Indoor (residential) and ambient particulate matter associations with urinary oxidative stress biomarkers in a COPD cohort.
8-Hydroxy-2′-deoxyguanosine
Air pollution
Black carbon
Chronic obstructive pulmonary disease
Malondialdehyde
PM(2.5)
Journal
The Science of the total environment
ISSN: 1879-1026
Titre abrégé: Sci Total Environ
Pays: Netherlands
ID NLM: 0330500
Informations de publication
Date de publication:
01 Nov 2023
01 Nov 2023
Historique:
received:
11
04
2023
revised:
18
06
2023
accepted:
04
07
2023
pmc-release:
01
11
2024
medline:
25
9
2023
pubmed:
8
7
2023
entrez:
7
7
2023
Statut:
ppublish
Résumé
Oxidative stress contributes to chronic obstructive pulmonary disease (COPD) pathophysiology. Associations between indoor (residential) exposure to particulate matter ≤2.5 μm in diameter (PM Between 2012 and 2017, 140 patients with COPD completed in-home air sampling over one week intervals, followed by collection of urine samples to measure oxidative stress biomarkers, malondialdehyde (MDA), a marker of lipid peroxidation, and 8-hydroxy-2' -deoxyguanosine (8-OHdG), a marker of oxidative DNA damage. Ambient (central site) BC and PM There were positive associations (% increase per IQR; 95 % CI) of directly measured indoor BC with total MDA (6.96; 1.54, 12.69) and 8-OHdG (4.18; -0.67, 9.27), and similar associations with both indoor BC of outdoor origin and ambient BC. There were no associations with directly measured indoor PM In homes with few indoor combustion sources, directly measured indoor BC, estimates of indoor BC and PM
Identifiants
pubmed: 37419349
pii: S0048-9697(23)03975-X
doi: 10.1016/j.scitotenv.2023.165352
pmc: PMC10529440
mid: NIHMS1917314
pii:
doi:
Substances chimiques
Particulate Matter
0
Air Pollutants
0
Biomarkers
0
8-Hydroxy-2'-Deoxyguanosine
88847-89-6
Soot
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
165352Subventions
Organisme : NIEHS NIH HHS
ID : P30 ES000002
Pays : United States
Organisme : NIEHS NIH HHS
ID : R01 ES019853
Pays : United States
Organisme : NIEHS NIH HHS
ID : R21 ES029637
Pays : United States
Informations de copyright
Copyright © 2023 Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Eric Garshick reports financial support was provided by National Institute of Environmental Health Sciences.
Références
Environ Int. 2013 Oct;60:112-22
pubmed: 24041735
Nephrol Dial Transplant. 2009 Aug;24(8):2524-9
pubmed: 19264746
Res Rep Health Eff Inst. 2013 Feb;(174):5-174
pubmed: 23646463
Thorax. 2014 Jul;69(7):660-5
pubmed: 24706041
Environ Res. 2020 Dec;191:110105
pubmed: 32835677
J Expo Sci Environ Epidemiol. 2018 Mar;28(2):125-130
pubmed: 29064481
Environ Health Perspect. 2005 Apr;113(4):499-503
pubmed: 15811822
J Am Heart Assoc. 2016 Apr 28;5(5):
pubmed: 27126478
J Thorac Dis. 2018 May;10(5):3088-3097
pubmed: 29997978
J Expo Sci Environ Epidemiol. 2012 Mar-Apr;22(2):161-72
pubmed: 22086209
Environ Res. 2022 Jun;209:112802
pubmed: 35101396
J Air Waste Manag Assoc. 2013 Oct;63(10):1113-29
pubmed: 24282964
Chest. 2016 Feb;149(2):447-458
pubmed: 26111257
Environ Int. 2018 Jun;115:188-195
pubmed: 29574339
J Expo Sci Environ Epidemiol. 2013 May-Jun;23(3):322-7
pubmed: 23321859
Respir Med. 2011 Oct;105 Suppl 1:S31-7
pubmed: 22015083
Am J Respir Crit Care Med. 2014 Apr 15;189(8):983-93
pubmed: 24735032
Environ Sci Technol. 2009 Jul 1;43(13):5028-34
pubmed: 19673302
Environ Int. 2020 Oct;143:105974
pubmed: 32703584
Am J Med Sci. 2020 Jun;359(6):354-364
pubmed: 32498942
J Air Waste Manag Assoc. 2010 Nov;60(11):1327-34
pubmed: 21141426
Am J Physiol Lung Cell Mol Physiol. 2018 Apr 1;314(4):L642-L653
pubmed: 29351446
Lancet. 2002 Oct 19;360(9341):1233-42
pubmed: 12401268
Sci Total Environ. 2016 Jan 1;539:515-525
pubmed: 26383853
Clin Sci (Lond). 2016 Jul 1;130(13):1039-50
pubmed: 27215677
Environ Res. 2018 Aug;165:358-364
pubmed: 29783085
Am J Respir Crit Care Med. 2013 Apr 1;187(7):721-7
pubmed: 23392442
Occup Environ Med. 2011 Aug;68(8):562-9
pubmed: 20980452
Am J Respir Crit Care Med. 1999 Jan;159(1):179-87
pubmed: 9872837
Environ Sci Technol. 2014 Oct 21;48(20):12150-6
pubmed: 25252224
Am J Respir Crit Care Med. 2009 Jun 15;179(12):1115-20
pubmed: 19299499
J Thorac Dis. 2016 Jan;8(1):E69-74
pubmed: 26904255
Epidemiology. 2005 May;16(3):396-405
pubmed: 15824557
Environ Pollut. 2018 Dec;243(Pt B):978-987
pubmed: 30248605
Nutr Metab Cardiovasc Dis. 2005 Aug;15(4):316-28
pubmed: 16054557
Environ Health Perspect. 2011 Dec;119(12):1691-9
pubmed: 21810552
Antioxidants (Basel). 2021 Apr 29;10(5):
pubmed: 33946941
Environ Sci Technol. 2002 Dec 15;36(24):5305-14
pubmed: 12521154
Thorax. 2004 Jul;59(7):574-80
pubmed: 15223864