Haemodynamic Effects on the Development and Stability of Atherosclerotic Plaques in Arterial Blood Vessel.
Atherosclerosis
Finite-element method
Necrotic core
Plaque stability
Journal
Interdisciplinary sciences, computational life sciences
ISSN: 1867-1462
Titre abrégé: Interdiscip Sci
Pays: Germany
ID NLM: 101515919
Informations de publication
Date de publication:
Dec 2023
Dec 2023
Historique:
received:
04
03
2023
accepted:
14
06
2023
revised:
13
06
2023
pubmed:
7
7
2023
medline:
7
7
2023
entrez:
7
7
2023
Statut:
ppublish
Résumé
Studying the formation and stability of atherosclerotic plaques in the hemodynamic field is essential for understanding the growth mechanism and preventive treatment of atherosclerotic plaques. In this paper, based on a multiplayer porous wall model, we established a two-way fluid-solid interaction with time-varying inlet flow. The lipid-rich necrotic core (LRNC) and stress in atherosclerotic plaque were described for analyzing the stability of atherosclerotic plaques during the plaque growth by solving advection-diffusion-reaction equations with finite-element method. It was found that LRNC appeared when the lipid levels of apoptotic materials (such as macrophages, foam cells) in the plaque reached a specified lower concentration, and increased with the plaque growth. LRNC was positively correlated with the blood pressure and was negatively correlated with the blood flow velocity. The maximum stress was mainly located at the necrotic core and gradually moved toward the left shoulder of the plaque with the plaque growth, which increases the plaque instability and the risk of the plaque shedding. The computational model may contribute to understanding the mechanisms of early atherosclerotic plaque growth and the risk of instability in the plaque growth.
Identifiants
pubmed: 37418092
doi: 10.1007/s12539-023-00576-w
pii: 10.1007/s12539-023-00576-w
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
616-632Subventions
Organisme : the National Nature Science Foundation of China
ID : No.12274200
Organisme : the National Nature Science Foundation of China
ID : No.11774088
Organisme : Hengyang science and technology plan projects
ID : No.202250045335
Informations de copyright
© 2023. International Association of Scientists in the Interdisciplinary Areas.
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