Alcohol and drug use severity are independently associated with antiretroviral adherence in the current treatment era.

ART Substance use adherence alcohol antiretroviral therapy methamphetamine

Journal

AIDS care
ISSN: 1360-0451
Titre abrégé: AIDS Care
Pays: England
ID NLM: 8915313

Informations de publication

Date de publication:
07 Jul 2023
Historique:
medline: 8 7 2023
pubmed: 8 7 2023
entrez: 7 7 2023
Statut: aheadofprint

Résumé

Substance use in people with HIV (PWH) negatively impacts antiretroviral therapy (ART) adherence. However, less is known about this in the current treatment era and the impact of specific substances or severity of substance use. We examined the associations of alcohol, marijuana, and illicit drug use (methamphetamine/crystal, cocaine/crack, illicit opioids/heroin) and their severity of use with adherence using multivariable linear regression in adult PWH in care between 2016 and 2020 at 8 sites across the US. PWH completed assessments of alcohol use severity (AUDIT-C), drug use severity (modified ASSIST), and ART adherence (visual analogue scale). Among 9400 PWH, 16% reported current hazardous alcohol use, 31% current marijuana use, and 15% current use of ≥1 illicit drugs. In multivariable analysis, current methamphetamine/crystal use, particularly common among men who had sex with men, was associated with 10.1% lower mean ART adherence (

Identifiants

DOI: 10.1080/09540121.2023.2223899 PMID: 37419138
pubmed: 37419138
doi: 10.1080/09540121.2023.2223899
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

1-13

Subventions

Organisme : NIMH NIH HHS
ID : P30 MH133399
Pays : United States

Auteurs

J Ma (J)

Department of Medicine, University of Washington, Seattle, WA, USA.
ORCID: 0000-0002-6849-3206

B Luu (B)

Department of Medicine, University of Toronto, Toronto, Canada.

S A Ruderman (SA)

Department of Medicine, University of Washington, Seattle, WA, USA.

B M Whitney (BM)

Department of Medicine, University of Washington, Seattle, WA, USA.

J O Merrill (JO)

Department of Medicine, University of Washington, Seattle, WA, USA.

L S Mixson (LS)

Department of Medicine, University of Washington, Seattle, WA, USA.

R M Nance (RM)

Department of Medicine, University of Washington, Seattle, WA, USA.

L N Drumright (LN)

Department of Medicine, University of Washington, Seattle, WA, USA.
Department of Biobehavioral Nursing and Health Informatics, University of Washington, Seattle, WA, USA.

A W Hahn (AW)

Department of Medicine, University of Washington, Seattle, WA, USA.

R J Fredericksen (RJ)

Department of Medicine, University of Washington, Seattle, WA, USA.

G Chander (G)

Department of Medicine, University of Washington, Seattle, WA, USA.

B Lau (B)

Department of Epidemiology, Johns Hopkins University, Baltimore, MD, USA.

M E McCaul (ME)

Department of Psychiatry, Johns Hopkins University, Baltimore, MD, USA.

S Safren (S)

Department of Psychology, University of Miami, Miami, FL, USA.
ORCID: 0000-0002-0121-0806

C O'Cleirigh (C)

Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA.
Department of Psychology, Harvard Medical School, Boston, MA, USA.
ORCID: 0000-0002-5639-5043

K Cropsey (K)

Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.

K H Mayer (KH)

Department of Medicine, Harvard Medical School, Boston, MA, USA.
The Fenway Institute, Boston, MA, USA.
ORCID: 0000-0001-7460-733X

W C Mathews (WC)

Department of Medicine, University of California, San Diego, CA, USA.

R D Moore (RD)

Department of Medicine, Johns Hopkins University, Baltimore, MD, USA.

S Napravnik (S)

Department of Medicine, University of North Carolina, Chapel Hill, NC, USA.
Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA.

K Christopoulos (K)

Department of Medicine, University of California, San Francisco, CA, USA.

A Willig (A)

Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.

J M Jacobson (JM)

Department of Medicine, Case Western Reserve University, Cleveland, OH, USA.

A Webel (A)

Department of Child, Family, and Population Health Nursing, Unviersity of Washington, Seattle, WA, USA.

G Burkholder (G)

Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.

M J Mugavero (MJ)

Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.

M S Saag (MS)

Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.

M M Kitahata (MM)

Department of Medicine, University of Washington, Seattle, WA, USA.

H M Crane (HM)

Department of Medicine, University of Washington, Seattle, WA, USA.

J A C Delaney (JAC)

Department of Medicine, University of Washington, Seattle, WA, USA.
College of Pharmacy, University of Manitoba, Winnipeg, Canada.

Classifications MeSH