The impact of combined contraceptive vaginal ring on vaginal environment: an observational, longitudinal study.

To assess the relationship between combined contraceptive vaginal ring (CVR) and vaginal microbiome using 16S rRNA gene sequencing. We enrolled 20 women for 8 weeks in an open-label study using CVR (NuvaRing Bacterial distribution richness and equity did not significantly change after 2 months, and the dominant bacterial strain was Our results suggest that CVR does not adversely affect the composition and structure of the vaginal microbiome. However, special care should be taken in patients with a history of vestibulodynia and/or recurrent vulvovaginal infections. Contraceptive vaginal ring does not adversely affect vaginal microbiome except in the case of recurrent vulvovaginal infections or vestibulodynia.