Peak Oxygen Consumption (V̇O 2peak ) Recovery Delay in a Pediatric Fontan Population.
Journal
Medicine and science in sports and exercise
ISSN: 1530-0315
Titre abrégé: Med Sci Sports Exerc
Pays: United States
ID NLM: 8005433
Informations de publication
Date de publication:
01 11 2023
01 11 2023
Historique:
medline:
9
11
2023
pubmed:
7
7
2023
entrez:
7
7
2023
Statut:
ppublish
Résumé
The purpose of this study is to identify predictors and correlates of VO2RD in youth with Fontan. Cardiopulmonary exercise test data was used from a single center, cross-sectional study of children and adolescents (age, 8-21 yr) with Fontan physiology. The VO2RD was determined using time (s) to <90% of V̇O 2peak and categorized as "low" (≤10 s) or "high" (≥10 s). t Tests and χ 2 analysis were used to compare continuous and categorical variables, respectively. The analysis sample included 30 adolescents with Fontan physiology (age, 14.2 ± 2.4 yr; 67% male) with either right ventricular (RV) dominant (40%) or co/left ventricular (Co/LV) dominant (60%) systemic ventricular morphology. There were no differences in V̇O 2peak between the high and low VO2RD groups (high = 1.3 ± 0.4 L·min -1 ; low = 1.3 ± 0.3 L·min -1 ; P = 0.97). VO2RD in participants with RV dominance was significantly greater than in patients with Co/LV dominance (RV = 23.8 ± 15.8 s; Co/LV = 11.8 ± 16.1 s; P = 0.03). V̇O 2peak was not correlated with VO2RD when analyzed as high/low VO2RD groups. However, morphology of the systemic single ventricle (RV vs Co/LV) may be related to rate of recovery in V̇O 2 after a peak cardiopulmonary exercise test.
Identifiants
pubmed: 37418236
doi: 10.1249/MSS.0000000000003247
pii: 00005768-202311000-00003
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
1961-1967Subventions
Organisme : NHLBI NIH HHS
ID : K23 HL159325
Pays : United States
Informations de copyright
Copyright © 2023 by the American College of Sports Medicine.
Références
Oster ME, Knight JH, Suthar D, Amin O, Kochilas LK. Long-term outcomes in single-ventricle congenital heart disease. Circulation . 2018;138(23):2718–20.
Atz AM, Zak V, Mahony L, et al. Longitudinal outcomes of patients with single ventricle after the Fontan procedure. J Am Coll Cardiol . 2017;69(22):2735–44.
McCracken C, Spector LG, Menk JS, et al. Mortality following pediatric congenital heart surgery: an analysis of the causes of death derived from the national death index. J Am Heart Assoc . 2018;7(22):e010624.
Bangsbo J, Gollnick PD, Graham TE, et al. Anaerobic energy production and O2 deficit-debt relationship during exhaustive exercise in humans. J Physiol . 1990;422(1):539–59.
Khairy P, Poirier N, Mercier LA. Univentricular heart. Circulation . 2007;115(6):800–12.
Downing TE, Allen KY, Glatz AC, et al. Long-term survival after the Fontan operation: twenty years of experience at a single center. J Thorac Cardiovasc Surg . 2017;154(1):243–53.e2.
Canter CE, Shaddy RE, Bernstein D, et al. Indications for heart transplantation in pediatric heart disease: a scientific statement from the American Heart Association Council on cardiovascular disease in the young; the councils on clinical cardiology, cardiovascular nursing, and cardiovascular surgery and anesthesia; and the quality of care and outcomes research interdisciplinary working group. Circulation . 2007;115(5):658–76.
Paridon SM, Mitchell PD, Colan SD, et al. A cross-sectional study of exercise performance during the first 2 decades of life after the Fontan operation. J Am Coll Cardiol . 2008;52(2):99–107.
Diller GP, Giardini A, Dimopoulos K, et al. Predictors of morbidity and mortality in contemporary Fontan patients: results from a multicenter study including cardiopulmonary exercise testing in 321 patients. Eur Heart J . 2010;31(24):3073–83.
Fernandes SM, Alexander ME, Graham DA, et al. Exercise testing identifies patients at increased risk for morbidity and mortality following Fontan surgery. Congenit Heart Dis . 2011;6(4):294–303.
Inuzuka R, Diller GP, Borgia F, et al. Comprehensive use of cardiopulmonary exercise testing identifies adults with congenital heart disease at increased mortality risk in the medium term. Circulation . 2012;125(2):250–9.
Shafer KM, Opotowsky AR, Rhodes J. Exercise testing and spirometry as predictors of mortality in congenital heart disease: contrasting Fontan physiology with repaired tetralogy of Fallot. Congenit Heart Dis . 2018;13(6):903–10.
Khairy P, Fernandes SM, Mayer JE Jr, et al. Long-term survival, modes of death, and predictors of mortality in patients with Fontan surgery. Circulation . 2008;117(1):85–92.
Hebert A, Jensen AS, Mikkelsen UR, et al. Hemodynamic causes of exercise intolerance in Fontan patients. Int J Cardiol . 2014;175(3):478–83.
Giardini A, Hager A, Pace Napoleone C, Picchio FM. Natural history of exercise capacity after the Fontan operation: a longitudinal study. Ann Thorac Surg . 2008;85(3):818–21.
Ohuchi H, Yasuda K, Hasegawa S, et al. Influence of ventricular morphology on aerobic exercise capacity in patients after the Fontan operation. J Am Coll Cardiol . 2001;37(7):1967–74.
Goldberg DJ, Avitabile CM, McBride MG, Paridon SM. Exercise capacity in the Fontan circulation. Cardiol Young . 2013;23(6):824–30.
Durongpisitkul K, Driscoll DJ, Mahoney DW, et al. Cardiorespiratory response to exercise after modified Fontan operation: determinants of performance. J Am Coll Cardiol . 1997;29(4):785–90.
Akagi T, Benson LN, Gilday DL, et al. Influence of ventricular morphology on diastolic filling performance in double-inlet ventricle after the Fontan procedure. J Am Coll Cardiol . 1993;22(7):1948–52.
Drakonakis AM, Halloran K. Oxygen consumption during recovery from exercise in children with congenital heart disease. Am J Dis Child . 1974;128(5):651–6.
Zanconato S, Baraldi E, Santuz P, et al. Gas exchange during exercise in obese children. Eur J Pediatr . 1989;148(7):614–7.
Singh TP, Alexander ME, Gauvreau K, Curran T, Rhodes Y, Rhodes J. Recovery of oxygen consumption after maximal exercise in children. Med Sci Sports Exerc . 2011;43(4):555–9.
Cohen-Solal A, Laperche T, Morvan D, Geneves M, Caviezel B, Gourgon R. Prolonged kinetics of recovery of oxygen consumption after maximal graded exercise in patients with chronic heart failure. Analysis with gas exchange measurements and NMR spectroscopy. Circulation . 1995;91(12):2924–32.
Bailey CS, Wooster LT, Buswell M, et al. Post-exercise oxygen uptake recovery delay: a novel index of impaired cardiac reserve capacity in heart failure. JACC Heart Fail . 2018;6(4):329–39.
Ohuchi H, Hamamichi Y, Hayashi T, et al. Post-exercise heart rate, blood pressure and oxygen uptake dynamics in pediatric patients with Fontan circulation comparison with patients after right ventricular outflow tract reconstruction. Int J Cardiol . 2005;101(1):129–36.
Troutman WB, Barstow TJ, Galindo AJ, Cooper DM. Abnormal dynamic cardiorespiratory responses to exercise in pediatric patients after Fontan procedure. J Am Coll Cardiol . 1998;31(3):668–73.
Mertens L, Reybrouck T, Eyskens B, Daenen W, Gewillig M. Slow kinetics of oxygen uptake in patients with a Fontan-type circulation. Pediatr Exerc Sci . 2003;15(2):146–55.
Goudar S, Forsha D, White DA, Sherman A, Shirali G. Single ventricular strain measures correlate with peak oxygen consumption in children and adolescents with Fontan circulation. Cardiol Young . 2023;33(7):1136–42.
Goldberg DJ, Zak V, Goldstein BH, et al. Results of the FUEL trial. Circulation . 2020;141(8):641–51.
Kuczmarski RJ, Ogden CL, Grummer-Strawn LM, et al. CDC growth charts: United States. Adv Data . 2000;314:1–27.
James FW, Kaplan S, Glueck CJ, Tsay JY, Knight MJ, Sarwar CJ. Responses of normal children and young adults to controlled bicycle exercise. Circulation . 1980;61(5):902–12.
Cooper DM, Weiler-Ravell D. Gas exchange response to exercise in children. Am Rev Respir Dis . 1984;129(2 Pt 2):S47–8.
Ohuchi H, Ohashi H, Park J, Hayashi J, Miyazaki A, Echigo S. Abnormal postexercise cardiovascular recovery and its determinants in patients after right ventricular outflow tract reconstruction. Circulation . 2002;106(22):2819–26.
Coomans I, De Kinder S, Van Belleghem H, et al. Analysis of the recovery phase after maximal exercise in children with repaired tetralogy of Fallot and the relationship with ventricular function. PLoS One . 2020;15(12):e0244312.
Stevens DM, Oades PJ, Armstrong N, Williams CA. Early oxygen uptake recovery following exercise testing in children with chronic chest diseases. Pediatr Pulmonol . 2009;44(5):480–8.
Sano T, Ogawa M, Taniguchi K, et al. Assessment of ventricular contractile state and function in patients with univentricular heart. Circulation . 1989;79(6):1247–56.
Courtois M, Barzilai B, Gutierrez F, Ludbrook PA. Characterization of regional diastolic pressure gradients in the right ventricle. Circulation . 1990;82(4):1413–23.
Piiper J, Spiller P. Repayment of O 2 debt and resynthesis of high-energy phosphates in gastrocnemius muscle of the dog. J Appl Physiol . 1970;28(5):657–62.
Margaria R, Cerretelli P, Diprampero PE, Massari C, Torelli G. Kinetics and mechanism of oxygen debt contraction in man. J Appl Physiol . 1963;18:371–7.
Lakatta EG, Chantler PD. Payments for debts associated with exercise can become higher as we age and limit exercise capacity. J Am Coll Cardiol . 2006;47(5):1058–9.
Woo JS, Derleth C, Stratton JR, Levy WC. The influence of age, gender, and training on exercise efficiency. J Am Coll Cardiol . 2006;47(5):1049–57.
Reybrouck T, Defoor J, Bijnens B, Mertens L, Gewillig M. Influence of work rate on the determinants of oxygen deficit during short-term submaximal exercise: implications for clinical research. Clin Physiol Funct Imaging . 2003;23(1):42–9.
Reybrouck T, Gewillig M. Assessment of oxygen deficit during exercise in obese children and adolescents. Pediatr Exerc Sci . 2005;17(3):291–300.
Moalla W, Dupont G, Costes F, Gauthier R, Maingourd Y, Ahmaidi S. Performance and muscle oxygenation during isometric exercise and recovery in children with congenital heart diseases. Int J Sports Med . 2006;27(11):864–9.