Expression pattern of lncRNAs in pituitary adenomas.

Humans Pituitary Neoplasms / pathology RNA, Long Noncoding / genetics Adenoma / pathology
ARHGAP5-AS1 ATP6V0E2-AS1 EPB41L4A-AS1 FGD5-AS1 Pituitary adenoma WWC2-AS2

Journal

Pathology, research and practice
ISSN: 1618-0631
Titre abrégé: Pathol Res Pract
Pays: Germany
ID NLM: 7806109

Informations de publication

Date de publication:
Aug 2023
Historique:
received: 15 06 2023
revised: 01 07 2023
accepted: 02 07 2023
medline: 16 8 2023
pubmed: 8 7 2023
entrez: 7 7 2023
Statut: ppublish

Résumé

Non-functioning pituitary adenomas (NFPAs) are a group of pituitary tumors lacking manifestations linked to high hormone production, such as acromegaly and Cushing's syndrome. NFPA carcinogenesis depends on several molecular players. Long non-coding RNAs (lncRNAs) are a class of molecular players whose role in tumorigenesis has just recently been recognized. In the current study, we appraised expressions of 5 lncRNAs, namely FGD5-AS1, ATP6V0E2-AS1, ARHGAP5-AS1, WWC2-AS2 and EPB41L4A-AS1 in NFPAs versus their corresponding non-tumoral samples. Expressions of ATP6V0E2-AS1, EPB41L4A-AS1, FGD5-AS1 and WWC2-AS2 were significantly increased in NFPA samples compared with adjacent non-tumoral samples (P values = 0.037, 0.007, 0.008 and 0.03, respectively). However, expression of ARHGAP5-AS1 was not different between NFPA samples and controls (P value = 0.62). EPB41L4A-AS1 and FGD5-AS1 could discriminate between NFPA samples and adjacent non-tumoral samples (P values = 0.03 and 0.04, respectively). However, the AUC values were not appropriate. There was a significant positive association between age of NFPA patients and invasiveness of NFPA (χ

Identifiants

DOI: 10.1016/j.prp.2023.154668 PMID: 37418994
pubmed: 37418994
pii: S0344-0338(23)00368-0
doi: 10.1016/j.prp.2023.154668
pii:
doi:

Substances chimiques

RNA, Long Noncoding 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

154668

Informations de copyright

Copyright © 2023 The Authors. Published by Elsevier GmbH.. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Competing Interest The authors declare they have no conflict of interest.

Auteurs

Soudeh Ghafouri-Fard (S)

Men's Health and Reproductive Health Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Islamic Republic of Iran.

Maryam Khaledabadi (M)

Department of Operating Room Technology, School of Allied Medical Sciences, International Campus, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran.

Ghazal Najafi (G)

Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Islamic Republic of Iran.

Arash Safarzadeh (A)

Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Islamic Republic of Iran.

Bashdar Mahmud Hussen (BM)

Department of Clinical Analysis, College of Pharmacy, Hawler Medical University, Kurdistan Region, Islamic Republic of Iran.

Solat Eslami (S)

Dietary Supplements and Probiotic Research Center, Alborz University of Medical Sciences, Karaj, Islamic Republic of Iran; Department of Medical Biotechnology, School of Medicine, Alborz University of Medical Sciences, Karaj, Islamic Republic of Iran.

Guive Sharifi (G)

Skull Base Research Center, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Islamic Republic of Iran.

Mohammad Taheri (M)

Institute of Human Genetics, Jena University Hospital, Jena, Germany; Urology and Nephrology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Islamic Republic of Iran. Electronic address: mohammad.taheri@uni-jena.de.

Nader Akbari Dilmaghani (NA)

Skull Base Research Center, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Islamic Republic of Iran. Electronic address: nadakbari@sbmu.ac.ir.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Expression pattern of lncRNAs in pituitary adenomas.
questionsmedicales.fr › Maladies endocriniennes › Maladies de l'hypophyse › Tumeurs de l'hypophyse › Expression pattern of lncRNAs in pituitary adenomas.
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN non traduit › ARN long non codant › Expression pattern of lncRNAs in pituitary adenomas.
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Tumeurs épithéliales épidermoïdes et glandulaires › Adénomes › Expression pattern of lncRNAs in pituitary adenomas.