Oral administration of ovalbumin protects mice from concanavalin A-induced hepatitis through suppression of interferon-gamma responses.

Mice Animals Interferon-gamma Ovalbumin Mice, Transgenic Concanavalin A Antigens Hepatitis Administration, Oral Mice, Inbred BALB C
Hepatitis Interferon-gamma Interleukin-4 Oral tolerance

Journal

Biochemical and biophysical research communications
ISSN: 1090-2104
Titre abrégé: Biochem Biophys Res Commun
Pays: United States
ID NLM: 0372516

Informations de publication

Date de publication:
24 09 2023
Historique:
received: 27 06 2023
accepted: 29 06 2023
medline: 15 8 2023
pubmed: 8 7 2023
entrez: 7 7 2023
Statut: ppublish

Résumé

The liver is a tolerogenic organ that exhibits hypo-responsiveness to antigens circulating in the portal vein. Antigens that are orally administered at high doses reach the liver. In our previous study, we demonstrated that administering ovalbumin (OVA) orally at high doses generates unique CD4

Identifiants

DOI: 10.1016/j.bbrc.2023.06.091 PMID: 37419032
pubmed: 37419032
pii: S0006-291X(23)00846-X
doi: 10.1016/j.bbrc.2023.06.091
pii:
doi:

Substances chimiques

Interferon-gamma 82115-62-6
Ovalbumin 9006-59-1
Concanavalin A 11028-71-0
Antigens 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

117-123

Informations de copyright

Copyright © 2023 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Auteurs

Tomohiro Watanabe (T)

Department of Gastroenterology and Hepatology, Kindai University Faculty of Medicine, 377-2 Ohno-Higashi, Osaka-Sayama, Osaka, 589-8511, Japan; Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, 54 Shogoin Kawahara-cho, Sakyo-Ku, Kyoto, 606-8507, Kyoto, Japan. Electronic address: tomohiro@med.kindai.ac.jp.

Kosuke Minaga (K)

Department of Gastroenterology and Hepatology, Kindai University Faculty of Medicine, 377-2 Ohno-Higashi, Osaka-Sayama, Osaka, 589-8511, Japan.

Hajime Honjo (H)

Department of Gastroenterology and Hepatology, Kindai University Faculty of Medicine, 377-2 Ohno-Higashi, Osaka-Sayama, Osaka, 589-8511, Japan.

Masatoshi Kudo (M)

Department of Gastroenterology and Hepatology, Kindai University Faculty of Medicine, 377-2 Ohno-Higashi, Osaka-Sayama, Osaka, 589-8511, Japan.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Oral administration of ovalbumin protects mice...
questionsmedicales.fr › Eucaryotes › Animaux › Oral administration of ovalbumin protects mice...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Lymphokines › Facteurs d'activation des macrophages › Interféron gamma › Oral administration of ovalbumin protects mice...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Ovalbumine › Oral administration of ovalbumin protects mice...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Oral administration of ovalbumin protects mice...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines végétales › Lectines végétales › Concanavaline A › Oral administration of ovalbumin protects mice...
questionsmedicales.fr › Facteurs biologiques › Antigènes › Oral administration of ovalbumin protects mice...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies du foie › Hépatite › Oral administration of ovalbumin protects mice...
questionsmedicales.fr › Thérapeutique › Traitement médicamenteux › Voies d'administration de substances chimiques et des médicaments › Administration par voie orale › Oral administration of ovalbumin protects mice...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée BALB C › Oral administration of ovalbumin protects mice...