Fundus autofluorescence in uveitis: from pathogenesis to imaging interpretation.
Autofluorescence
Posterior uveitis
Uveitis
White dot syndrome
Journal
International ophthalmology
ISSN: 1573-2630
Titre abrégé: Int Ophthalmol
Pays: Netherlands
ID NLM: 7904294
Informations de publication
Date de publication:
Nov 2023
Nov 2023
Historique:
received:
21
05
2023
accepted:
26
06
2023
medline:
23
10
2023
pubmed:
7
7
2023
entrez:
7
7
2023
Statut:
ppublish
Résumé
This review aims to summarize the current fundus autofluorescence (FAF) ailment for diagnosis and follow-up of uveitis. A thorough literature search was performed in the PubMed database. FAF maps the retinal pigment epithelium's (RPE) health. Therefore, several posterior infectious and non. This fast, easy-to-perform, noninvasive technique can detect and manage infectious uveitis. FAF serves to understand pathophysiologic mechanisms of uveitis and is a valuable prognostic indicator of themselves.
Identifiants
pubmed: 37418226
doi: 10.1007/s10792-023-02803-1
pii: 10.1007/s10792-023-02803-1
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
4359-4371Informations de copyright
© 2023. The Author(s), under exclusive licence to Springer Nature B.V.
Références
Agarwal A, Pichi F, Invernizzi A, Grewal DS, Singh RB, Upadhyay A (2023) Stepwise approach for fundus imaging in the diagnosis and management of posterior uveitis. Surv Ophthalmol 29:S0039
Machemer R, Norton EW, Gass JD, Choromokos E (1970) Pseudofluorescence-a problem in interpretation of fluorescein angiograms. Am J Ophthalmol 70(1):1–10. https://doi.org/10.1016/0002-9394(70)90658-6
doi: 10.1016/0002-9394(70)90658-6
pubmed: 4987088
Delori FC, Dorey CK, Staurenghi G, Arend O, Goger DG, Weiter JJ (1995) In vivo fluorescence of the ocular fundus exhibits retinal pigment epithelium lipofuscin characteristics. Invest Ophthalmol Vis Sci 36(3):718–729
pubmed: 7890502
Pichi F, Abboud EB, Ghazi NG, Khan AO (2018) Fundus autofluorescence imaging in hereditary retinal diseases. Acta Ophthalmol 96(5):e549–e561. https://doi.org/10.1111/aos.13602
doi: 10.1111/aos.13602
pubmed: 29098804
Durrani K, Foster CS (2012) Fundus autofluorescence imaging in posterior uveitis. Semin Ophthalmol 27(5–6):228–235. https://doi.org/10.3109/08820538.2012.711414
doi: 10.3109/08820538.2012.711414
pubmed: 23163281
Bosch E, Horwitz J, Bok D (1993) Phagocytosis of outer segments by retinal pigment epithelium: phagosome-lysosome interaction. J Histochem Cytochem 41(2):253–263. https://doi.org/10.1177/41.2.8419462
doi: 10.1177/41.2.8419462
pubmed: 8419462
Meleth AD, Sen HN (2012) Use of fundus autofluorescence in the diagnosis and management of uveitis. Int Ophthalmol Clin 52(4):45–54. https://doi.org/10.1097/IIO.0b013e3182662ee9
doi: 10.1097/IIO.0b013e3182662ee9
pubmed: 22954928
pmcid: 3437035
Marchese A, Agarwal A, Moretti AG, Handa S, Modorati G, Querques G, Bandello F, Gupta V, Miserocchi E (2020) Advances in imaging of uveitis. Ther Adv Ophthalmol 12:2515841420917781. https://doi.org/10.1177/2515841420917781
doi: 10.1177/2515841420917781
pubmed: 32524072
pmcid: 7235656
Bittencourt MG, Hassan M, Halim MS, Afridi R et al (2019) Blue light versus green light fundus autofluorescence in normal subjects and in patients with retinochoroidopathy secondary to retinal and uveitic diseases. J Ophthalmic Inflamm Infect. https://doi.org/10.1186/s12348-018-0167-2
doi: 10.1186/s12348-018-0167-2
pubmed: 30617430
pmcid: 6325057
Oishi A, Miyata M, Numa S, Otsuka Y, Oishi M, Tsujikawa A (2019) Wide-field fundus autofluorescence imaging in patients with hereditary retinal degeneration: a literature review. Int J Retina and Vitreous 12:23. https://doi.org/10.1186/s40942-019-0173-z
doi: 10.1186/s40942-019-0173-z
Sparrow JR, Duncker T, Schuerch K, Paavo M, de Carvalho JRL (2020) Lessons learned from quantitative fundus autofluorescence. Prog Retin Eye Res 74:100774. https://doi.org/10.1016/j.preteyeres.2019.100774
doi: 10.1016/j.preteyeres.2019.100774
pubmed: 31472235
Deitch I, Ferenchak K, Miller JB (2021) Quantitative autofluorescence: review of current technical aspects and applications in chorioretinal disease. Semin Ophthalmol 36(4):346–350. https://doi.org/10.1080/08820538.2021.1908570
doi: 10.1080/08820538.2021.1908570
pubmed: 33818290
Chen S, Chang Y, Wu J (2001) The spatial distribution of macular pigment in humans. Curr Eye Res 23(6):422–434. https://doi.org/10.1076/ceyr.23.6.422.6963
doi: 10.1076/ceyr.23.6.422.6963
pubmed: 12045892
Jabs DA, Nussenblatt RB, Rosenbaum JT, Standardization of Uveitis Nomenclature Working Group (2005) Standardization of uveitis nomenclature for reporting clinical data Results of the First International Workshop. Am J Ophthalmol 140(3):509–16. https://doi.org/10.1016/j.ajo.2005.03.057
doi: 10.1016/j.ajo.2005.03.057
pubmed: 16196117
Rao NA, Wu GS (2000) Free radical mediated photoreceptor damage in uveitis. Prog Retin Eye Res 19(1):41–68. https://doi.org/10.1016/s1350-9462(99)00003-8
doi: 10.1016/s1350-9462(99)00003-8
pubmed: 10614680
Forrester JV, Huitinga I, Lumsden L, Dijkstra CD (1998) Marrow-derived activated macrophages are required during the effector phase of experimental autoimmune uveoretinitis in rats. Curr Eye Res 17(4):426–437. https://doi.org/10.1080/02713689808951224
doi: 10.1080/02713689808951224
pubmed: 9561835
Jiang H, Lumsden L, Forrester JV (1999) Macrophages and dendritic cells in IRBP-induced experimental autoimmune uveoretinitis in B10RIII mice. Invest Ophthalmol Vis Sci 40(13):3177–3185
pubmed: 10586940
Ito S, Wu G, Kimoto T, Hisatomi T, Ishibashi T, Rao NA (2004) Peroxynitrite-induced apoptosis in photoreceptor cells. Curr Eye Res 28(1):17–24. https://doi.org/10.1076/ceyr.28.1.17.23488
doi: 10.1076/ceyr.28.1.17.23488
pubmed: 14704910
Rajendram R, Saraswathy S, Rao NA (2007) Photoreceptor mitochondrial oxidative stress in early experimental autoimmune uveoretinitis. Br J Ophthalmol 91(4):531–537. https://doi.org/10.1136/bjo.2006.101576
doi: 10.1136/bjo.2006.101576
pubmed: 17035279
Kawali A, Pichi F, Avadhani K, Invernizzi A, Hashimoto Y, Mahendradas P (2017) Multimodal Imaging of the Normal Eye. Ocul Immunol Inflamm 25(5):721–731. https://doi.org/10.1080/09273948.2017.1375531
doi: 10.1080/09273948.2017.1375531
pubmed: 29083979
Pichi F, Srvivastava SK, Chexal S et al (2016) En face optical coherence tomography and optical coherence tomography angiography of multiple evanescent white dot syndrome: new insights into pathogenesis. Retina 36(Suppl 1):S178–S188. https://doi.org/10.1097/IAE.0000000000001255
doi: 10.1097/IAE.0000000000001255
pubmed: 28005676
Russell JF, Pichi F, Scott NL et al (2009) Masqueraders of multiple evanescent white dot syndrome (MEWDS). Int Ophthalmol 40(3):627–638. https://doi.org/10.1007/s10792-019-01223-4
doi: 10.1007/s10792-019-01223-4
Li D, Kishi S (2009) Restored photoreceptor outer segment damage in multiple evanescent white dot syndrome. Ophthalmology 116(4):762–770. https://doi.org/10.1016/j.ophtha.2008.12.060
doi: 10.1016/j.ophtha.2008.12.060
pubmed: 19344825
Furino C, Boscia F, Cardascia N et al (2009) Fundus autofluorescence and multiple evanescent white dot syndrome. Retina 29:60–63. https://doi.org/10.1097/IAE.0b013e31818c5e04
doi: 10.1097/IAE.0b013e31818c5e04
pubmed: 18936716
Gal-Or O, Sorenson JA, Gattoussi S et al (2019) Multiple evanescent white dot syndrome with subretinal deposits. Retin Cases Brief Rep 13:314–319. https://doi.org/10.1097/ICB.0000000000000602
doi: 10.1097/ICB.0000000000000602
pubmed: 28614139
Standardization of Uveitis Nomenclature (SUN) Working Group (2021) Classification criteria for acute posterior multifocal placoid pigment epitheliopathy. Am J Ophthalmol 228:174–181. https://doi.org/10.1016/j.ajo.2021.03.056
doi: 10.1016/j.ajo.2021.03.056
Klufas MA, Phasukkijwatana N, Iafe NA et al (2017) Optical coherence tomography angiography reveals choriocapillaris flow reduction in placoid chorioretinitis. Ophthalmol Retina 1(1):77–91. https://doi.org/10.1016/j.oret.2016.08.008
doi: 10.1016/j.oret.2016.08.008
pubmed: 31047399
Souka AAR, Hillenkamp J, Gora F, Gabel V, Framme C (2006) Correlation between optical coherence tomography and autofluorescence in acute posterior multifocal placoid pigment epitheliopathy. Graefe’s Arch Clin Exp Ophthalmol 244(10):1219–1223. https://doi.org/10.1007/s00417-006-0343-1
doi: 10.1007/s00417-006-0343-1
Lima LH, Greenberg JP, Greenstein VC et al (2012) Hyperautofluorescent ring in autoimmune retinopathy. Retina 32(7):1385–94. https://doi.org/10.1097/IAE.0b013e3182398107
doi: 10.1097/IAE.0b013e3182398107
pubmed: 22218149
pmcid: 4377132
Pepple KL, Cusick M, Jaffe GJ, Mruthyunjaya P (2013) SD-OCT and autofluorescence characteristics of autoimmune retinopathy. Br J Ophthalmol 97(2):139–44. https://doi.org/10.1136/bjophthalmol-2012-302524
doi: 10.1136/bjophthalmol-2012-302524
pubmed: 23221966
Canamary AM Jr, Takahashi WY, FerrazSallum JM (2018) Autoimmune retinopathy: a review. Int J Retina Vitreous. https://doi.org/10.1186/s40942-017-0104-9
doi: 10.1186/s40942-017-0104-9
pubmed: 29340169
pmcid: 5759752
Neri P, Pichi F (2022) Acute syphilitic posterior placoid chorioretinitis: when the great mimicker cannot pretend any more; new insight of an old acquaintance. J Ophthalmic Inflamm Infect. https://doi.org/10.1186/s12348-022-00286-2
doi: 10.1186/s12348-022-00286-2
pubmed: 35192047
pmcid: 8864036
Pichi F, Ciardella AP, Cunningham ET Jr et al (2014) Spectral domain optical coherence tomography findings in patients with acute syphilitic posterior placoid chorioretinopathy. Retina 34(2):373–384. https://doi.org/10.1097/IAE.0b013e3182993f11
doi: 10.1097/IAE.0b013e3182993f11
pubmed: 23860561
Pichi F, Dolz-Marco R, Francis JH et al (2022) Advanced OCT analysis of biopsy-proven vitreoretinal lymphoma. Am J Ophthalmol 238:16–26. https://doi.org/10.1016/j.ajo.2021.11.023
doi: 10.1016/j.ajo.2021.11.023
pubmed: 34843686
Casady M, Faia L, Nazemzadeh M, Nussenblatt R, Chan CC, Sen HN (2014) Fundus autofluorescence patterns in primary intraocular lymphoma. Retina 34(2):366–372. https://doi.org/10.1097/IAE.0b013e31829977fa
doi: 10.1097/IAE.0b013e31829977fa
pubmed: 23958842
Ishida T, Ohno-Matsui K, Kaneko Y et al (2010) Fundus autofluorescence patterns in eyes with primary intraocular lymphoma. Retina 30(1):23–32. https://doi.org/10.1097/IAE.0b013e3181b408a2
doi: 10.1097/IAE.0b013e3181b408a2
pubmed: 19834356
Shifera AS, Pennesi ME, Yang P, Lin P (2017) Ultra-wide-field fundus autofluorescence findings in patients with acute zonal occult outer retinopathy. Retina 37(6):1104–1119. https://doi.org/10.1097/IAE.0000000000001311
doi: 10.1097/IAE.0000000000001311
pubmed: 27755372
pmcid: 5393961
Herbort CP Jr, Arapi I, Papasavvas I, Mantovani A, Jeannin B (2021) Acute Zonal Occult Outer Retinopathy (AZOOR) results from a clinicopathological mechanism different from choriocapillaritis diseases: a multimodal imaging analysis. Diagnostics (Basel) 29(7):1184. https://doi.org/10.3390/diagnostics11071184
doi: 10.3390/diagnostics11071184
Yeh S, Forooghian F, Wong WT et al (2010) Fundus autofluorescence imaging of the white dot syndromes. Arch Ophthalmol 128(1):46–56. https://doi.org/10.1001/archophthalmol.2009.368
doi: 10.1001/archophthalmol.2009.368
pubmed: 20065216
pmcid: 3025103
Standardization of Uveitis Nomenclature (SUN) Working Group (2021) Classification criteria for multifocal choroiditis with panuveitis. Am J Ophthalmol 228:152–158. https://doi.org/10.1016/j.ajo.2021.03.043
doi: 10.1016/j.ajo.2021.03.043
Standardization of Uveitis Nomenclature (SUN) Working Group (2021) Classification criteria for punctate inner choroiditis. Am J Ophthalmol 228:275–280. https://doi.org/10.1016/j.ajo.2021.03.046
doi: 10.1016/j.ajo.2021.03.046
Matsumoto Y, Haen SP, Spaide RF (2007) The white dot syndromes. Compr Ophthalmol Update 8(4):179–200
pubmed: 17999832
Haen SP, Spaide RF (2008) Fundus autofluorescence in multifocal choroiditis and panuveitis. Am J Ophthalmol 145(5):847–853. https://doi.org/10.1016/j.ajo.2008.01.008
doi: 10.1016/j.ajo.2008.01.008
pubmed: 18329623
Shakoor A, Vitale AT (2012) Imaging in the diagnosis and management of multifocal choroiditis and punctate inner choroidopathy. Int Ophthalmol Clin 52(4):243–256. https://doi.org/10.1097/IIO.0b013e318265fb51
doi: 10.1097/IIO.0b013e318265fb51
pubmed: 22954947
Turkcuoglu P, Chang PY, Rentiya ZS et al (2011) Mycophenolate mofetil and fundus autofluorescence in the management of recurrent punctate inner choroidopathy. Ocul Immunol Inflamm 19(4):286–292. https://doi.org/10.3109/09273948.2011.580072
doi: 10.3109/09273948.2011.580072
pubmed: 21770809
Munk MR, Jung JJ, Biggee K et al (2015) Idiopathic multifocal choroiditis/punctate inner choroidopathy with acute photoreceptor loss or dysfunction out of proportion to clinically visible lesions. Retina 35:334–343. https://doi.org/10.1097/IAE.0000000000000370
doi: 10.1097/IAE.0000000000000370
pubmed: 25322466
pmcid: 4304934
Standardization of Uveitis Nomenclature (SUN) Working Group (2021) Classification criteria for serpiginous choroiditis. Am J Ophthalmol 228:126–133. https://doi.org/10.1016/j.ajo.2021.03.038
doi: 10.1016/j.ajo.2021.03.038
Gupta A, Bansal R, Gupta V et al (2012) Fundus autofluorescence in serpiginouslike choroiditis. Retina 32:814–825. https://doi.org/10.1097/IAE.0b013e3182278c41
doi: 10.1097/IAE.0b013e3182278c41
pubmed: 22080913
Jones BE, Jampol LM, Yannuzzi LA, Tittl M, Johnson MW, Han DP, Davis JL, Williams DF (2000) Relentless placoid chorioretinitis: A new entity or an unusual variant of serpiginous chorioretinitis? Arch Ophthalmol 118(7):931–938
pubmed: 10900106
Veronese C, Marcheggiani EB, Tassi F, Pichi F, Morara M, Ciardella AP (2014) Early autofluorescence findings of relentless placoid chorioretinitis. Retina 34(3):625–627. https://doi.org/10.1097/IAE.0b013e3182a487d5
doi: 10.1097/IAE.0b013e3182a487d5
pubmed: 24008837
Bansal R, Kulkarni P, Gupta A, Gupta V, Dogra MR (2011) High-resolution spectral domain optical coherence tomography and fundus autofluorescence correlation in tubercular serpiginouslike choroiditis. J Ophthalmic Inflamm Infect 1(4):157–163. https://doi.org/10.1007/s12348-011-0037-7
doi: 10.1007/s12348-011-0037-7
pubmed: 21847595
pmcid: 3223337
Standardization of Uveitis Nomenclature (SUN) Working Group (2021) Classification criteria for toxoplasmic retinitis. Am J Ophthalmol 228:134–141. https://doi.org/10.1016/j.ajo.2021.03.042
doi: 10.1016/j.ajo.2021.03.042
Pichi F, Veronese C, Lembo A, Invernizzi A, Mantovani A, Herbort CP, Cunningham ET Jr, Morara M, Ricci F, Neri P (2017) New appraisals of Kyrieleis plaques: a multimodal imaging study. Br J Ophthalmol 101(3):316–321. https://doi.org/10.1136/bjophthalmol-2015-308246
doi: 10.1136/bjophthalmol-2015-308246
pubmed: 27267451
Mathis T, Delaunay B, Favard C, Denis P, Kodjikian L (2020) Hyperautofluorescent spots in acute ocular toxoplasmosis: a new indicator of outer retinal inflammation. Retina 40(12):2396–2402. https://doi.org/10.1097/IAE.0000000000002759
doi: 10.1097/IAE.0000000000002759
pubmed: 31923122
Zicarelli F, Pichi F, Parrulli S et al (2022) Acute posterior ocular toxoplasmosis: an optical coherence tomography angiography and dye angiography study. Ocul Immunol Inflamm 30(3):541–545. https://doi.org/10.1080/09273948.2021.1977831
doi: 10.1080/09273948.2021.1977831
pubmed: 34637664
Standardization of Uveitis Nomenclature (SUN) Working Group (2021) Classification criteria for birdshot chorioretinitis. Am J Ophthalmol 228:65–71. https://doi.org/10.1016/j.ajo.2021.03.059
doi: 10.1016/j.ajo.2021.03.059
Comander J, Loewenstein J, Sobrin L (2011) Diagnostic testing and disease monitoring in birdshot chorioretinopathy. Seminars in Ophthalmol 26(4–5):329–336. https://doi.org/10.3109/08820538.2011.588661
doi: 10.3109/08820538.2011.588661
Koizumi H, Pozzoni MC, Spaide RF (2008) Fundus autofluorescence in birdshot chorioretinopathy. Ophthalmology 115(5):e15-20. https://doi.org/10.1016/j.ophtha.2008.01.025
doi: 10.1016/j.ophtha.2008.01.025
pubmed: 18378316
Giuliari G, Hinkle DM, Foster CS (2009) The spectrum of fundus autofluorescence findings in birdshot chorioretinopathy. J Ophthalmol 2009:567693. https://doi.org/10.1155/2009/567693
doi: 10.1155/2009/567693
pubmed: 20339461
Seidensticker F, Neubauer AS, Wasfy T et al (2011) Wide-field fundus autofluorescence corresponds to visual fields in chorioretinitis patients. Clin Ophthalmol 5:1667–1671. https://doi.org/10.2147/OPTH.S26224
doi: 10.2147/OPTH.S26224
pubmed: 22174575
pmcid: 3236712
Tomkins-Netzer O, Taylor SRJ, Lightman S (2014) Long-term clinical and anatomic outcome of birdshot chorioretinopathy. JAMA Ophthalmol 132(1):57–62. https://doi.org/10.1001/jamaophthalmol.2013.6235
doi: 10.1001/jamaophthalmol.2013.6235
pubmed: 24336967
Gass JD, Gieser RG, Wilkinson CP, Beahm DE, Pautler SE (1990) Bilateral diffuse uveal melanocytic proliferation in patients with occult carcinoma. Arch Ophthalmol 108(4):527–533. https://doi.org/10.1001/archopht.1990.01070060075053
doi: 10.1001/archopht.1990.01070060075053
pubmed: 2322154
Shiraki A, Winegarner A, Hashida N, Nishi O, Nishi Y, Maruyama K, Nishida K (2018) Diagnostic evaluation of optical coherence tomography angiography and fundus autofluorescence in bilateral diffuse uveal melanocytic proliferation. Am J Ophthalmol Case Rep 11:32–34. https://doi.org/10.1016/j.ajoc.2018.04.014
doi: 10.1016/j.ajoc.2018.04.014
pubmed: 30128363
pmcid: 6097180
Naysan J, Pang CE, Klein RW, Freund KB (2016) Multimodal imaging of bilateral diffuse uveal melanocytic proliferation associated with an iris mass lesion. Int J Retina Vitreous 16(2):13. https://doi.org/10.1186/s40942-016-0038-7
doi: 10.1186/s40942-016-0038-7