Evolution of immune and stromal cell states and ecotypes during gastric adenocarcinoma progression.
Cancer-associated fibroblast
Chronic Atrophic Gastritis
Ecotype
Gastric Adenocarcinoma
Immune-Stroma Crosstalk
Intestinal Metaplasia
Peritoneal Carcinomatosis
Single Cell RNA Sequencing
Syndecan 2
Tumor Microenvironment
Journal
Cancer cell
ISSN: 1878-3686
Titre abrégé: Cancer Cell
Pays: United States
ID NLM: 101130617
Informations de publication
Date de publication:
14 08 2023
14 08 2023
Historique:
received:
13
11
2022
revised:
10
04
2023
accepted:
12
06
2023
pmc-release:
14
08
2024
medline:
17
8
2023
pubmed:
8
7
2023
entrez:
7
7
2023
Statut:
ppublish
Résumé
Understanding tumor microenvironment (TME) reprogramming in gastric adenocarcinoma (GAC) progression may uncover novel therapeutic targets. Here, we performed single-cell profiling of precancerous lesions, localized and metastatic GACs, identifying alterations in TME cell states and compositions as GAC progresses. Abundant IgA
Identifiants
pubmed: 37419119
pii: S1535-6108(23)00215-5
doi: 10.1016/j.ccell.2023.06.005
pmc: PMC10528152
mid: NIHMS1911108
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
1407-1426.e9Subventions
Organisme : NCI NIH HHS
ID : P30 CA016672
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA266280
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA269685
Pays : United States
Informations de copyright
Copyright © 2023 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests The authors declare no competing interests.
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