Electrocardiogram analysis in Anderson-Fabry disease: a valuable tool for progressive phenotypic expression tracking.
Anderson-Fabry disease
ECG pattern
bundle branch block
cardiac involvement
electrocardiogram (ECG)
left ventricular hyperertrophy
repolarization abnormalities
Journal
Frontiers in cardiovascular medicine
ISSN: 2297-055X
Titre abrégé: Front Cardiovasc Med
Pays: Switzerland
ID NLM: 101653388
Informations de publication
Date de publication:
2023
2023
Historique:
received:
11
03
2023
accepted:
09
06
2023
medline:
7
7
2023
pubmed:
7
7
2023
entrez:
7
7
2023
Statut:
epublish
Résumé
Electrocardiogram (ECG) has proven to be useful for early detection of cardiac involvement in Anderson-Fabry disease (AFD); however, little evidence is available on the association between ECG alterations and the progression of the disease. To perform a cross sectional comparison of ECG abnormalities throughout different left ventricular hypertrophy (LVH) severity subgroups, providing ECG patterns specific of the progressive AFD stages. 189 AFD patients from a multicenter cohort underwent comprehensive ECG analysis, echocardiography, and clinical evaluation. The study cohort (39% males, median age 47 years, 68% classical AFD) was divided into 4 groups according to different degree of left ventricular (LV) thickness: group A ≤ 9 mm ( ECG is a sensitive tool for early identification and long-term monitoring of cardiac involvement in patients with AFD, providing "instantaneous pictures" along the natural history of AFD. Whether ECG changes may be associated with clinical events remains to be determined.
Sections du résumé
Background
UNASSIGNED
Electrocardiogram (ECG) has proven to be useful for early detection of cardiac involvement in Anderson-Fabry disease (AFD); however, little evidence is available on the association between ECG alterations and the progression of the disease.
Aim and Methods
UNASSIGNED
To perform a cross sectional comparison of ECG abnormalities throughout different left ventricular hypertrophy (LVH) severity subgroups, providing ECG patterns specific of the progressive AFD stages. 189 AFD patients from a multicenter cohort underwent comprehensive ECG analysis, echocardiography, and clinical evaluation.
Results
UNASSIGNED
The study cohort (39% males, median age 47 years, 68% classical AFD) was divided into 4 groups according to different degree of left ventricular (LV) thickness: group A ≤ 9 mm (
Conclusions
UNASSIGNED
ECG is a sensitive tool for early identification and long-term monitoring of cardiac involvement in patients with AFD, providing "instantaneous pictures" along the natural history of AFD. Whether ECG changes may be associated with clinical events remains to be determined.
Identifiants
pubmed: 37416917
doi: 10.3389/fcvm.2023.1184361
pmc: PMC10320218
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1184361Informations de copyright
© 2023 Parisi, Baldassarre, Ferrara, Ditaranto, Barlocco, Lillo, Re, Marchi, Chiti, Di Nicola, Catalano, Barile, Schiavo, Ponziani, Saturi, Caponetti, Berardini, Graziosi, Pasquale, Salamon, Ferracin, Nardi, Capelli, Girelli, Gimeno Blanes, Biffi, Galiè, Olivotto, Graziani and Biagini.
Déclaration de conflit d'intérêts
The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The reviewer CDI declared a shared affiliation with the authors RL, FG to the handling editor at the time of review.
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