clin Immunol. 2018 Sep 12;14(Suppl 2):49
pubmed: 30263032
J Surg Res. 1998 Jul 1;77(2):174-8
pubmed: 9733605
Eur J Immunol. 2015 May;45(5):1287-95
pubmed: 25808452
Nat Rev Immunol. 2021 Mar;21(3):137-150
pubmed: 32782357
Med Drug Discov. 2020 Sep;7:100051
pubmed: 32835212
Curr Biol. 2011 Nov 8;21(21):R877-83
pubmed: 22075424
Mech Ageing Dev. 1995 Aug 31;83(1):43-53
pubmed: 8523901
PLoS One. 2017 Jun 30;12(6):e0179540
pubmed: 28665937
Am J Physiol Cell Physiol. 2001 Jun;280(6):C1570-5
pubmed: 11350752
Anat Cell Biol. 2010 Mar;43(1):25-35
pubmed: 21190002
J Acquir Immune Defic Syndr Hum Retrovirol. 1997 Aug 15;15(5):370-4
pubmed: 9342257
Food Funct. 2021 Apr 26;12(8):3366-3380
pubmed: 33876798
Nutrients. 2018 Oct 21;10(10):
pubmed: 30347877
Biomed Res Int. 2015;2015:501792
pubmed: 26339618
Arch Toxicol. 1996;70(5):277-83
pubmed: 8852698
Biochem Pharmacol. 2020 Jun;176:113824
pubmed: 31987852
Pharm Biol. 2017 Dec;55(1):649-656
pubmed: 27951745
IUBMB Life. 2019 Apr;71(4):487-494
pubmed: 30501009
Immunology. 2000 Aug;100(4):487-93
pubmed: 10929076
J Nutr. 2006 Mar;136(3 Suppl):816S-820S
pubmed: 16484572
J Trace Elem Med Biol. 2018 Dec;50:482-488
pubmed: 29439842
Nature. 2007 Feb 8;445(7128):648-51
pubmed: 17187052
J Altern Complement Med. 2009 Apr;15(4):423-30
pubmed: 19388865
J Clin Invest. 2002 Sep;110(5):681-90
pubmed: 12208869
FASEB J. 2007 Oct;21(12):3162-70
pubmed: 17496159
Lancet Infect Dis. 2007 Jul;7(7):473-80
pubmed: 17597571
Magnesium. 1988;7(5-6):290-9
pubmed: 3075245
Eur J Immunol. 1995 Jun;25(6):1673-9
pubmed: 7614995
J Clin Med. 2018 Sep 06;7(9):
pubmed: 30200565
J Immunol. 2012 Sep 1;189(5):2597-605
pubmed: 22844113
Free Radic Biol Med. 2019 Feb 1;131:309-317
pubmed: 30578916
Microbiol Immunol. 2007;51(1):25-35
pubmed: 17237596
Lupus. 2022 Jan;31(1):125-132
pubmed: 35006029
Ecotoxicol Environ Saf. 2021 Dec 1;225:112779
pubmed: 34530259
J Nutr. 1986 Apr;116(4):675-81
pubmed: 3485709
Nutrition. 2007 Feb;23(2):157-63
pubmed: 17150331
Nutrients. 2021 Feb 25;13(3):
pubmed: 33668814
Nutrients. 2018 Nov 01;10(11):
pubmed: 30388871
J Investig Med. 2011 Aug;59(6):881-6
pubmed: 21527855
Br J Nutr. 1972 Mar;27(2):299-304
pubmed: 5015249
J Nutr. 2016 Feb;146(2):389S-396S
pubmed: 26764326
Prog Lipid Res. 2012 Jul;51(3):232-7
pubmed: 22542696
Int J Gynecol Cancer. 2004 Jul-Aug;14(4):589-94
pubmed: 15304151
Front Immunol. 2021 Feb 26;12:578386
pubmed: 33717063
Cell Mol Immunol. 2020 May;17(5):462-473
pubmed: 31171862
J Am Vet Med Assoc. 1973 Sep 15;163(6):605-12
pubmed: 4742088
BMC Public Health. 2011 Apr 13;11 Suppl 3:S20
pubmed: 21501438
Cytotherapy. 2015 May;17(5):613-20
pubmed: 25747742
Arthritis Rheum. 2008 Jul;58(7):2012-8
pubmed: 18576345
Br J Clin Pharmacol. 2018 Apr;84(4):659-672
pubmed: 29433155
J Am Coll Nutr. 2015;34(6):478-87
pubmed: 25866155
Int Immunol. 2010 May;22(5):375-86
pubmed: 20215335
Nutr Res. 2020 Mar;75:85-94
pubmed: 32109839
J Appl Physiol (1985). 2002 May;92(5):1970-7
pubmed: 11960947
Cell Physiol Biochem. 2014;33(2):289-99
pubmed: 24525691
Clin Rheumatol. 2018 Aug;37(8):2035-2042
pubmed: 29611086
J Clin Transl Res. 2021 May 27;7(3):333-376
pubmed: 34239993
Nature. 2007 Jun 14;447(7146):869-74
pubmed: 17568749
J Med Food. 2021 Oct;24(10):1039-1049
pubmed: 34668764
Ageing Res Rev. 2021 Nov;71:101422
pubmed: 34391943
Anticancer Agents Med Chem. 2015;15(3):314-26
pubmed: 25403166
Am J Clin Nutr. 2010 May;91(5):1255-60
pubmed: 20219962
Curr Issues Mol Biol. 2022 May 23;44(5):2387-2400
pubmed: 35678692